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Multiphase contrast-enhanced computed tomography (CECT) scan is clinically significant to demonstrate the anatomy at different phases. In practice, such a multiphase CECT scan inherently takes longer time and deposits much more radiation…

Image and Video Processing · Electrical Eng. & Systems 2023-06-14 Rongjun Ge , Yuting He , Cong Xia , Yang Chen , Daoqiang Zhang , Ge Wang

X-ray computed tomography (CT) is widely used for medical diagnosis and treatment planning; however, concerns about ionizing radiation exposure drive efforts to optimize image quality at lower doses. This study introduces Poisson Flow…

Image and Video Processing · Electrical Eng. & Systems 2025-02-25 Dennis Hein , Grant Stevens , Adam Wang , Ge Wang

The Poisson Flow Consistency Model (PFCM) is a consistency-style model based on the robust Poisson Flow Generative Model++ (PFGM++) which has achieved success in unconditional image generation and CT image denoising. Yet the PFCM can only…

Computer Vision and Pattern Recognition · Computer Science 2025-10-28 Anthony Zhang , Mahmut Gokmen , Dennis Hein , Rongjun Ge , Wenjun Xia , Ge Wang , Jin Chen

Diffusion and Poisson flow models have shown impressive performance in a wide range of generative tasks, including low-dose CT image denoising. However, one limitation in general, and for clinical applications in particular, is slow…

Image and Video Processing · Electrical Eng. & Systems 2023-12-20 Dennis Hein , Staffan Holmin , Timothy Szczykutowicz , Jonathan S Maltz , Mats Danielsson , Ge Wang , Mats Persson

In computed tomography (CT), reducing the number of projection views is an effective strategy to lower radiation exposure and/or improve temporal resolution. However, this often results in severe aliasing artifacts and loss of structural…

Image and Video Processing · Electrical Eng. & Systems 2025-11-19 Changsheng Fang , Yongtong Liu , Bahareh Morovati , Shuo Han , Li Zhou , Hengyong Yu

Deep learning has proven to be important for CT image denoising. However, such models are usually trained under supervision, requiring paired data that may be difficult to obtain in practice. Diffusion models offer unsupervised means of…

Computed tomography (CT) is a major medical imaging modality. Clinical CT scenarios, such as low-dose screening, sparse-view scanning, and metal implants, often lead to severe noise and artifacts in reconstructed images, requiring improved…

Image and Video Processing · Electrical Eng. & Systems 2025-06-04 Wenjun Xia , Chuang Niu , Ge Wang

Sparse-view computed tomography (CT) is a practical solution to reduce radiation dose, but the resulting ill-posed inverse problem poses significant challenges for accurate image reconstruction. Although deep learning and diffusion-based…

Image and Video Processing · Electrical Eng. & Systems 2025-06-10 Changsheng Fang , Yongtong Liu , Bahareh Morovati , Shuo Han , Yu Shi , Li Zhou , Shuyi Fan , Hengyong Yu

Objective: Positron Emission Tomography (PET) has been a commonly used imaging modality in broad clinical applications. One of the most important tradeoffs in PET imaging is between image quality and radiation dose: high image quality comes…

Image and Video Processing · Electrical Eng. & Systems 2024-04-18 Shaoyan Pan , Elham Abouei , Junbo Peng , Joshua Qian , Jacob F Wynne , Tonghe Wang , Chih-Wei Chang , Justin Roper , Jonathon A Nye , Hui Mao , Xiaofeng Yang

We propose a new "Poisson flow" generative model (PFGM) that maps a uniform distribution on a high-dimensional hemisphere into any data distribution. We interpret the data points as electrical charges on the $z=0$ hyperplane in a space…

Machine Learning · Computer Science 2022-10-21 Yilun Xu , Ziming Liu , Max Tegmark , Tommi Jaakkola

Positron emission tomography (PET) is an advanced medical imaging technique that plays a crucial role in non-invasive clinical diagnosis. However, while reducing radiation exposure through low-dose PET scans is beneficial for patient…

