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Alzheimer's Disease (AD) is the world's leading neurodegenerative disease, which often results in communication difficulties. Analysing speech can serve as a diagnostic tool for identifying the condition. The recent ADReSS challenge…

Computation and Language · Computer Science 2024-07-24 Lucía Gómez-Zaragozá , Simone Wills , Cristian Tejedor-Garcia , Javier Marín-Morales , Mariano Alcañiz , Helmer Strik

With the global population aging rapidly, Alzheimer's disease (AD) is particularly prominent in older adults, which has an insidious onset and leads to a gradual, irreversible deterioration in cognitive domains (memory, communication,…

Audio and Speech Processing · Electrical Eng. & Systems 2023-03-15 Jinchao Li , Kaitao Song , Junan Li , Bo Zheng , Dongsheng Li , Xixin Wu , Xunying Liu , Helen Meng

Alzheimer's Disease is a devastating neurological disorder that is increasingly affecting the elderly population. Early and accurate detection of Alzheimer's is crucial for providing effective treatment and support for patients and their…

Image and Video Processing · Electrical Eng. & Systems 2023-04-27 Krishna Mahapatra , Selvakumar R

Depression is a common mental disorder worldwide which causes a range of serious outcomes. The diagnosis of depression relies on patient-reported scales and psychiatrist interview which may lead to subjective bias. In recent years, more and…

Audio and Speech Processing · Electrical Eng. & Systems 2020-03-02 Zhenyu Liu , Dongyu Wang , Lan Zhang , Bin Hu

Alzheimer's disease is one of the most incisive illnesses among the neurodegenerative ones, and it causes a progressive decline in cognitive abilities that, in the worst cases, becomes severe enough to interfere with daily life. Currently,…

Computer Vision and Pattern Recognition · Computer Science 2024-05-28 Tiziana D'Alessandro , Cristina Carmona-Duarte , Claudio De Stefano , Moises Diaz , Miguel A. Ferrer , Francesco Fontanella

Detection of subtle deficits in everyday functioning due to cognitive impairment is important for early detection of neurodegenerative diseases, particularly Alzheimer's disease. However, current standards for assessment of everyday…

Audio and Speech Processing · Electrical Eng. & Systems 2023-09-13 Yasunori Yamada , Kaoru Shinkawa , Masatomo Kobayashi , Miyuki Nemoto , Miho Ota , Kiyotaka Nemoto , Tetsuaki Arai

This study investigates explainable machine learning algorithms for identifying depression from speech. Grounded in evidence from speech production that depression affects motor control and vowel generation, pre-trained vowel-based…

Machine Learning · Computer Science 2024-10-25 Kexin Feng , Theodora Chaspari

We describe a new method to automatically discriminate between patients with Alzheimer's disease (AD) or mild cognitive impairment (MCI) and elderly controls, based on multidimensional classification of hippocampal shape features. This…

This study addresses the TAUKADIAL challenge, focusing on the classification of speech from people with Mild Cognitive Impairment (MCI) and neurotypical controls. We conducted three experiments comparing five machine-learning methods:…

Neurons and Cognition · Quantitative Biology 2024-08-30 Cong Zhang , Wenxing Guo , Hongsheng Dai

Early diagnosis of Alzheimer's Disease (AD) faces multiple data-related challenges, including high variability in patient data, limited access to specialized diagnostic tests, and overreliance on single-type indicators. These challenges are…

Quantitative Methods · Quantitative Biology 2025-03-05 Yizong Xing , Dhita Putri Pratama , Yuke Wang , Yufan Zhang , Brian E. Chapman

Alzheimer's Disease (AD) detection employs machine learning classification models to distinguish between individuals with AD and those without. Different from conventional classification tasks, we identify within-class variation as a…

Audio and Speech Processing · Electrical Eng. & Systems 2025-09-29 Jiawen Kang , Dongrui Han , Lingwei Meng , Jingyan Zhou , Jinchao Li , Xixin Wu , Helen Meng

Neurodegenerative diseases are frequently associated with structural changes in the brain. Magnetic Resonance Imaging (MRI) scans can show these variations and therefore be used as a supportive feature for a number of neurodegenerative…

Early diagnosis of Alzheimer's disease (AD) is crucial in facilitating preventive care and to delay further progression. Speech based automatic AD screening systems provide a non-intrusive and more scalable alternative to other clinical…

Computation and Language · Computer Science 2023-04-03 Yi Wang , Jiajun Deng , Tianzi Wang , Bo Zheng , Shoukang Hu , Xunying Liu , Helen Meng

Depression commonly co-occurs with neurodegenerative disorders like Multiple Sclerosis (MS), yet the potential of speech-based Artificial Intelligence for detecting depression in such contexts remains unexplored. This study examines the…

Computation and Language · Computer Science 2025-08-26 Monica Gonzalez-Machorro , Uwe Reichel , Pascal Hecker , Helly Hammer , Hesam Sagha , Florian Eyben , Robert Hoepner , Björn W. Schuller

Speech datasets for identifying Alzheimer's disease (AD) are generally restricted to participants performing a single task, e.g. describing an image shown to them. As a result, models trained on linguistic features derived from such…

Machine Learning · Computer Science 2018-11-30 Aparna Balagopalan , Jekaterina Novikova , Frank Rudzicz , Marzyeh Ghassemi

Early detection of dementia is crucial to devise effective interventions. Comprehensive cognitive tests, while being the most accurate means of diagnosis, are long and tedious, thus limiting their applicability to a large population,…

Computer Vision and Pattern Recognition · Computer Science 2025-05-30 Anusha A. S. , Uma Ranjan , Medha Sharma , Siddharth Dutt

The ability to accurately detect onset of dementia is important in the treatment of the disease. Clinically, the diagnosis of Alzheimer Disease (AD) and Mild Cognitive Impairment (MCI) patients are based on an integrated assessment of…

Signal Processing · Electrical Eng. & Systems 2022-11-18 Wan-Ting Hsieh , Jeremy Lefort-Besnard , Hao-Chun Yang , Li-Wei Kuo , Chi-Chun Lee

The differential diagnosis of neurodegenerative diseases, characterized by overlapping symptoms, may be challenging. Brain imaging coupled with artificial intelligence has been previously proposed for diagnostic support, but most of these…

Image and Video Processing · Electrical Eng. & Systems 2025-02-21 Pierrick Coupé , Boris Mansencal , José V. Manjón , Patrice Péran , Wassilios G. Meissner , Thomas Tourdias , Vincent Planche

Behavioral and Psychological Symptoms of Dementia (BPSD) impact dementia care substantially, affecting both patients and caregivers. Effective management and early detection of BPSD are crucial to reduce the stress and burden on caregivers…

Signal Processing · Electrical Eng. & Systems 2024-10-25 Benny Wei-Yun Hsu , Yu-Ming Chen , Yuan-Han Yang , Vincent S. Tseng

We present a probabilistic programmed deep kernel learning approach to personalized, predictive modeling of neurodegenerative diseases. Our analysis considers a spectrum of neural and symbolic machine learning approaches, which we assess…

Machine Learning · Computer Science 2021-01-13 Alexander Lavin