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Large Language Models (LLMs) have shown promising performance on diverse medical benchmarks, highlighting their potential in supporting real-world clinical tasks. Retrieval-Augmented Generation (RAG) has emerged as a key approach for…

Computation and Language · Computer Science 2025-09-30 Kaishuai Xu , Wenjun Hou , Yi Cheng , Wenjie Li

Large Language Models (LLMs) demonstrate strong conversational abilities. In this Working Paper, we study them in the context of debating in two ways: their ability to perform in a structured debate along with a dataset of arguments to use…

Information Retrieval · Computer Science 2025-07-15 Anthony Miyaguchi , Conor Johnston , Aaryan Potdar

Large Language Models (LLMs) have swiftly emerged as vital resources for different applications in the biomedical and healthcare domains; however, these models encounter issues such as generating inaccurate information or hallucinations.…

Computation and Language · Computer Science 2024-05-06 Mingchen Li , Halil Kilicoglu , Hua Xu , Rui Zhang

Large Language Models (LLMs) have shown remarkable capabilities in general domains but often struggle with tasks requiring specialized knowledge. Conventional Retrieval-Augmented Generation (RAG) techniques typically retrieve external…

Computation and Language · Computer Science 2025-02-20 Yucheng Shi , Tianze Yang , Canyu Chen , Quanzheng Li , Tianming Liu , Xiang Li , Ninghao Liu

Recent proprietary large language models (LLMs), such as GPT-4, have achieved a milestone in tackling diverse challenges in the biomedical domain, ranging from multiple-choice questions to long-form generations. To address challenges that…

Computation and Language · Computer Science 2024-06-19 Minbyul Jeong , Jiwoong Sohn , Mujeen Sung , Jaewoo Kang

The development of large language models (LLMs) has brought unprecedented possibilities for artificial intelligence (AI) based medical diagnosis. However, the application perspective of LLMs in real diagnostic scenarios is still unclear…

Computation and Language · Computer Science 2024-05-21 Zhoujian Sun , Cheng Luo , Ziyi Liu , Zhengxing Huang

The deployment of Large Language Models (LLMs) in mental health counseling faces the dual challenges of hallucinations and lack of empathy. While the former may be mitigated by RAG (retrieval-augmented generation) by anchoring answers in…

Computation and Language · Computer Science 2026-01-06 Md Abdullah Al Kafi , Raka Moni , Sumit Kumar Banshal

Retrieval-augmented generation (RAG) enhances the question-answering (QA) abilities of large language models (LLMs) by integrating external knowledge. However, adapting general-purpose RAG systems to specialized fields such as science and…

Computation and Language · Computer Science 2025-01-28 Ran Xu , Hui Liu , Sreyashi Nag , Zhenwei Dai , Yaochen Xie , Xianfeng Tang , Chen Luo , Yang Li , Joyce C. Ho , Carl Yang , Qi He

Large language models (LLMs) have shown remarkable performance on many tasks in different domains. However, their performance in closed-book biomedical machine reading comprehension (MRC) has not been evaluated in depth. In this work, we…

Computation and Language · Computer Science 2024-10-28 Shubham Vatsal , Ayush Singh

The process of matching patients with suitable clinical trials is essential for advancing medical research and providing optimal care. However, current approaches face challenges such as data standardization, ethical considerations, and a…

Computation and Language · Computer Science 2023-08-08 Jiayi Yuan , Ruixiang Tang , Xiaoqian Jiang , Xia Hu

As mental health issues continue to rise globally, there is an increasing demand for accessible and scalable therapeutic solutions. Many individuals currently seek support from Large Language Models (LLMs), even though these models have not…

Computation and Language · Computer Science 2026-03-05 Navdeep Singh Bedi , Ana-Maria Bucur , Noriko Kando , Fabio Crestani

A Comparison of Independent and Joint Fine-tuning Strategies for Retrieval-Augmented Generation Download PDF Neal Gregory Lawton, Alfy Samuel, Anoop Kumar, Daben Liu Published: 20 Aug 2025, Retrieval augmented generation (RAG) is a popular…

Computation and Language · Computer Science 2025-10-21 Neal Gregory Lawton , Alfy Samuel , Anoop Kumar , Daben Liu

Background: Large Language Models (LLMs) are transforming artificial intelligence applications in healthcare due to their ability to understand, generate, and summarize complex medical text. They offer valuable support to clinicians,…

Computation and Language · Computer Science 2026-04-14 Subin Santhosh , Farwa Abbas , Hussain Ahmad , Claudia Szabo

In the evolving landscape of conversational AI, generating concise, context-aware, and human-like dialogue using small and medium-sized language models (LLMs) remains a complex challenge. This study investigates the influence of LoRA rank,…

Computation and Language · Computer Science 2025-04-15 Chitranshu Harbola , Anupam Purwar

Retrieval Augmented Generation (RAG) complements the knowledge of Large Language Models (LLMs) by leveraging external information to enhance response accuracy for queries. This approach is widely applied in several fields by taking its…

This paper investigates the impact of domain-specific model fine-tuning and of reasoning mechanisms on the performance of question-answering (Q&A) systems powered by large language models (LLMs) and Retrieval-Augmented Generation (RAG).…

Artificial Intelligence · Computer Science 2024-04-23 Zooey Nguyen , Anthony Annunziata , Vinh Luong , Sang Dinh , Quynh Le , Anh Hai Ha , Chanh Le , Hong An Phan , Shruti Raghavan , Christopher Nguyen

This study introduces a system leveraging Large Language Models (LLMs) to extract text and enhance user interaction with PDF documents via a conversational interface. Utilizing Retrieval-Augmented Generation (RAG), the system provides…

Information Retrieval · Computer Science 2025-02-20 Soham Roy , Mitul Goswami , Nisharg Nargund , Suneeta Mohanty , Prasant Kumar Pattnaik

In the face of rapidly expanding online medical literature, automated systems for aggregating and summarizing information are becoming increasingly crucial for healthcare professionals and patients. Large Language Models (LLMs), with their…

Computation and Language · Computer Science 2024-03-07 Niraj Yagnik , Jay Jhaveri , Vivek Sharma , Gabriel Pila

Practitioners deploying small open-weight large language models (LLMs) for medical question answering face a recurring design choice: invest in a domain-fine-tuned model, or keep a general-purpose model and inject domain knowledge at…

Computation and Language · Computer Science 2026-04-28 Avi-ad Avraam Buskila

Applications of generative Large Language Models LLMs are rapidly expanding across various domains, promising significant improvements in workflow efficiency and information retrieval. However, their implementation in specialized,…

Computation and Language · Computer Science 2025-04-10 Chad Melton , Alex Sorokine , Steve Peterson