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Since its foundations, more than one hundred years ago, the field of structural biology has strived to understand and analyze the properties of molecules and their interactions by studying the structure that they take in 3D space. However,…

Biomolecules · Quantitative Biology 2023-02-27 Gabriele Corso

By co-designing a meta-optical front end in conjunction with an image-processing back end, we demonstrate noise sensitivity and compactness substantially superior to either an optics-only or a computation-only approach, illustrated by two…

The rise of machine learning and additive manufacturing has enabled the design of architected materials with tailored properties that surpass those of natural materials. Inverse design offers a data-efficient alternative to trial-and-error…

Applied Physics · Physics 2026-04-30 Hirak Kansara , Leo Guo , Wei Tan

Relying on either deep models or physical models are two mainstream approaches for solving inverse sample reconstruction problems in programmable illumination computational microscopy. Solutions based on physical models possess strong…

Image and Video Processing · Electrical Eng. & Systems 2024-03-21 Ruiqing Sun , Delong Yang , Shaohui Zhang , Qun Hao

Shape-morphing structures possess the ability to change their shapes from one state to another, and therefore, offer great potential for a broad range of applications. A typical paradigm of morphing is transforming from an initial…

Applied Physics · Physics 2023-07-13 Hirak Kansara , Mingchao Liu , Yinfeng He , Wei Tan

Generative models are powerful tools for sampling from a learned distribution $\mathcal{P}(Y \mid X)$, and inverse-design methods invert this map to find an input $x$ that produces a desired point output $y^*$. However, many design goals…

Machine Learning · Computer Science 2026-05-12 Ori Meidler , Shaul Tolkovsky , Or Zuk

Diffusion models have emerged as the new state-of-the-art generative model with high quality samples, with intriguing properties such as mode coverage and high flexibility. They have also been shown to be effective inverse problem solvers,…

Computer Vision and Pattern Recognition · Computer Science 2025-10-06 Hyungjin Chung , Dohoon Ryu , Michael T. McCann , Marc L. Klasky , Jong Chul Ye

Imaging is critical to the characterisation of materials. However, even with careful sample preparation and microscope calibration, imaging techniques are often prone to defects and unwanted artefacts. This is particularly problematic for…

Computer Vision and Pattern Recognition · Computer Science 2022-10-14 Isaac Squires , Samuel J. Cooper , Amir Dahari , Steve Kench

Inverse design of solid-state materials with desired properties represents a formidable challenge in materials science. Although recent generative models have demonstrated potential, their adoption has been hindered by limitations such as…

Materials Science · Physics 2024-08-15 Yan Chen , Xueru Wang , Xiaobin Deng , Yilun Liu , Xi Chen , Yunwei Zhang , Lei Wang , Hang Xiao

Finite element methods typically require a high resolution to satisfactorily approximate micro and even macro patterns of an underlying physical model. This issue can be circumvented by appropriate multiscale strategies that are able to…

Numerical Analysis · Mathematics 2025-12-24 Zhi-Song Liu , Roland Maier , Andreas Rupp

Layout designs are encountered in a variety of fields. For problems with many design degrees of freedom, efficiency of design methods becomes a major concern. In recent years, machine learning methods such as artificial neural networks have…

Machine Learning · Computer Science 2021-02-01 Chao Qian , Renkai Tan , Wenjing Ye

Models for image representation learning are typically designed for either recognition or generation. Various forms of contrastive learning help models learn to convert images to embeddings that are useful for classification, detection, and…

Computer Vision and Pattern Recognition · Computer Science 2026-01-21 Matthew Gwilliam , Xiao Wang , Xuefeng Hu , Zhenheng Yang

Inverse design aims to design the input variables of a physical system to optimize a specified objective function, typically formulated as a search or optimization problem. However, in 3D domains, the design space grows exponentially,…

Computer Vision and Pattern Recognition · Computer Science 2025-12-11 Yuze Hao , Linchao Zhu , Yi Yang

We propose and demonstrate a generative deep learning approach for the shape recognition of an arbitrary object from its acoustic scattering properties. The strategy exploits deep neural networks to learn the mapping between the latent…

Sound · Computer Science 2022-07-13 W. W. Ahmed , M. Farhat , P. -Y. Chen , X. Zhang , Y. Wu

Flexible control light field across multiple parameters is the cornerstone of versatile and miniaturized optical devices. Metasurfaces, comprising subwavelength scatterers, offer a potent platform for executing such precise manipulations.…

Nonlinear metamaterials with tailored mechanical properties have applications in engineering, medicine, robotics, and beyond. While modeling their macromechanical behavior is challenging in itself, finding structure parameters that lead to…

Graphics · Computer Science 2023-09-20 Yue Li , Stelian Coros , Bernhard Thomaszewski

Neural reflectance models are capable of reproducing the spatially-varying appearance of many real-world materials at different scales. Unfortunately, existing techniques such as NeuMIP have difficulties handling materials with strong…

Graphics · Computer Science 2024-04-25 Bowen Xue , Shuang Zhao , Henrik Wann Jensen , Zahra Montazeri

Optical metasurfaces have been heralded as the platform to integrate multiple functionalities in a compact form-factor, potentially replacing bulky components. A central stepping stone towards realizing this promise is the demonstration of…

Reconstructing 3D objects from images is inherently an ill-posed problem due to ambiguities in geometry, appearance, and topology. This paper introduces collaborative inverse rendering with persistent homology priors, a novel strategy that…

Computer Vision and Pattern Recognition · Computer Science 2026-01-21 Xiang Gao , Xinmu Wang , Yuanpeng Liu , Yue Wang , Junqi Huang , Wei Chen , Xianfeng Gu

How do diffusion generative models convert pure noise into meaningful images? In a variety of pretrained diffusion models (including conditional latent space models like Stable Diffusion), we observe that the reverse diffusion process that…

Computer Vision and Pattern Recognition · Computer Science 2024-03-27 Binxu Wang , John J. Vastola