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The histopathological analysis of whole-slide images (WSIs) is fundamental to cancer diagnosis but is a time-consuming and expert-driven process. While deep learning methods show promising results, dominant patch-based methods artificially…

Image and Video Processing · Electrical Eng. & Systems 2025-10-08 Alexander Weers , Alexander H. Berger , Laurin Lux , Peter Schüffler , Daniel Rueckert , Johannes C. Paetzold

Self-attention has recently been adopted for a wide range of sequence modeling problems. Despite its effectiveness, self-attention suffers from quadratic compute and memory requirements with respect to sequence length. Successful approaches…

Machine Learning · Computer Science 2020-10-27 Aurko Roy , Mohammad Saffar , Ashish Vaswani , David Grangier

Transformer has been widely used in histopathology whole slide image (WSI) classification for the purpose of tumor grading, prognosis analysis, etc. However, the design of token-wise self-attention and positional embedding strategy in the…

Computer Vision and Pattern Recognition · Computer Science 2022-06-28 Yushan Zheng , Jun Li , Jun Shi , Fengying Xie , Zhiguo Jiang

Transformer models are computationally costly on long sequences since regular attention has quadratic $O(n^2)$ time complexity. We introduce Wavelet-Enhanced Random Spectral Attention (WERSA), a novel mechanism of linear $O(n)$ time…

Machine Learning · Computer Science 2025-07-14 Vincenzo Dentamaro

Long-context ability, has become one of the most important iteration direction of next-generation Large Language Models, particularly in semantic understanding/reasoning, code agentic intelligence and recommendation system. However, the…

The attention mechanism has been the core component in modern transformer architectures. However, the computation of standard full attention scales quadratically with the sequence length, serving as a major bottleneck in long-context…

Computation and Language · Computer Science 2026-04-28 Yusheng Zhao , Hourun Li , Bohan Wu , Yichun Yin , Lifeng Shang , Jingyang Yuan , Meng Zhang , Ming Zhang

Transformer-based models have emerged as one of the most widely used architectures for natural language processing, natural language generation, and image generation. The size of the state-of-the-art models has increased steadily reaching…

Hardware Architecture · Computer Science 2025-01-15 Rya Sanovar , Srikant Bharadwaj , Renee St. Amant , Victor Rühle , Saravan Rajmohan

Deep neural networks are increasingly applied in automated histopathology. Yet, whole-slide images (WSIs) are often acquired at gigapixel sizes, rendering them computationally infeasible to analyze entirely at high resolution. Diagnostic…

Image and Video Processing · Electrical Eng. & Systems 2026-02-10 Tarun G , Naman Malpani , Gugan Thoppe , Sridharan Devarajan

The landscape of computational building blocks of efficient image restoration architectures is dominated by a combination of convolutional processing and various attention mechanisms. However, convolutional filters, while efficient, are…

Image and Video Processing · Electrical Eng. & Systems 2025-01-23 Mohammad Shahab Sepehri , Zalan Fabian , Mahdi Soltanolkotabi

In the era of deep learning, data is the critical determining factor in the performance of neural network models. Generating large datasets suffers from various difficulties such as scalability, cost efficiency and photorealism. To avoid…

Computer Vision and Pattern Recognition · Computer Science 2022-10-04 Chahat Deep Singh , Riya Kumari , Cornelia Fermüller , Nitin J. Sanket , Yiannis Aloimonos

Nucleus detection in histopathology whole slide images (WSIs) is crucial for a broad spectrum of clinical applications. The gigapixel size of WSIs necessitates the use of sliding window methodology for nucleus detection. However, mainstream…

Image and Video Processing · Electrical Eng. & Systems 2026-02-10 Zhongyi Shui , Honglin Li , Yunlong Zhang , Yuxuan Sun , Yiwen Ye , Pingyi Chen , Ruizhe Guo , Lei Cui , Chenglu Zhu , Lin Yang

Automatic medical image segmentation has wide applications for disease diagnosing. However, it is much more challenging than natural optical image segmentation due to the high-resolution of medical images and the corresponding huge…

Computer Vision and Pattern Recognition · Computer Science 2020-12-18 Ziqiang Li , Rentuo Tao , Qianrun Wu , Bin Li

Accurate classification of Whole Slide Images (WSIs) and Regions of Interest (ROIs) is a fundamental challenge in computational pathology. While mainstream approaches often adopt Multiple Instance Learning (MIL), they struggle to capture…

Computer Vision and Pattern Recognition · Computer Science 2025-08-08 Mingxi Fu , Xitong Ling , Yuxuan Chen , Jiawen Li , fanglei fu , Huaitian Yuan , Tian Guan , Yonghong He , Lianghui Zhu

Objective. Limited access to breast cancer diagnosis globally leads to delayed treatment. Ultrasound, an effective yet underutilized method, requires specialized training for sonographers, which hinders its widespread use. Approach. Volume…

Image and Video Processing · Electrical Eng. & Systems 2023-11-21 Donya Khaledyan , Thomas J. Marini , Avice OConnell , Steven Meng , Jonah Kan , Galen Brennan , Yu Zhao , Timothy M. Baran , Kevin J. Parker

Large Language Models (LLMs) encounter significant performance bottlenecks in long-sequence tasks due to the computational complexity and memory overhead inherent in the self-attention mechanism. To address these challenges, we introduce…

Artificial Intelligence · Computer Science 2026-02-17 Ziming Wang , Xiang Wang , Kailong Peng , Lang Qin , Juan Gabriel Kostelec , Christos Sourmpis , Axel Laborieux , Qinghai Guo

In recent years, the availability of digitized Whole Slide Images (WSIs) has enabled the use of deep learning-based computer vision techniques for automated disease diagnosis. However, WSIs present unique computational and algorithmic…

Image and Video Processing · Electrical Eng. & Systems 2021-06-15 Yash Sharma , Aman Shrivastava , Lubaina Ehsan , Christopher A. Moskaluk , Sana Syed , Donald E. Brown

Whole-slide images (WSI) in computational pathology have high resolution with gigapixel size, but are generally with sparse regions of interest, which leads to weak diagnostic relevance and data inefficiency for each area in the slide. Most…

Computer Vision and Pattern Recognition · Computer Science 2022-12-14 Boxuan Zhao , Jun Zhang , Deheng Ye , Jian Cao , Xiao Han , Qiang Fu , Wei Yang

Digital whole slide images (WSIs) are generally captured at microscopic resolution and encompass extensive spatial data. Directly feeding these images to deep learning models is computationally intractable due to memory constraints, while…

Image and Video Processing · Electrical Eng. & Systems 2024-11-22 Manahil Raza , Ruqayya Awan , Raja Muhammad Saad Bashir , Talha Qaiser , Nasir M. Rajpoot

Global contexts in images are quite valuable in image-to-image translation problems. Conventional attention-based and graph-based models capture the global context to a large extent, however, these are computationally expensive. Moreover,…

Computer Vision and Pattern Recognition · Computer Science 2023-07-13 Ayush Singh , Yash Bhambhu , Himanshu Buckchash , Deepak K. Gupta , Dilip K. Prasad

Reliable whole slide imaging (WSI) hinges on image quality,yet staining artefacts, defocus, and cellular degradations are common. We present DPC-QA Net, a no-reference dual-stream network that couples wavelet-based global difference…

Image and Video Processing · Electrical Eng. & Systems 2025-09-22 Qijun Yang , Boyang Wang , Hujun Yin