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In this work we study a fractional SEIR biological model of a reaction-diffusion, using the non-singular kernel Caputo-Fabrizio fractional derivative in the Caputo sense and employing the Laplacian operator. In our PDE model, the government…

Dynamical Systems · Mathematics 2025-05-13 Achraf Zinihi , Moulay Rchid Sidi Ammi , Matthias Ehrhardt

The main aim of the present work is to study and analyze a reaction-diffusion fractional version of the SIR epidemic mathematical model by means of the non-local and non-singular ABC fractional derivative operator with complete memory…

Optimization and Control · Mathematics 2022-01-26 Moulay Rchid Sidi Ammi , Mostafa Tahiri , Delfim F. M. Torres

This article presents the solution of the fractional SIR epidemic model using the Laplace residual power series method. We introduce the fractional SIR model in the sense of Caputo's derivative, it is presented by three fractional…

Quantitative Methods · Quantitative Biology 2023-06-21 Ahmad Qazza , Rania Saadeh

We study a linear-quadratic optimal control problem involving a parabolic equation with fractional diffusion and Caputo fractional time derivative of orders $s \in (0,1)$ and $\gamma \in (0,1]$, respectively. The spatial fractional…

Optimization and Control · Mathematics 2015-04-02 Harbir Antil , Enrique Otarola , Abner J. Salgado

In this paper, we consider an optimal distributed control problem for a reaction-diffusion-based SIR epidemic model with human behavioral effects. We develop a model wherein non-pharmaceutical intervention methods are implemented, but a…

Analysis of PDEs · Mathematics 2025-02-11 Marcelo Bongarti , Christian Parkinson , Weinan Wang

Epidemiological modeling is vital in understanding disease dynamics and guiding public health interventions. This study presents a time-fractional SEIR model to describe the transmission dynamics of Mpox, incorporating memory effects via…

Numerical Analysis · Mathematics 2026-01-29 Gaurav Saini , Bappa Ghosh , Sunita Chand , Jugal Mohapatra

We propose and study an optimal control model for malaria infection described by system of fractional differential equations. The model is formulated in terms of the left and right Caputo fractional derivatives. We determine the necessary…

Dynamical Systems · Mathematics 2016-07-07 E. Okyere , F. T. Oduro , S. K. Amponsah , I. K. Dontwi

This paper introduces a spatiotemporal SEIQR epidemic model governed by a system of reaction-diffusion partial differential equations that incorporates optimal control strategies. The model captures the transmission dynamics of an…

Dynamical Systems · Mathematics 2025-07-29 Achraf Zinihi , Matthias Ehrhardt , Moulay Rchid Sidi Ammi

Over the past several decades there has been a proliferation of epidemiological models with ordinary derivatives replaced by fractional derivatives in an an-hoc manner. These models may be mathematically interesting but their relevance is…

Populations and Evolution · Quantitative Biology 2016-03-31 C. N. Angstmann , B. I. Henry , A. V. McGann

In this paper, we prove the global-in-time existence of strong solutions to a class of fractional parabolic reaction-diffusion systems set in a bounded open subset of $\mathbb{R}^N$. The diffusion operators are of the form $u_i \mapsto d_i…

Analysis of PDEs · Mathematics 2026-03-10 Maha Daoud

A Caputo-type fractional-order mathematical model for "metapopulation cholera transmission" was recently proposed in [Chaos Solitons Fractals 117 (2018), 37--49]. A sensitivity analysis of that model is done here to show the accuracy…

Optimization and Control · Mathematics 2021-12-08 Silverio Rosa , Delfim F. M. Torres

We investigate the celebrated mathematical SICA model but using fractional differential equations in order to better describe the dynamics of HIV-AIDS infection. The infection process is modelled by a general functional response and the…

Optimization and Control · Mathematics 2021-01-21 Adnane Boukhouima , El Mehdi Lotfi , Marouane Mahrouf , Silverio Rosa , Delfim F. M. Torres , Noura Yousfi

Research focus on optimal control problems brought on by fractional differential equations has been extensively applied in practice. However, because they are still open-ended and challenging, a number of problems with fractional…

Populations and Evolution · Quantitative Biology 2023-04-25 Samuel Okyere , Joseph Ackora-Prah , Kwaku Forkuoh Darkwah , Francis Tabi Oduro , Ebenezer Bonyah

We consider the problem of controlling an SIR-model epidemic by temporarily reducing the rate of contact within a population. The control takes the form of a multiplicative reduction in the contact rate of infectious individuals. The…

Optimization and Control · Mathematics 2021-06-29 David I. Ketcheson

This paper analyses the optimal control of infectious disease propagation using a classic susceptible-infected-recovered (SIR) model characterised by permanent immunity and the absence of available vaccines. The control is performed over a…

Optimization and Control · Mathematics 2024-06-12 Rocío Balderrama , Mariana Inés Prieto , Constanza Sánchez de la Vega , Federico Vazquez

This article provides a brief review of recent developments on two nonlocal operators: fractional Laplacian and fractional time derivative. We start by accounting for several applications of these operators in imaging science, geophysics,…

Optimization and Control · Mathematics 2021-06-28 Harbir Antil , Thomas S. Brown , Ratna Khatri , Akwum Onwunta , Deepanshu Verma , Mahamadi Warma

We propose a mathematical spatiotemporal epidemic SICA model with a control strategy. The spatial behavior is modeled by adding a diffusion term with the Laplace operator, which is justified and interpreted both mathematically and…

Optimization and Control · Mathematics 2022-07-12 Houssine Zine , Abderrahim El Adraoui , Delfim F. M. Torres

We investigate a susceptible-infected-susceptible (SIS) epidemic model based on the Caputo-Fabrizio operator. After performing an asymptotic analysis of the system, we study a related finite horizon optimal control problem with state…

Analysis of PDEs · Mathematics 2021-07-29 Simone Cacace , Anna Chiara Lai , Paola Loreti

The SEIR model is a compartmental model used to simulate the dynamics of an epidemic. In this chapter, we introduce two control functions in the compartmental SEIR model representing vaccination and plasma transfusion. Optimal control…

Optimization and Control · Mathematics 2021-07-23 Juliana Couras , Ivan Area , Juan J. Nieto , Cristiana J. Silva , Delfim F. M. Torres

A Caputo fractional-order mathematical model for the transmission dynamics of tuberculosis (TB) was recently proposed in [Math. Model. Nat. Phenom. 13 (2018), no. 1, Art. 9]. Here, a sensitivity analysis of that model is done, showing the…

Optimization and Control · Mathematics 2019-08-12 Silverio Rosa , Delfim F. M. Torres
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