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The sequence of a protein is not only constrained by its physical and biochemical properties under current selection, but also by features of its past evolutionary history. Understanding the extent and the form that these evolutionary…

Populations and Evolution · Quantitative Biology 2015-06-22 Mathieu Hemery , Olivier Rivoire

In this paper we present a combinatorial optimisation view on the routing problem for connectionless packet networks by using the metaphor of a landscape. We examine the main properties of the routing landscapes as we define them and how…

Networking and Internet Architecture · Computer Science 2007-05-23 T. Michalareas , L. Sacks

We discuss the relevance of studying ecology within the framework of Complexity Science from a statistical mechanics approach. Ecology is concerned with understanding how systems level properties emerge out of the multitude of interactions…

Populations and Evolution · Quantitative Biology 2007-09-14 Henrik Jeldtoft Jensen , Elsa Arcaute

We investigate the selective forces that promote the emergence of modularity in nature. We demonstrate the spontaneous emergence of modularity in a population of individuals that evolve in a changing environment. We show that the level of…

Molecular Networks · Quantitative Biology 2009-11-13 Jiankui He , Jun Sun , Michael W. Deem

Modern software systems are often highly configurable to tailor varied requirements from diverse stakeholders. Understanding the mapping between configurations and the desired performance attributes plays a fundamental role in advancing the…

Software Engineering · Computer Science 2024-02-12 Mingyu Huang , Peili Mao , Ke Li

To celebrate Hans Frauenfelder's achievements, we examine energy(-like) "landscapes" for complex living systems. Energy landscapes summarize all possible dynamics of some physical systems. Energy(-like) landscapes can explain some…

Quantitative Methods · Quantitative Biology 2021-10-18 Lars Koopmans , Hyun Youk

This survey focuses on the most important aspects of the mathematical theory of population genetic models of selection and migration between discrete niches. Such models are most appropriate if the dispersal distance is short compared to…

Populations and Evolution · Quantitative Biology 2019-12-13 Reinhard Bürger

In these notes we discuss tools and concepts that emerge when studying high-dimensional random landscapes, i.e., random functions on high-dimensional spaces. As an illustrative example, we consider an inference problem in two forms:…

Disordered Systems and Neural Networks · Physics 2025-08-12 Valentina Ros

This chapter overviews a recently introduced network-based model of combinatorial landscapes: Local Optima Networks (LON). The model compresses the information given by the whole search space into a smaller mathematical object that is a…

Neural and Evolutionary Computing · Computer Science 2014-02-13 Gabriela Ochoa , Sébastien Verel , Fabio Daolio , Marco Tomassini

Understanding the origins of complexity is a fundamental challenge with implications for biological and technological systems. Network theory emerges as a powerful tool to model complex systems. Networks are an intuitive framework to…

Disordered Systems and Neural Networks · Physics 2024-10-22 Blai Vidiella , Salva Duran-Nebreda , Sergi Valverde

In complex systems, the interplay between nonlinear and stochastic dynamics, e.g., J. Monod's necessity and chance, gives rise to an evolutionary process in Darwinian sense, in terms of discrete jumps among attractors, with punctuated…

Adaptation and Self-Organizing Systems · Physics 2013-03-18 Hong Qian

Much of the current theory of adaptation is based on Gillespie's mutational landscape model (MLM), which assumes that the fitness values of genotypes linked by single mutational steps are independent random variables. On the other hand, a…

Populations and Evolution · Quantitative Biology 2014-11-11 Johannes Neidhart , Ivan G. Szendro , Joachim Krug

Molecular phenotypes are important links between genomic information and organismic functions, fitness, and evolution. Complex phenotypes, which are also called quantitative traits, often depend on multiple genomic loci. Their evolution…

Populations and Evolution · Quantitative Biology 2015-06-12 Armita Nourmohammad , Stephan Schiffels , Michael Laessig

Fitness landscapes have historically been a powerful tool for analyzing the search space explored by evolutionary algorithms. In particular, they facilitate understanding how easily reachable an optimal solution is from a given starting…

Neural and Evolutionary Computing · Computer Science 2024-08-23 Emily Dolson , Alexander Lalejini

We propose a method to investigate modular structure in networks based on fitted probabilistic model, where the connection probability between nodes is related to a set of introduced local attributes. The attributes, as parameters of the…

Physics and Society · Physics 2009-07-03 Xiaofeng Gong , C. -H. Lai

These lectures contain a brief description of evolutionary models inspired by the statistical mechanics of disordered systems. After an introduction describing the Darwinian paradigm of evolving populations, the deterministic quasispecies…

Disordered Systems and Neural Networks · Physics 2007-05-23 Luca Peliti

The landscape of low-energy effective field theories stemming from string theory is too vast for a systematic exploration. However, the meadows of the string landscape may be fertile ground for the application of machine learning…

High Energy Physics - Theory · Physics 2024-03-07 Stefano Lanza

Exploratory landscape analysis and fitness landscape analysis in general have been pivotal in facilitating problem understanding, algorithm design and endeavors such as automated algorithm selection and configuration. These techniques have…

Neural and Evolutionary Computing · Computer Science 2024-02-27 Raphael Patrick Prager , Heike Trautmann

Homologous recombination is an important operator in the evolution of biological organisms. However, there is still no clear, generally accepted understanding of why it exists and under what circumstances it is useful. In this paper we…

Populations and Evolution · Quantitative Biology 2013-08-12 Manuel Beltrán del Río , Christopher R. Stephens , David A. Rosenblueth

Interconnected ensembles of biological entities are perhaps some of the most complex systems that modern science has encountered so far. In particular, scientists have concentrated on understanding how the complexity of the interacting…

Pattern Formation and Solitons · Physics 2020-11-18 Bram A. Siebert , Cameron L. Hall , James P. Gleeson , Malbor Asllani
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