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Generative information retrieval, encompassing two major tasks of Generative Document Retrieval (GDR) and Grounded Answer Generation (GAR), has gained significant attention in the area of information retrieval and natural language…

Information Retrieval · Computer Science 2023-12-19 Xiaoxi Li , Yujia Zhou , Zhicheng Dou

Accurately forecasting extreme rainfall is notoriously difficult, but is also ever more crucial for society as climate change increases the frequency of such extremes. Global numerical weather prediction models often fail to capture…

Machine Learning · Statistics 2022-03-24 Ilan Price , Stephan Rasp

Enzymes are genetically encoded biocatalysts capable of accelerating chemical reactions. How can we automatically design functional enzymes? In this paper, we propose EnzyGen, an approach to learn a unified model to design enzymes across…

Machine Learning · Computer Science 2026-03-03 Zhenqiao Song , Yunlong Zhao , Wenxian Shi , Wengong Jin , Yang Yang , Lei Li

The harnessing of machine learning, especially deep generative models, has opened up promising avenues in the field of synthetic DNA sequence generation. Whilst Generative Adversarial Networks (GANs) have gained traction for this…

Machine Learning · Computer Science 2023-12-27 Zehui Li , Yuhao Ni , Tim August B. Huygelen , Akashaditya Das , Guoxuan Xia , Guy-Bart Stan , Yiren Zhao

Understanding how molecular changes caused by genetic variation drive disease risk is crucial for deciphering disease mechanisms. However, interpreting genome sequences is challenging because of the vast size of the human genome, and…

Two fundamental challenges face generative models in engineering applications: the acquisition of high-performing, diverse datasets, and the adherence to precise constraints in generated designs. We propose a novel approach combining…

Neural and Evolutionary Computing · Computer Science 2024-05-17 Adam Gaier , James Stoddart , Lorenzo Villaggi , Shyam Sudhakaran

Generative retrieval generates identifiers of relevant documents in an end-to-end manner using a sequence-to-sequence architecture for a given query. The relation between generative retrieval and other retrieval methods, especially those…

Information Retrieval · Computer Science 2024-04-02 Shiguang Wu , Wenda Wei , Mengqi Zhang , Zhumin Chen , Jun Ma , Zhaochun Ren , Maarten de Rijke , Pengjie Ren

Generating diverse sequences is important in many NLP applications such as question generation or summarization that exhibit semantically one-to-many relationships between source and the target sequences. We present a method to explicitly…

Computation and Language · Computer Science 2019-09-05 Jaemin Cho , Minjoon Seo , Hannaneh Hajishirzi

The genome sequence contains the blueprint for governing cellular processes. While the availability of genomes has vastly increased over the last decades, experimental annotation of the various functional, non-coding and regulatory elements…

Genomics · Quantitative Biology 2024-04-10 Frederikke Isa Marin , Felix Teufel , Marc Horlacher , Dennis Madsen , Dennis Pultz , Ole Winther , Wouter Boomsma

Medical imaging is an essential tool for diagnosing and treating diseases. However, lacking medical images can lead to inaccurate diagnoses and ineffective treatments. Generative models offer a promising solution for addressing medical…

Image and Video Processing · Electrical Eng. & Systems 2024-01-02 M. AbdulRazek , G. Khoriba , M. Belal

Recent research has shown that transformer networks can be used as differentiable search indexes by representing each document as a sequences of document ID tokens. These generative retrieval models cast the retrieval problem to a document…

Information Retrieval · Computer Science 2023-11-16 Hansi Zeng , Chen Luo , Bowen Jin , Sheikh Muhammad Sarwar , Tianxin Wei , Hamed Zamani

Planning with generative models has emerged as an effective decision-making paradigm across a wide range of domains, including reinforcement learning and autonomous navigation. While continuous replanning at each timestep might seem…

Robotics · Computer Science 2024-08-06 Pascal Jutras-Dubé , Ruqi Zhang , Aniket Bera

Generative models in molecular design tend to be richly parameterized, data-hungry neural models, as they must create complex structured objects as outputs. Estimating such models from data may be challenging due to the lack of sufficient…

Machine Learning · Computer Science 2021-08-17 Kevin Yang , Wengong Jin , Kyle Swanson , Regina Barzilay , Tommi Jaakkola

With the rapidly growing model complexity and data volume, training deep generative models (DGMs) for better performance has becoming an increasingly more important challenge. Previous research on this problem has mainly focused on…

Machine Learning · Computer Science 2021-12-08 Yufan Zhou , Chunyuan Li , Changyou Chen , Jinhui Xu

A deep generative model such as a GAN learns to model a rich set of semantic and physical rules about the target distribution, but up to now, it has been obscure how such rules are encoded in the network, or how a rule could be changed. In…

Computer Vision and Pattern Recognition · Computer Science 2020-07-31 David Bau , Steven Liu , Tongzhou Wang , Jun-Yan Zhu , Antonio Torralba

We present an architecture which lets us train deep, directed generative models with many layers of latent variables. We include deterministic paths between all latent variables and the generated output, and provide a richer set of…

Machine Learning · Computer Science 2016-12-15 Philip Bachman

Large language models (LLMs) are widely deployed in various downstream tasks, e.g., auto-completion, aided writing, or chat-based text generation. However, the considered output candidates of the underlying search algorithm are…

Human-Computer Interaction · Computer Science 2024-03-13 Thilo Spinner , Rebecca Kehlbeck , Rita Sevastjanova , Tobias Stähle , Daniel A. Keim , Oliver Deussen , Mennatallah El-Assady

The ability to generate complex and realistic human body animations at scale, while following specific artistic constraints, has been a fundamental goal for the game and animation industry for decades. Popular techniques include…

Computer Vision and Pattern Recognition · Computer Science 2020-05-29 Yi Zhou , Jingwan Lu , Connelly Barnes , Jimei Yang , Sitao Xiang , Hao li

Designing new chemical compounds with desired pharmaceutical properties is a challenging task and takes years of development and testing. Still, a majority of new drugs fail to prove efficient. Recent success of deep generative modeling…

Machine Learning · Computer Science 2021-09-15 Karina Zadorozhny , Lada Nuzhna

Long-range time series forecasting is usually based on one of two existing forecasting strategies: Direct Forecasting and Iterative Forecasting, where the former provides low bias, high variance forecasts and the latter leads to low…

Machine Learning · Computer Science 2022-12-14 Shiyu Liu , Rohan Ghosh , Mehul Motani