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The gold standard for identifying causal relationships is a randomized controlled experiment. In many applications in the social sciences and medicine, the researcher does not control the assignment mechanism and instead may rely upon…

Applications · Statistics 2016-11-22 Johann Gagnon-Bartsch , Yotam Shem-Tov

We propose a new method named the Conditional Randomization Rank Test (CRRT) for testing conditional independence of a response variable Y and a covariate variable X, conditional on the rest of the covariates Z. The new method generalizes…

Methodology · Statistics 2021-12-02 Yanjie Zhong , Todd Kuffner , Soumendra Lahiri

In qualitative statistics, permutation tests are very popular, mainly because of their finite-sample exactness under exchangeability. However, in non-exchangeable settings, the covariance structure of permuted statistics typically differs…

Methodology · Statistics 2026-04-09 Merle Munko , Paavo Sattler

It is common to conduct causal inference in matched observational studies by proceeding as though treatment assignments within matched sets are assigned uniformly at random and using this distribution as the basis for inference. This…

Methodology · Statistics 2023-11-14 Samuel D. Pimentel , Yaxuan Huang

The advent of modern data collection and processing techniques has seen the size, scale, and complexity of data grow exponentially. A seminal step in leveraging these rich datasets for downstream inference is understanding the…

Applications · Statistics 2024-07-30 Zeyi Wang , Eric Bridgeford , Shangsi Wang , Joshua T. Vogelstein , Brian Caffo

There has been a wide interest to extend univariate and multivariate nonparametric procedures to clustered and hierarchical data. Traditionally, parametric mixed models have been used to account for the correlation structures among the…

Statistics Theory · Mathematics 2018-03-02 Jaakko Nevalainen , Denis Larocque , Hannu Oja , Ilkka Pörsti

The problem of detecting changes in covariance for a single pair of features has been studied in some detail, but may be limited in importance or general applicability. In contrast, testing equality of covariance matrices of a {\it set} of…

Methodology · Statistics 2017-12-12 Yi-Hui Zhou

This article carries out a large dimensional analysis of standard regularized discriminant analysis classifiers designed on the assumption that data arise from a Gaussian mixture model with different means and covariances. The analysis…

Machine Learning · Statistics 2019-06-19 Khalil Elkhalil , Abla Kammoun , Romain Couillet , Tareq Y. Al-Naffouri , Mohamed-Slim Alouini

The primary analysis for longitudinal randomized controlled trials (RCTs) often compares treatment groups at the last timepoint, referred to as the landmark time. Assuming data are normally distributed and missing at random, the mixed model…

Methodology · Statistics 2026-03-18 Guangyong Zou , Shi-Fang Qui , Joshua Zou , Emma Davies Smith , Yun-Hee Choi , Yuhan Bi

Permutation tests are widely recognized as robust alternatives to tests based on normal theory. Random permutation tests have been frequently employed to assess the significance of variables in linear models. Despite their widespread use,…

Methodology · Statistics 2023-12-29 Leying Guan

Bimodal truncated count distributions are frequently observed in aggregate survey data and in user ratings when respondents are mixed in their opinion. They also arise in censored count data, where the highest category might create an…

Methodology · Statistics 2014-01-24 Pragya Sur , Galit Shmueli , Smarajit Bose , Paromita Dubey

Multiple hypothesis testing (MHT) frequently arises in scientific inquiries, and concurrent testing of multiple hypotheses inflates the risk of Type-I errors or false positives, rendering MHT corrections essential. This paper addresses MHT…

Paired cluster-randomized experiments (pCRTs) are common across many disciplines because there is often natural clustering of individuals, and paired randomization can help balance baseline covariates to improve experimental precision.…

Methodology · Statistics 2024-07-03 Charlotte Z. Mann , Adam C. Sales , Johann A. Gagnon-Bartsch

Confounding is a significant obstacle to unbiased estimation of causal effects from observational data. For settings with high-dimensional covariates -- such as text data, genomics, or the behavioral social sciences -- researchers have…

Artificial Intelligence · Computer Science 2024-02-01 Katherine A. Keith , Sergey Feldman , David Jurgens , Jonathan Bragg , Rohit Bhattacharya

We consider testing multivariate conditional independence between a response Y and a covariate vector X given additional variables Z. We introduce the Multivariate Sufficient Statistic Conditional Randomization Test (MS-CRT), which…

Methodology · Statistics 2025-04-10 Xiaotong Lin , Jie Xie , Fangqiao Tian , Dongming Huang

Conditional independence tests are crucial across various disciplines in determining the independence of an outcome variable $Y$ from a treatment variable $X$, conditioning on a set of confounders $Z$. The Conditional Randomization Test…

Methodology · Statistics 2024-05-30 Bowen Xu , Yiwen Huang , Chuan Hong , Shuangning Li , Molei Liu

The Model Parameter Randomisation Test (MPRT) is widely acknowledged in the eXplainable Artificial Intelligence (XAI) community for its well-motivated evaluative principle: that the explanation function should be sensitive to changes in the…

Artificial Intelligence · Computer Science 2024-01-15 Anna Hedström , Leander Weber , Sebastian Lapuschkin , Marina MC Höhne

In randomized experiments with noncompliance, tests may focus on compliers rather than on the overall sample. Rubin (1998) put forth such a method, and argued that testing for the complier average causal effect and averaging permutation…

Methodology · Statistics 2016-02-23 Laura Forastiere , Fabrizia Mealli , Luke Miratrix

In this paper, we propose a general framework for distribution-free nonparametric testing in multi-dimensions, based on a notion of multivariate ranks defined using the theory of measure transportation. Unlike other existing proposals in…

Statistics Theory · Mathematics 2019-10-08 Nabarun Deb , Bodhisattva Sen

Mixed linear models are commonly used in repeated measures studies. They account for the dependence amongst observations obtained from the same experimental unit. Oftentimes, the number of observations is small, and it is thus important to…

Methodology · Statistics 2011-08-05 Tatiane F. N. Melo , Silvia L. P. Ferrari , Francisco Cribari-Neto
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