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Deep learning models excel in computer vision tasks but often fail to generalize to out-of-distribution (OOD) domains. Invariant Risk Minimization (IRM) aims to address OOD generalization by learning domain-invariant features. However, IRM…

Computer Vision and Pattern Recognition · Computer Science 2025-01-24 Yaoyao Zhu , Xiuding Cai , Yingkai Wang , Dong Miao , Zhongliang Fu , Xu Luo

Deep learning-based models in medical imaging often struggle to generalize effectively to new scans due to data heterogeneity arising from differences in hardware, acquisition parameters, population, and artifacts. This limitation presents…

Image and Video Processing · Electrical Eng. & Systems 2023-08-09 Sebastian Nørgaard Llambias , Mads Nielsen , Mostafa Mehdipour Ghazi

The domain shift between training and testing data presents a significant challenge for training generalizable deep learning models. As a consequence, the performance of models trained with the independent and identically distributed…

Computer Vision and Pattern Recognition · Computer Science 2023-09-19 Aleksandr Matsun , Dana O. Mohamed , Sharon Chokuwa , Muhammad Ridzuan , Mohammad Yaqub

Single-source domain generalization (SDG) in medical image segmentation is a challenging yet essential task as domain shifts are quite common among clinical image datasets. Previous attempts most conduct global-only/random augmentation.…

Computer Vision and Pattern Recognition · Computer Science 2022-11-29 Zixian Su , Kai Yao , Xi Yang , Qiufeng Wang , Jie Sun , Kaizhu Huang

Medical image segmentation plays a crucial role in clinical workflows, but domain shift often leads to performance degradation when models are applied to unseen clinical domains. This challenge arises due to variations in imaging…

Computer Vision and Pattern Recognition · Computer Science 2025-08-01 Yingkai Wang , Yaoyao Zhu , Xiuding Cai , Yuhao Xiao , Haotian Wu , Yu Yao

Recent advances in deep learning methods have come to define the state-of-the-art for many medical imaging applications, surpassing even human judgment in several tasks. Those models, however, when trained to reduce the empirical risk on a…

Computer Vision and Pattern Recognition · Computer Science 2019-01-14 Christian S. Perone , Pedro Ballester , Rodrigo C. Barros , Julien Cohen-Adad

Human medical data can be challenging to obtain due to data privacy concerns, difficulties conducting certain types of experiments, or prohibitive associated costs. In many settings, data from animal models or in-vitro cell lines are…

We propose a novel approach for domain generalisation (DG) leveraging risk distributions to characterise domains, thereby achieving domain invariance. In our findings, risk distributions effectively highlight differences between training…

Machine Learning · Computer Science 2023-10-31 Toan Nguyen , Kien Do , Bao Duong , Thin Nguyen

Inferring causal individual treatment effect (ITE) from observational data is a challenging problem whose difficulty is exacerbated by the presence of treatment assignment bias. In this work, we propose a new way to estimate the ITE using…

Machine Learning · Computer Science 2021-03-16 Abhin Shah , Kartik Ahuja , Karthikeyan Shanmugam , Dennis Wei , Kush Varshney , Amit Dhurandhar

Invariant risk minimization (IRM) has recently emerged as a promising alternative for domain generalization. Nevertheless, the loss function is difficult to optimize for nonlinear classifiers and the original optimization objective could…

Machine Learning · Computer Science 2022-03-22 Bo Li , Yifei Shen , Yezhen Wang , Wenzhen Zhu , Colorado J. Reed , Jun Zhang , Dongsheng Li , Kurt Keutzer , Han Zhao

Achieving health equity in Artificial Intelligence (AI) requires diagnostic models that maintain reliability across diverse populations. However, breast cancer screening systems frequently suffer from domain overfitting, degrading…

Computer Vision and Pattern Recognition · Computer Science 2026-01-27 Hung Q. Vo , Samira Zare , Son T. Ly , Lin Wang , Chika F. Ezeana , Xiaohui Yu , Kelvin K. Wong , Stephen T. C. Wong , Hien V. Nguyen

Medical image segmentation models are often trained on curated datasets, leading to performance degradation when deployed in real-world clinical settings due to mismatches between training and test distributions. While data augmentation…

Computer Vision and Pattern Recognition · Computer Science 2025-05-16 Puru Vaish , Felix Meister , Tobias Heimann , Christoph Brune , Jelmer M. Wolterink

Despite the huge effort in developing novel regularizers for Domain Generalization (DG), adding simple data augmentation to the vanilla ERM which is a practical implementation of the Vicinal Risk Minimization principle (VRM)…

Machine Learning · Computer Science 2023-12-12 Sobhan Hemati , Mahdi Beitollahi , Amir Hossein Estiri , Bassel Al Omari , Xi Chen , Guojun Zhang

Invariant risk minimization (IRM) aims to enable out-of-distribution (OOD) generalization in deep learning by learning invariant representations. As IRM poses an inherently challenging bi-level optimization problem, most existing approaches…

Machine Learning · Computer Science 2025-05-26 Kotaro Yoshida , Konstantinos Slavakis

We tackle the challenging problem of single-source domain generalization (DG) for medical image segmentation, where we train a network on one domain (e.g., CT) and directly apply it to a different domain (e.g., MR) without adapting the…

Computer Vision and Pattern Recognition · Computer Science 2026-04-29 Franz Thaler , Martin Urschler , Mateusz Kozinski , Matthias AF Gsell , Gernot Plank , Darko Stern

Data augmentation has proved extremely useful by increasing training data variance to alleviate overfitting and improve deep neural networks' generalization performance. In medical image analysis, a well-designed augmentation policy usually…

Computer Vision and Pattern Recognition · Computer Science 2021-03-31 Yunhe Gao , Zhiqiang Tang , Mu Zhou , Dimitris Metaxas

Emerging diseases present challenges in symptom recognition and timely clinical intervention due to limited available information. An effective prognostic model could assist physicians in making accurate diagnoses and designing personalized…

Machine Learning · Computer Science 2025-02-12 Zhongji Zhang , Yuhang Wang , Yinghao Zhu , Xinyu Ma , Yasha Wang , Junyi Gao , Liantao Ma , Wen Tang , Xiaoyun Zhang , Ling Wang

For medical image analysis, segmentation models trained on one or several domains lack generalization ability to unseen domains due to discrepancies between different data acquisition policies. We argue that the degeneration in segmentation…

Computer Vision and Pattern Recognition · Computer Science 2022-08-09 Ziqi Zhou , Lei Qi , Yinghuan Shi

Diabetic Retinopathy (DR) constitutes 5% of global blindness cases. While numerous deep learning approaches have sought to enhance traditional DR grading methods, they often falter when confronted with new out-of-distribution data thereby…

Image and Video Processing · Electrical Eng. & Systems 2024-11-06 Sharon Chokuwa , Muhammad Haris Khan

Empirical Risk Minimization (ERM) based machine learning algorithms have suffered from weak generalization performance on data obtained from out-of-distribution (OOD). To address this problem, Invariant Risk Minimization (IRM) objective was…

Machine Learning · Computer Science 2021-03-25 Jun-Hyun Bae , Inchul Choi , Minho Lee
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