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This paper concerns a distributed optimal control problem for a tumor growth model of Cahn-Hilliard type including chemotaxis with possibly singular potentials, where the control and state variables are nonlinearly coupled. First, we…

Optimization and Control · Mathematics 2023-06-06 Pierluigi Colli , Andrea Signori , Jürgen Sprekels

In this paper, we study a distributed optimal control problem for a diffuse interface model for tumor growth. The model consists of a Cahn-Hilliard type equation for the phase field variable coupled to a reaction diffusion equation for the…

Optimization and Control · Mathematics 2021-10-12 Matthias Ebenbeck , Patrik Knopf

A distributed optimal control problem for a phase field system which physical context is that of tumor growth is discussed. The system we are going to take into account consists of a Cahn-Hilliard equation for the phase variable (relative…

Analysis of PDEs · Mathematics 2021-01-20 Andrea Signori

This work investigates the well-posedness and optimal control of a sixth-order Cahn-Hilliard equation, a higher-order variant of the celebrated and well-established Cahn-Hilliard equation. The equation is endowed with a source term, where…

Analysis of PDEs · Mathematics 2024-05-01 Pierluigi Colli , Gianni Gilardi , Andrea Signori , Jürgen Sprekels

We consider the inverse problem of identifying parameters in a variant of the diffuse interface model for tumour growth model proposed by Garcke, Lam, Sitka and Styles (Math. Models Methods Appl. Sci. 2016). The model contains three…

Optimization and Control · Mathematics 2017-07-24 Christian Kahle , Kei Fong Lam

In this paper, we study an optimal control problem for a two-dimensional Cahn-Hilliard-Darcy system with mass sources that arises in the modeling of tumor growth. The aim is to monitor the tumor fraction in a finite time interval in such a…

Analysis of PDEs · Mathematics 2023-07-28 Juergen Sprekels , Hao Wu

We study a Cahn-Hilliard-Darcy system with mass sources, which can be considered as a basic, though simplified, diffuse interface model for the evolution of tumor growth. This system is equipped with an impermeability condition for the…

Optimization and Control · Mathematics 2024-08-20 Marco Abatangelo , Cecilia Cavaterra , Maurizio Grasselli , Hao Wu

In this paper we study the optimal control of an initial-boundary value problem for the classical nonviscous Cahn-Hilliard system with zero Neumann boundary conditions. Phase field systems of this type govern the evolution of diffusive…

Optimization and Control · Mathematics 2024-06-12 Pierluigi Colli , Jürgen Sprekels

In this paper we study nonlocal-to-local asymptotics for a tumor-growth model coupling a viscous Cahn-Hilliard equation describing the tumor proportion with a reaction-diffusion equation for the nutrient phase parameter. First, we prove…

Analysis of PDEs · Mathematics 2023-11-20 Elisa Davoli , Elisabetta Rocca , Luca Scarpa , Lara Trussardi

This paper is concerned with a boundary control problem for the Cahn--Hilliard equation coupled with dynamic boundary conditions. In order to handle the control problem, we restrict our analysis to the case of regular potentials defined on…

Analysis of PDEs · Mathematics 2021-01-20 Pierluigi Colli , Andrea Signori

We consider an optimal control problem for a diffuse interface model of tumor growth. The state equations couples a Cahn-Hilliard equation and a reaction-diffusion equation, which models the growth of a tumor in the presence of a nutrient…

Optimization and Control · Mathematics 2016-08-02 Harald Garcke , Kei-Fong Lam , Elisabetta Rocca

In this work, we investigate optimal control of a Brinkman equation couple with sixth-order Cahn-Hilliard equation. The Cahn-Hilliard equation is endowed with a source term accounting for mass exchange and the velocity equation contains a…

Optimization and Control · Mathematics 2025-12-09 Manika Bag

We consider a particular phase field system which physical context is that of tumor growth dynamics. The model we deal with consists of a Cahn-Hilliard type equation governing the evolution of the phase variable which takes into account the…

Analysis of PDEs · Mathematics 2019-08-30 Andrea Signori

This paper is intended to tackle the control problem associated with an extended phase field system of Cahn-Hilliard type that is related to a tumor growth model. This system has been investigated in previous contributions from the…

Analysis of PDEs · Mathematics 2018-11-26 Andrea Signori

Image inpainting involves filling in damaged or missing regions of an image by utilizing information from the surrounding areas. In this paper, we investigate a highly nonlinear partial differential equation inspired by the modified…

Analysis of PDEs · Mathematics 2024-10-29 Darko Mitrovic , Andrej Novak

In the recent paper `Well-posedness and regularity for a generalized fractional Cahn-Hilliard system' (arXiv:1804.11290) by the same authors, general well-posedness results have been established for a a class of evolutionary systems of two…

Analysis of PDEs · Mathematics 2018-10-23 Pierluigi Colli , Gianni Gilardi , Jürgen Sprekels

We consider a non-local tumour growth model of phase-field type, describing the evolution of tumour cells through proliferation in presence of a nutrient. The model consists of a coupled system, incorporating a non-local Cahn-Hilliard…

Analysis of PDEs · Mathematics 2024-07-29 Matteo Fornoni

This paper investigates an optimal control problem associated with a two-dimensional multi-species Cahn-Hilliard-Keller-Segel tumor growth model, which incorporates complex biological processes such as species diffusion, chemotaxis,…

Analysis of PDEs · Mathematics 2024-07-26 Pierluigi Colli , Gianni Gilardi , Andrea Signori , Jürgen Sprekels

This paper treats a distributed optimal control problem for a tumor growth model of Cahn-Hilliard type including chemotaxis. The evolution of the tumor fraction is governed by a variational inequality corresponding to a double obstacle…

Optimization and Control · Mathematics 2021-04-21 Pierluigi Colli , Andrea Signori , Jürgen Sprekels

In this paper, we address an optimal distributed control problem for a non-local model of phase-field type, describing the evolution of tumour cells in presence of a nutrient. The model couples a non-local and viscous Cahn-Hilliard equation…

Analysis of PDEs · Mathematics 2023-10-25 Matteo Fornoni
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