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Identifying DNA- (DBPs) and RNA-binding proteins (RBPs) is crucial for the understanding of cell function, molecular interactions as well as regulatory functions. Owing to their high similarity, most of the existing approaches face…

Quantitative Methods · Quantitative Biology 2025-10-22 Nimisha Ghosh , Dheeran Sankaran , Rahul Balakrishnan Adhi , Sharath S , Amrut Anand

Sequences of nucleotides (for DNA and RNA) or amino acids (for proteins) are central objects in biology. Among the most important computational problems is that of sequence alignment, i.e. arranging sequences from different organisms in…

Quantitative Methods · Quantitative Biology 2020-12-08 Anna Paola Muntoni , Andrea Pagnani , Martin Weigt , Francesco Zamponi

Face recognition systems have raised concerns due to their vulnerability to different presentation attacks, and system security has become an increasingly critical concern. Although many face anti-spoofing (FAS) methods perform well in…

Computer Vision and Pattern Recognition · Computer Science 2024-01-03 Zhe Kong , Wentian Zhang , Tao Wang , Kaihao Zhang , Yuexiang Li , Xiaoying Tang , Wenhan Luo

Enzymes and proteins are live driven biochemicals, which has a dramatic impact over the environment, in which it is active. So, therefore, it is highly looked-for to build such a robust and highly accurate automatic and computational model…

Biomolecules · Quantitative Biology 2021-01-11 Zaheer Ullah Khan , Dechang Pi , Izhar Ahmed Khan , Asif Nawaz , Jamil Ahmad , Mushtaq Hussain

The task of predicting dialog acts (DA) based on conversational dialog is a key component in the development of conversational agents. Accurately predicting DAs requires a precise modeling of both the conversation and the global tag…

Computation and Language · Computer Science 2020-02-27 Pierre Colombo , Emile Chapuis , Matteo Manica , Emmanuel Vignon , Giovanna Varni , Chloe Clavel

Protein interactions are important in a broad range of biological processes. Traditionally, computational methods have been developed to automatically predict protein interface from hand-crafted features. Recent approaches employ deep…

Machine Learning · Computer Science 2020-07-21 Yi Liu , Hao Yuan , Lei Cai , Shuiwang Ji

The Transformer, a breakthrough architecture in artificial intelligence, owes its success to the attention mechanism, which utilizes long-range interactions in sequential data, enabling the emergent coherence between large language models…

Artificial Intelligence · Computer Science 2026-04-23 Zihan Zhou , Bo-Wei Qin , Kai Du , Wei Lin

Despite the impressive performance of current vision-based facial action unit (AU) detection approaches, they are heavily susceptible to the variations across different domains and the cross-domain AU detection methods are under-explored.…

Computer Vision and Pattern Recognition · Computer Science 2025-03-13 Yong Li , Menglin Liu , Zhen Cui , Yi Ding , Yuan Zong , Wenming Zheng , Shiguang Shan , Cuntai Guan

Active Domain Adaptation (ADA) aims to maximally boost model adaptation in a new target domain by actively selecting a limited number of target data to annotate.This setting neglects the more practical scenario where training data are…

Artificial Intelligence · Computer Science 2023-11-23 Wenqiao Zhang , Zheqi Lv , Hao Zhou , Jia-Wei Liu , Juncheng Li , Mengze Li , Siliang Tang , Yueting Zhuang

Deep Learning (DL) algorithms hold great promise for applications in the field of computational biophysics. In fact, the vast amount of available molecular structures, as well as their notable complexity, constitutes an ideal context in…

Soft Condensed Matter · Physics 2019-01-07 Marco Giulini , Raffaello Potestio

The task of predicting dialog acts (DA) based on conversational dialog is a key component in the development of conversational agents. Accurately predicting DAs requires a precise modeling of both the conversation and the global tag…

Computation and Language · Computer Science 2020-02-27 Pierre Colombo , Emile Chapuis , Matteo Manica , Emmanuel Vignon , Giovanna Varni , Chloe Clavel

Click-Through Rate (CTR) prediction is a pivotal task in product and content recommendation, where learning effective feature embeddings is of great significance. However, traditional methods typically learn fixed feature representations…

Information Retrieval · Computer Science 2023-09-06 Chen Zhu , Liang Du , Hong Chen , Shuang Zhao , Zixun Sun , Xin Wang , Wenwu Zhu

Proteins are essential for maintaining life. For example, knowing the structure of a protein, cell regulatory mechanisms of organisms can be modeled, supporting the development of disease treatments or the understanding of relationships…

Biomolecules · Quantitative Biology 2019-01-07 Daniel Bonetti , Alexandre Delbem , Dorival Leão , Jochen Einbeck

Accurate protein function prediction requires integrating heterogeneous intrinsic signals (e.g., sequence and structure) with noisy extrinsic contexts (e.g., protein-protein interactions and GO term annotations). However, two key challenges…

Machine Learning · Computer Science 2025-10-28 Runjie Zheng , Zhen Wang , Anjie Qiao , Jiancong Xie , Jiahua Rao , Yuedong Yang

Domain adaptation is a popular paradigm in modern machine learning which aims at tackling the problem of divergence (or shift) between the labeled training and validation datasets (source domain) and a potentially large unlabeled dataset…

Machine Learning · Computer Science 2023-11-10 Evgeny M Mirkes , Jonathan Bac , Aziz Fouché , Sergey V. Stasenko , Andrei Zinovyev , Alexander N. Gorban

Vision-Language-Action (VLA) models rely on current observations, including images, language instructions, and robot states, to predict actions and complete tasks. While accurate visual perception is crucial for precise action prediction…

Computer Vision and Pattern Recognition · Computer Science 2026-03-03 Cheng Yang , Jianhao Jiao , Lingyi Huang , Jinqi Xiao , Zhexiang Tang , Yu Gong , Yibiao Ying , Yang Sui , Jintian Lin , Wen Huang , Bo Yuan

Transformer self-attention computes pairwise token interactions, yet protein sequence to phenotype relationships often involve cooperative dependencies among three or more residues that dot product attention does not capture explicitly. We…

Machine Learning · Computer Science 2026-03-13 Shirin Amiraslani , Xin Gao

Surgical phase recognition has become a crucial requirement in laparoscopic surgery, enabling various clinical applications like surgical risk forecasting. Current methods typically identify the surgical phase using individual frame-wise…

Computer Vision and Pattern Recognition · Computer Science 2024-09-11 Kaixiang Yang , Qiang Li , Zhiwei Wang

Peptides play a pivotal role in a wide range of biological activities through participating in up to 40% protein-protein interactions in cellular processes. They also demonstrate remarkable specificity and efficacy, making them promising…

Biomolecules · Quantitative Biology 2024-02-09 Song Yin , Xuenan Mi , Diwakar Shukla

In this study, we propose a Kernel-PCA model designed to capture structure-function relationships in a protein. This model also enables ranking of reaction coordinates according to their impact on protein properties. By leveraging machine…

Computation and Language · Computer Science 2025-03-26 Parisa Mollaei , Amir Barati Farimani