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Longitudinal brain analysis is essential for understanding healthy aging and identifying pathological deviations. Longitudinal registration of sequential brain MRI underpins such analyses. However, existing methods are limited by reliance…

Image and Video Processing · Electrical Eng. & Systems 2026-03-31 Bailiang Jian , Jiazhen Pan , Yitong Li , Fabian Bongratz , Ruochen Li , Daniel Rueckert , Benedikt Wiestler , Christian Wachinger

Understanding brain connectivity has become one of the most important issues in neuroscience. But connectivity data can reflect either the functional relationships of the brain activities or the anatomical properties between brain areas.…

Neurons and Cognition · Quantitative Biology 2015-04-13 Tiago Simas , Mario Chavez , Pablo Rodriguez , Albert Diaz-Guilera

We propose a method, based on persistent homology, to uncover topological properties of a priori unknown covariates of neuron activity. Our input data consist of spike train measurements of a set of neurons of interest, a candidate list of…

Neurons and Cognition · Quantitative Biology 2015-10-23 Gard Spreemann , Benjamin Dunn , Magnus Bakke Botnan , Nils A. Baas

We analyze functional magnetic resonance imaging (fMRI) data from the Human Connectome Project (HCP) to match brain activities during a range of cognitive tasks. Our findings demonstrate that even basic linear machine learning models can…

Neurons and Cognition · Quantitative Biology 2025-10-08 Valeriya Kirova , Dzerassa Kadieva , Daniil Vlasenko , Isak B. Blank , Fedor Ratnikov

Whole-brain computational modeling based on structural connectivity has shown great promise in successfully simulating fMRI BOLD signals with temporal co-activation patterns that are highly similar to empirical functional connectivity…

Neurons and Cognition · Quantitative Biology 2019-11-14 Neda Kaboodvand , Martijn P van den Heuvel , Peter Fransson

Human brain functional connectivity (FC) is often measured as the similarity of functional MRI responses across brain regions when a brain is either resting or performing a task. This paper aims to statistically analyze the dynamic nature…

Computer Vision and Pattern Recognition · Computer Science 2024-10-30 Mengyu Dai , Zhengwu Zhang , Anuj Srivastava

This works explores and illustrates recent results developed by the author in field of dynamical network analysis. The considered approach is blind, i.e., no a priori assumptions on the interconnected systems are available. Moreover, the…

Systems and Control · Computer Science 2015-03-19 Giacomo Innocenti

Temporal graph classification plays a critical role in applications such as cybersecurity, brain connectivity analysis, social dynamics, and traffic monitoring. Despite its significance, this problem remains underexplored compared to…

Machine Learning · Computer Science 2025-11-26 Md. Joshem Uddin , Soham Changani , Baris Coskunuzer

In this article, we introduce a Topological Data Analysis (TDA) pipeline for neural spike train data. Understanding how the brain transforms sensory information into perception and behavior requires analyzing coordinated neural population…

Methodology · Statistics 2025-12-10 Cagatay Ayhan , Audrey N. Nash , Roberto Vincis , Martin Bauer , Richard Bertram , Tom Needham

A large body of literature has shown the substantial inter-regional functional connectivity in the mammal brain. One important property remaining un-studied is the cross-time interareal connection. This paper serves to provide a tool to…

Neurons and Cognition · Quantitative Biology 2021-09-06 Ze Wang

Typical brain networks consist of many peripheral regions and a few highly central ones, i.e. hubs, playing key functional roles in cerebral inter-regional interactions. Studies have shown that networks, obtained from the analysis of…

Neurons and Cognition · Quantitative Biology 2016-07-19 Manlio De Domenico , Shuntaro Sasai , Alex Arenas

The integration of Fourier transform and deep learning opens new avenues for time series forecasting. We reconsider the Fourier transform from a basis functions perspective. Specifically, the real and imaginary parts of the frequency…

Machine Learning · Computer Science 2025-08-05 Runze Yang , Longbing Cao , Xin You , Kun Fang , Jianxun Li , Jie Yang

Understanding the dynamic reorganization of brain networks is critical for predicting cognitive decline, neurological progression, and individual variability in clinical outcomes. This work proposes a multimodal graph neural network…

Machine Learning · Computer Science 2026-02-11 Preksha Girish , Rachana Mysore , Kiran K. N. , Hiranmayee R. , Shipra Prashanth , Shrey Kumar

A wide range of data that appear in scientific experiments and simulations are multivariate or multifield in nature, consisting of multiple scalar fields. Topological feature search of such data aims to reveal important properties useful to…

Computational Geometry · Computer Science 2024-06-06 Tripti Agarwal , Amit Chattopadhyay , Vijay Natarajan

The various human brain tasks are performed at different locations and time scales. Yet, we discovered the existence of time-invariant (above an essential time scale) partitioning of the brain activity into personal state-specific frequency…

Medical Physics · Physics 2009-11-11 Itai Doron , Eyal Hulata , Itay Baruchi , Vernon L. Towle , Eshel Ben-Jacob

The analysis of the time-frequency content of a signal is a classical problem in signal processing, with a broad number of applications in real life. Many different approaches have been developed over the decades, which provide alternative…

Numerical Analysis · Mathematics 2022-06-02 Antonio Cicone , Wing Suet Li , Haomin Zhou

Objective: In recent years, the functional connectivity of the human brain has been studied with graph theoretical tools. One such approach is community detection which is fundamental for uncovering the localized networks. Existing methods…

Signal Processing · Electrical Eng. & Systems 2022-09-27 Abdullah Karaaslanli , Meiby Ortiz-Bouza , Tamanna T. K. Munia , Selin Aviyente

Characterization of real-world complex systems increasingly involves the study of their topological structure using graph theory. Among global network properties, small-world property, consisting in existence of relatively short paths…

Social and Information Networks · Computer Science 2017-02-28 Jaroslav Hlinka , David Hartman , Milan Paluš

Subtle alterations in brain network topology often evade detection by traditional statistical methods. To address this limitation, we introduce a Bayesian inference framework for topological comparison of brain networks that…

Methodology · Statistics 2025-11-06 Xukun Zhu , Michael W Lutz , Tananun Songdechakraiwut

Techniques from computational topology, in particular persistent homology, are becoming increasingly relevant for data analysis. Their stable metrics permit the use of many distance-based data analysis methods, such as multidimensional…

Algebraic Topology · Mathematics 2021-01-20 Bastian Rieck , Filip Sadlo , Heike Leitte