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Quantum simulation is making a significant impact on scientific research. The prevailing tendency of the field is to build quantum simulators that get closer to real-world systems of interest, in particular electronic materials. However,…

We consider the problem of obtaining locally D-optimal designs for factorial experiments with qualitative factors at two levels each with binary response. Our focus is primarily on the 2^2 experiment. In this paper, we derive analytic…

Methodology · Statistics 2015-03-13 Abhyuday Mandal , Jie Yang , Dibyen Majumdar

Qualitative modelling is a technique integrating the fields of theoretical computer science, artificial intelligence and the physical and biological sciences. The aim is to be able to model the behaviour of systems without estimating…

Computational Engineering, Finance, and Science · Computer Science 2012-09-19 Thomas W. Kelsey , Lars Kotthoff , Christoffer A. Jefferson , Stephen A. Linton , Ian Miguel , Peter Nightingale , Ian P. Gent

A combinatorial intervention, consisting of multiple treatments applied to a single unit with potentially interactive effects, has substantial applications in fields such as biomedicine, engineering, and beyond. Given $p$ possible…

Machine Learning · Computer Science 2025-06-05 Divya Shyamal , Jiaqi Zhang , Caroline Uhler

In experimental design, we are given $n$ vectors in $d$ dimensions, and our goal is to select $k\ll n$ of them to perform expensive measurements, e.g., to obtain labels/responses, for a linear regression task. Many statistical criteria have…

Machine Learning · Computer Science 2019-06-11 Michał Dereziński , Feynman Liang , Michael W. Mahoney

Over the past decade we have seen an explosion of demonstrations of quantum coherence in atomic, optical, and condensed matter systems. These developments have placed a new emphasis on the production of robust and optimal quantum control…

Quantum Physics · Physics 2015-05-20 M. J. Biercuk , A. C. Doherty , H. Uys

Machine learning methods are increasingly employed to address challenges faced by biologists. One area that will greatly benefit from this cross-pollination is the problem of biological sequence design, which has massive potential for…

Quantitative Methods · Quantitative Biology 2020-10-26 Sam Sinai , Eric D Kelsic

The optimization of composition and processing to obtain materials that exhibit desirable characteristics has historically relied on a combination of scientist intuition, trial and error, and luck. We propose a methodology that can…

Machine Learning · Statistics 2017-07-20 Julia Ling , Max Hutchinson , Erin Antono , Sean Paradiso , Bryce Meredig

Uncertainty quantification (UQ) has received much attention in the literature in the past decade. In this context, Sparse Polynomial chaos expansions (PCE) have been shown to be among the most promising methods because of their ability to…

Methodology · Statistics 2017-03-17 N. Fajraoui , S. Marelli , B. Sudret

Experimental design has emerged as a powerful approach for improving the sample efficiency of A/B testing, yet existing designs rely critically on correctly specified models. We study robust sequential experimental design under model…

Machine Learning · Statistics 2026-05-14 Qianglin Wen , Xiangkun Wu , Chengchun Shi , Ting Li , Niansheng Tang , Yingying Zhang , Hongtu Zhu

This paper introduces a novel quantum embedding search algorithm (QES, pronounced as "quest"), enabling search for optimal quantum embedding design for a specific dataset of interest. First, we establish the connection between the…

Quantum Physics · Physics 2022-04-20 Nam Nguyen , Kwang-Chen Chen

Physical design refers to mathematical optimization of a desired objective (e.g. strong light--matter interactions, or complete quantum state transfer) subject to the governing dynamical equations, such as Maxwell's or Schrodinger's…

Optics · Physics 2023-04-03 Shai Gertler , Zeyu Kuang , Colin Christie , Owen D. Miller

Design of experiments is a fundamental topic in applied statistics with a long history. Yet its application is often limited by the complexity and costliness of constructing experimental designs, which involve searching a high-dimensional…

Methodology · Statistics 2022-03-29 Matthew T. Pratola , C. Devon Lin , Peter F. Craigmile

Two-level designs are widely used for screening experiments where the goal is to identify a few active factors which have major effects. Orthogonal two-level designs in which all factors are level-balance and each of the four level…

Methodology · Statistics 2025-04-08 Pi-Wen Tsai , Steven G. Gilmour

The efficiency of an experimental design is ultimately measured in terms of time and resources needed for the experiment. Optimal sequential (multi-stage) design is studied in the situation where each stage involves a fixed cost. The…

Statistics Theory · Mathematics 2012-11-08 Juha Karvanen

The availability of working quantum computers has led to several proposals and claims of quantum advantage. In 2023, this has included claims that quantum computers can successfully factor large integers, by optimizing the search for nearby…

Quantum Physics · Physics 2023-08-16 Willie Aboumrad , Dominic Widdows , Ananth Kaushik

We propose a methodology to design optimal pulses for achieving quantum optimal control on molecular systems. Our approach constrains pulse shapes to linear combinations of a fixed number of experimentally relevant pulse functions. Quantum…

Quantum Physics · Physics 2015-10-28 Ruben D. Guerrero , Carlos A. Arango , Andres Reyes

Computer experiments refer to the study of real systems using complex simulation models. They have been widely used as alternatives to physical experiments. Design and analysis of computer experiments have attracted great attention in past…

Methodology · Statistics 2025-04-29 Anita Shahrokhian , Xinwei Deng , C. Devon Lin

Sequential design is a highly active field of research in active learning which provides a general framework for designing computer experiments with limited computational budgets. It aims to create efficient surrogate models to replace…

Methodology · Statistics 2025-01-03 Paul Lartaud , Philippe Humbert , Josselin Garnier

This paper traces the strong relations between experimental design and control, such as the use of optimal inputs to obtain precise parameter estimation in dynamical systems and the introduction of suitably designed perturbations in…

Optimization and Control · Mathematics 2008-03-03 Luc Pronzato