Computer Vision and Pattern Recognition · Computer Science 2024-07-02 Bin Huang , Xubiao Liu , Lei Fang , Qiegen Liu , Bingxuan Li

Positron Emission Tomography and Magnetic Resonance Imaging (PET-MRI) systems can obtain functional and anatomical scans. PET suffers from a low signal-to-noise ratio. Meanwhile, the k-space data acquisition process in MRI is…

Image and Video Processing · Electrical Eng. & Systems 2024-07-12 Taofeng Xie , Zhuo-Xu Cui , Chen Luo , Huayu Wang , Congcong Liu , Yuanzhi Zhang , Xuemei Wang , Yanjie Zhu , Guoqing Chen , Dong Liang , Qiyu Jin , Yihang Zhou , Haifeng Wang

Purpose: Prenatal ultrasound is a key tool in evaluating fetal structural development and detecting abnormalities, contributing to reduced perinatal complications and improved neonatal survival. Accurate identification of standard fetal…

Computer Vision and Pattern Recognition · Computer Science 2025-08-14 Shengjun Zhu , Siyu Liu , Runqing Xiong , Liping Zheng , Duo Ma , Rongshang Chen , Jiaxin Cai

To obtain high-quality positron emission tomography (PET) scans while reducing radiation exposure to the human body, various approaches have been proposed to reconstruct standard-dose PET (SPET) images from low-dose PET (LPET) images. One…

Image and Video Processing · Electrical Eng. & Systems 2023-08-22 Zeyu Han , Yuhan Wang , Luping Zhou , Peng Wang , Binyu Yan , Jiliu Zhou , Yan Wang , Dinggang Shen

Positron emission tomography (PET) is widely used to assess metabolic activity, but its application is limited by the availability of radiotracers. 18F-labeled fluorodeoxyglucose (18F-FDG) is the most commonly used tracer but shows limited…

Image and Video Processing · Electrical Eng. & Systems 2025-06-24 Fang Chen , Weifeng Zhang , Xingyu Ai , BingXuan Li , An Li , Qiegen Liu

Positron Emission Tomography (PET) is an important clinical imaging tool but inevitably introduces radiation hazards to patients and healthcare providers. Reducing the tracer injection dose and eliminating the CT acquisition for attenuation…

Computer Vision and Pattern Recognition · Computer Science 2024-06-18 Tianqi Chen , Jun Hou , Yinchi Zhou , Huidong Xie , Xiongchao Chen , Qiong Liu , Xueqi Guo , Menghua Xia , James S. Duncan , Chi Liu , Bo Zhou

We introduce a new family of physics-inspired generative models termed PFGM++ that unifies diffusion models and Poisson Flow Generative Models (PFGM). These models realize generative trajectories for $N$ dimensional data by embedding paths…

Machine Learning · Computer Science 2023-02-13 Yilun Xu , Ziming Liu , Yonglong Tian , Shangyuan Tong , Max Tegmark , Tommi Jaakkola

Daily or weekly cone-beam computed tomography (CBCT) is employed in image-guided radiotherapy (IGRT) for precise patient alignment. However, its clinical utility in quantitative tasks is hindered by severe artifacts and inaccurate Hounsfeld…

Medical Physics · Physics 2026-03-09 Junbo Peng , Huiqiao Xie , Tonghe Wang , Xiangyang Tang , Xiaofeng Yang

Cone-beam computed tomography (CBCT) is widely used in image-guided radiotherapy. Reconstructing CBCTs from limited-angle acquisitions (LA-CBCT) is highly desired for improved imaging efficiency, dose reduction, and better mechanical…

Medical Physics · Physics 2024-04-10 Jiacheng Xie , Hua-Chieh Shao , Yunxiang Li , You Zhang

Diffusion models have demonstrated significant potential in producing high-quality images in medical image translation to aid disease diagnosis, localization, and treatment. Nevertheless, current diffusion models have limited success in…

Image and Video Processing · Electrical Eng. & Systems 2024-11-26 Yunxiang Li , Hua-Chieh Shao , Xiaoxue Qian , You Zhang
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