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This research introduces a Machine Learning-centric approach to replicate olfactory experiences, validated through experimental quantification of perfume perception. Key contributions encompass a hybrid model connecting perfume molecular…

Robust and efficient interpretation of QSAR methods is quite useful to validate AI prediction rationales with subjective opinion (chemist or biologist expertise), understand sophisticated chemical or biological process mechanisms, and…

Biomolecules · Quantitative Biology 2026-05-05 Jinjiang Guo , Qi Liu , Han Guo , Xi Lu

The sense of smell is an important part of living organisms. It assists with the interaction of the living organism with its environment. The mechanism by which smell is detected and identified is not fully known. Earlier, shape theory was…

Biological Physics · Physics 2019-11-07 Chukwuemeka Asogwa

Olfaction sensing in autonomous robotics faces challenges in dynamic operations, energy efficiency, and edge processing. It necessitates a machine learning algorithm capable of managing real-world odor interference, ensuring resource…

Signal Processing · Electrical Eng. & Systems 2024-07-09 Rizwana Kausar , Fakhreddine Zayer , Jaime Viegas , Jorge Dias

Digital sensing faces challenges in developing sustainable methods to extend the applicability of customized e-noses to complex body odor volatilome (BOV). To address this challenge, we developed MORE-ML, a computational framework that…

In drug discovery, knowledge of the graph structure of chemical compounds is essential. Many thousands of scientific articles in chemistry and pharmaceutical sciences have investigated chemical compounds, but in cases the details of the…

Machine Learning · Statistics 2020-09-16 Martijn Oldenhof , Adam Arany , Yves Moreau , Jaak Simm

The mechanism by which odorants are recognized by olfactory receptors remains primarily unresolved. While charge transport is believed to play a significant role, its precise nature is still unclear. Here, we present a novel perspective by…

Chemical Physics · Physics 2025-06-30 Dominik Szczȩśniak , Ewa Drzazga-Szczȩśniak , Sabre Kais

Designing a network to learn a molecule structure given its physical/chemical properties is a hard problem, but is useful for drug discovery tasks. In this paper, we incorporate higher-order relational learning of Factor Graphs with strong…

Machine Learning · Computer Science 2020-12-11 Hieu Le Trung , Yiqing Xu , Wee Sun Lee

It is well known that Drug Design is often a costly process both in terms of time and economic effort. While good Quantitative Structure-Activity Relationship models (QSAR) can help predicting molecular properties without the need to…

Biomolecules · Quantitative Biology 2022-02-14 Dylan Savoia , Alessio Ragno , Roberto Capobianco

Studies of insect olfactory processing indicate that odors are represented by rich spatio-temporal patterns of neural activity. These patterns are very difficult to predict a priori, yet they are stimulus specific and reliable upon repeated…

Neurons and Cognition · Quantitative Biology 2007-05-23 M. I. Rabinovich , R. Huerta , A. Volkovskii , Henry D. I. Abarbanel , G. Laurent

Odor sensory evaluation has a broad application in food, clothing, cosmetics, and other fields. Traditional artificial sensory evaluation has poor repeatability, and the machine olfaction represented by the electronic nose (E-nose) is…

Artificial Intelligence · Computer Science 2023-11-27 Xiuxin Xia , Yuchen Guo , Yanwei Wang , Yuchao Yang , Yan Shi , Hong Men

The olfactory system removes correlations in natural odors using a network of inhibitory neurons in the olfactory bulb. It has been proposed that this network integrates the response from all olfactory receptors and inhibits them equally.…

Neurons and Cognition · Quantitative Biology 2022-01-31 David Zwicker

The prediction of odor characters is still impossible based on the odorant molecular structure. We designed a CNN-based regressor for computed parameters in molecular vibrations (CNN\_vib), in order to investigate the ability to predict…

Chemical Physics · Physics 2025-09-23 Yuki Harada , Shuichi Maeda , Junwei Shen , Taku Misonou , Hirokazu Hori , Shinichiro Nakamura

Accurate prediction of molecular properties is essential in drug discovery and related fields. However, existing graph neural networks (GNNs) often struggle to simultaneously capture both local and global molecular structures. In this work,…

Machine Learning · Computer Science 2025-08-26 XiaYu Liu , Chao Fan , Yang Liu , Hou-biao Li

Olfactory systems use a small number of broadly sensitive receptors to combinatorially encode a vast number of odors. We propose a method of decoding such distributed representations by exploiting a statistical fact: receptors that do not…

Neurons and Cognition · Quantitative Biology 2021-09-01 Vijay Singh , Martin Tchernookov , Vijay Balasubramanian

In this paper, we propose a novel concept for engineered molecular communication (MC) systems inspired by animal olfaction. We focus on a multi-user scenario where several transmitters wish to communicate with a central receiver. We assume…

Information Theory · Computer Science 2022-03-09 Vahid Jamali , Helene M. Loos , Andrea Buettner , Robert Schober , H. Vincent Poor

This paper studies the usefulness of incorporating path information in predicting chemical properties from molecular graphs, in the domain of QSAR (Quantitative Structure-Activity Relationship). Towards this, we developed a GNN-style model…

Biomolecules · Quantitative Biology 2024-07-22 Abdulrahman Ibraheem , Narsis Kiani , Jesper Tegner

Molecular structure-property relationships are key to molecular engineering for materials and drug discovery. The rise of deep learning offers a new viable solution to elucidate the structure-property relationships directly from chemical…

Machine Learning · Computer Science 2018-10-09 Seongok Ryu , Jaechang Lim , Seung Hwan Hong , Woo Youn Kim

In this paper, we propose a novel concept for engineered molecular communication (MC) systems inspired by animal olfaction. We focus on a multi-user scenario where transmitters employ unique mixtures of different types of signaling…

Information Theory · Computer Science 2022-04-19 Vahid Jamali , Helene M. Loos , Andrea Buettner , Robert Schober , H. Vincent Poor

We present a model of an olfactory system that performs odor segmentation. Based on the anatomy and physiology of natural olfactory systems, it consists of a pair of coupled modules, bulb and cortex. The bulb encodes the odor inputs as…

Disordered Systems and Neural Networks · Physics 2007-05-23 Zhaoping Li , John Hertz