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The identification of abnormal electrographic activity is important in a wide range of neurological disorders, including epilepsy for localising epileptogenic tissue. However, this identification may be challenging during non-seizure…

Normative modelling is an increasingly common statistical technique in neuroimaging that estimates population-level benchmarks in brain structure. It enables the quantification of individual deviations from expected distributions whilst…

Neurons and Cognition · Quantitative Biology 2025-10-21 Nida Alyas , Jonathan Horsley , Bethany Little , Peter N. Taylor , Yujiang Wang , Karoline Leiberg

A normative electrographic activity map could be a powerful resource to understand normal brain function and identify abnormal activity. Here, we present a normative brain map using scalp EEG in terms of relative band power. In this…

Neurons and Cognition · Quantitative Biology 2023-04-07 Vytene Janiukstyte , Thomas W Owen , Umair J Chaudhary , Beate Diehl , Louis Lemieux , John S Duncan , Jane de Tisi , Yujiang Wang , Peter N Taylor

Background: Understanding healthy human brain function is crucial to identify and map pathological tissue within it. Whilst previous studies have mapped intracranial EEG (icEEG) from non-epileptogenic brain regions, these maps do not…

Identifying abnormal electroencephalographic activity is crucial in diagnosis and treatment of epilepsy. Recent studies showed that decomposing brain activity into periodic (oscillatory) and aperiodic (trend across all frequencies)…

Neurons and Cognition · Quantitative Biology 2023-10-11 Csaba Kozma , Gabrielle Schroeder , Tom Owen , Jane de Tisi , Andrew W. McEvoy , Anna Miserocchi , John Duncan , Yujiang Wang , Peter N. Taylor

High-resolution neural datasets enable foundation models for the next generation of brain-computer interfaces and neurological treatments. The community requires rigorous benchmarks to discriminate between competing modeling approaches, yet…

Robust decoding and classification of brain patterns measured with electroencephalography (EEG) remains a major challenge for real-world (i.e. outside scientific lab and medical facilities) brain-computer interface (BCI) applications due to…

Neurons and Cognition · Quantitative Biology 2025-12-03 Paul Barbaste , Olivier Oullier , Xavier Vasques

Epilepsy affects over 50 million people worldwide, and one-third of patients suffer drug-resistant seizures where surgery offers the best chance of seizure freedom. Accurate localization of the epileptogenic zone (EZ) relies on intracranial…

Magnetoencephalographic (MEG) recordings from a large normative cohort (n = 619) were processed to extract measures of regional neuroelectric activity. The overall objective of the effort was to use these measures to identify normative…

Neurons and Cognition · Quantitative Biology 2018-11-20 Don Krieger , Paul Shepard , David O. Okonkwo

Neurological disorders pose major global health challenges, driving advances in brain signal analysis. Scalp electroencephalography (EEG) and intracranial EEG (iEEG) are widely used for diagnosis and monitoring. However, dataset…

Neurons and Cognition · Quantitative Biology 2025-10-24 Jiahe Li , Xin Chen , Fanqi Shen , Junru Chen , Yuxin Liu , Daoze Zhang , Zhizhang Yuan , Fang Zhao , Meng Li , Yang Yang

EEG recordings contain rich information about neural activity but are subject to artifacts, noise, and superficial differences due to sensors, amplifiers, and filtering. Independent component analysis and automatic labeling of independent…

Machine Learning · Computer Science 2025-12-05 Austin Meek , Carlos H. Mendoza-Cardenas , Austin J. Brockmeier

Electroencephalography (EEG) is essential for the diagnosis of epilepsy, but it requires expertise and experience to identify abnormalities. It is thus crucial to develop automated models for the detection of abnormalities in EEGs related…

Signal Processing · Electrical Eng. & Systems 2021-11-23 Taku Shoji , Noboru Yoshida , Toshihisa Tanaka

Intracranial EEG (iEEG) is the gold standard technique for epileptogenic zone (EZ) localisation, but requires a hypothesis of which tissue is epileptogenic, guided by qualitative analysis of seizure semiology and other imaging modalities…

Background: Topological data analysis (TDA) has exploded as a tool for analyzing and making sense of high dimensional datasets across a variety of fields. Mapper is a tool from TDA that captures low-dimensional structure from…

General Topology · Mathematics 2025-12-04 Brittany Story , Zhibin Zhou , Ramesh Srinivasan , Scott Kerick , David Boothe , Piotr J. Franaszczuk

Objective: Identifying abnormalities in interictal intracranial EEG, by comparing patient data to a normative map, has shown promise for the localisation of epileptogenic tissue and prediction of outcome. The approach typically uses short…

This paper presents a novel graph convolutional neural network (GCNN)-based approach for improving the diagnosis of neurological diseases using scalp-electroencephalograms (EEGs). Although EEG is one of the main tests used for…

Signal Processing · Electrical Eng. & Systems 2020-11-25 Neeraj Wagh , Yogatheesan Varatharajah

Insomnia affects a vast population of the world and can have a wide range of causes. Existing treatments for insomnia have been linked with many side effects like headaches, dizziness, etc. As such, there is a clear need for improved…

Signal Processing · Electrical Eng. & Systems 2025-07-22 Kevin Monteiro , Sam Nallaperuma-Herzberg , Martina Mason , Steve Niederer

Brain-related disorders such as epilepsy can be diagnosed by analyzing electroencephalograms (EEG). However, manual analysis of EEG data requires highly trained clinicians, and is a procedure that is known to have relatively low inter-rater…

Signal Processing · Electrical Eng. & Systems 2018-05-21 Subhrajit Roy , Isabell Kiral-Kornek , Stefan Harrer

Chronic neck pain is a leading cause of disability worldwide, and current treatment selection remains largely trial and error. We present a machine learning framework that uses electroencephalography to predict treatment efficacy in…

Quantitative Methods · Quantitative Biology 2026-05-19 Xiru Wang , Aiden Li , Hongzhao Tan , Stevie Foglia , Aimee Nelson , Zhen Gao

Normative models of brain structure estimate the effects of covariates such as age and sex using large samples of healthy controls. These models can then be applied to e.g. smaller clinical cohorts to distinguish disease effects from other…

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