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The integration of Large Language Models (LLMs) into the drug discovery and development field marks a significant paradigm shift, offering novel methodologies for understanding disease mechanisms, facilitating drug discovery, and optimizing…

Quantitative Methods · Quantitative Biology 2024-09-10 Yizhen Zheng , Huan Yee Koh , Maddie Yang , Li Li , Lauren T. May , Geoffrey I. Webb , Shirui Pan , George Church

The rapid development of Artificial Intelligence (AI) has revolutionized numerous fields, with large language models (LLMs) and computer vision (CV) systems driving advancements in natural language understanding and visual processing,…

Computation and Language · Computer Science 2024-12-04 Yunkai Dang , Kaichen Huang , Jiahao Huo , Yibo Yan , Sirui Huang , Dongrui Liu , Mengxi Gao , Jie Zhang , Chen Qian , Kun Wang , Yong Liu , Jing Shao , Hui Xiong , Xuming Hu

This paper presents a comprehensive performance evaluation of Large Language Models (LLMs) in solving programming challenges from Leetcode, a widely used platform for algorithm practice and technical interviews. We began by crawling the…

Software Engineering · Computer Science 2025-03-04 Lun Wang , Chuanqi Shi , Shaoshui Du , Yiyi Tao , Yixian Shen , Hang Zheng , Yanxin Shen , Xinyu Qiu

Large language models (LLMs) are increasingly embedded in AI-based tutoring systems. Can they faithfully model novice reasoning and metacognitive judgments? Existing evaluations emphasize problem-solving accuracy, overlooking the fragmented…

Computation and Language · Computer Science 2026-05-12 Conrad Borchers , Jill-Jênn Vie , Roger Azevedo

Large language models (LLMs) have undergone significant expansion and have been increasingly integrated across various domains. Notably, in the realm of robot task planning, LLMs harness their advanced reasoning and language comprehension…

Large Language Models (LLMs) have achieved remarkable success in source code understanding, yet as software systems grow in scale, computational efficiency has become a critical bottleneck. Currently, these models rely on a text-based…

Computation and Language · Computer Science 2026-04-29 Yuling Shi , Chaoxiang Xie , Zhensu Sun , Yeheng Chen , Chenxu Zhang , Longfei Yun , Chengcheng Wan , Hongyu Zhang , David Lo , Xiaodong Gu

Large Language Models (LLMs) have demonstrated impressive progress in complex reasoning tasks, largely driven by the Chain-of-Thought (CoT) paradigm, which decomposes difficult problems into intermediate steps. However, CoT reasoning…

Symbolic Computation · Computer Science 2026-05-26 Rui Wang , Zeming Wei , Yihao Zhang , Xiaokun Luan

Despite rapid advances in Large Language Models and Multimodal Large Language Models (LLMs), numerous challenges related to interpretability, scalability, resource requirements and repeatability remain, related to their application in the…

Software Engineering · Computer Science 2025-07-23 Sohaib Muhammad , Ashwati Vipin , Karan Shetti , Honey Mittal

Robotic path planning problems are often NP-hard, and practical solutions typically rely on approximation algorithms with provable performance guarantees for general cases. While designing such algorithms is challenging, formally proving…

Robotics · Computer Science 2026-03-23 Zhengbang Yang , Md. Tasin Tazwar , Minghan Wei , Zhuangdi Zhu

Logical reasoning, i.e., deductively inferring the truth value of a conclusion from a set of premises, is an important task for artificial intelligence with wide potential impacts on science, mathematics, and society. While many…

Computation and Language · Computer Science 2024-02-15 Theo X. Olausson , Alex Gu , Benjamin Lipkin , Cedegao E. Zhang , Armando Solar-Lezama , Joshua B. Tenenbaum , Roger Levy

This paper investigates the capabilities of large language models (LLMs) in formulating and solving decision-making problems using mathematical programming. We first conduct a systematic review and meta-analysis of recent literature to…

Artificial Intelligence · Computer Science 2025-08-26 Mohammad J. Abdel-Rahman , Yasmeen Alslman , Dania Refai , Amro Saleh , Malik A. Abu Loha , Mohammad Yahya Hamed

Generative Large Language Models (LLMs) hold significant promise in healthcare, demonstrating capabilities such as passing medical licensing exams and providing clinical knowledge. However, their current use as information retrieval tools…

We introduce SIMCOPILOT, a benchmark that simulates the role of large language models (LLMs) as interactive, "copilot"-style coding assistants. Targeting both completion (finishing incomplete methods or code blocks) and infill tasks…

Machine Learning · Computer Science 2025-05-29 Mingchao Jiang , Abhinav Jain , Sophia Zorek , Chris Jermaine

The field of machine learning (ML) has gained widespread adoption, leading to significant demand for adapting ML to specific scenarios, which is yet expensive and non-trivial. The predominant approaches towards the automation of solving ML…

Machine Learning · Computer Science 2024-02-20 Lei Zhang , Yuge Zhang , Kan Ren , Dongsheng Li , Yuqing Yang

The rapid rise of Large Language Models (LLMs) has changed software development, with tools like Copilot, JetBrains AI Assistant, and others boosting developers' productivity. However, developers now spend more time reviewing code than…

Software Engineering · Computer Science 2024-07-08 Agnia Sergeyuk , Olga Lvova , Sergey Titov , Anastasiia Serova , Farid Bagirov , Timofey Bryksin

Large language models (LLMs) have greatly improved their capability in performing NLP tasks. However, deeper semantic understanding, contextual coherence, and more subtle reasoning are still difficult to obtain. The paper discusses…

Computation and Language · Computer Science 2025-12-05 Mohanakrishnan Hariharan

With the advent of large language models (LLMs), in both the open source and proprietary domains, attention is turning to how to exploit such artificial intelligence (AI) systems in assisting complex scientific tasks, such as material…

Human-Computer Interaction · Computer Science 2024-01-26 Yongtao Liu , Marti Checa , Rama K. Vasudevan

Natural language understanding requires interleaving textual and logical reasoning, yet large language models often fail to perform such reasoning reliably. Existing neurosymbolic systems combine LLMs with solvers but remain limited to…

Artificial Intelligence · Computer Science 2026-02-23 Hyunseok Oh , Sam Stern , Youngki Lee , Matthai Philipose

As software grows in complexity to accommodate diverse features and platforms, software bloating has emerged as a significant challenge, adversely affecting performance and security. However, existing approaches inadequately address the…

Software Engineering · Computer Science 2025-03-13 Bo Lin , Shangwen Wang , Yihao Qin , Liqian Chen , Xiaoguang Mao

The telecommunications and networking domain stands at the precipice of a transformative era, driven by the necessity to manage increasingly complex, hierarchical, multi administrative domains (i.e., several operators on the same path) and…

Networking and Internet Architecture · Computer Science 2025-06-30 Viswanath Kumarskandpriya , Abdulhalim Dandoush , Abbas Bradai , Ali Belgacem
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