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A parameterization strategy for molecular models on the basis of force fields is proposed, which allows a rapid development of models for small molecules by using results from quantum mechanical (QM) ab initio calculations and thermodynamic…

Chemical Physics · Physics 2009-04-22 Bernhard Eckl , Jadran Vrabec , Hans Hasse

Neural network potentials (NNPs) enable large-scale molecular dynamics (MD) simulations of systems containing >10,000 atoms with the accuracy comparable to ab initio methods and play a crucial role in material studies. Although NNPs are…

The plethora of spectra of OB-type stars in observatory archives and the much larger numbers to come from the WEAVE and 4MOST spectroscopic facilities require efficient, but also accurate and precise methods for (semi)automatic quantitative…

Solar and Stellar Astrophysics · Physics 2026-04-06 P. Aschenbrenner , N. Przybilla

This paper explores the internal structure of two quantum mechanics datasets (QM7b, QM9), composed of several thousands of organic molecules and described in terms of electronic properties. Understanding the structure and characteristics of…

Chemical Physics · Physics 2023-09-28 Julio J. Valdés , Alain B. Tchagang

Metal Organic Frameworks (MOFs) are promising materials to help mitigate the effects of global warming by selectively absorbing $\text{CO}_{2}$ for direct capture. Accurate quantum chemistry simulations are a useful tool to help select and…

Chemical accuracy serves as an important metric for assessing the effectiveness of the numerical method in Kohn--Sham density functional theory. It is found that to achieve chemical accuracy, not only the Kohn--Sham wavefunctions but also…

Computational Physics · Physics 2023-10-25 Yang Kuang , Yedan Shen , Guanghui Hu

Atomic-level simulations are widely used to study biomolecules and their dynamics. A common goal in such studies is to compare simulations of a molecular system under several conditions -- for example, with various mutations or bound…

Biomolecules · Quantitative Biology 2025-01-07 Martin Vögele , Neil J. Thomson , Sang T. Truong , Jasper McAvity , Ulrich Zachariae , Ron O. Dror

Small molecules in biological samples are studied to provide information about disease states, environmental toxins, natural product drug discovery, and many other applications. The primary window into the composition of small molecule…

Machine Learning · Computer Science 2023-05-08 Gennady Voronov , Rose Lightheart , Joe Davison , Christoph A. Krettler , David Healey , Thomas Butler

Accurate vibrational spectra are essential for understanding how molecules behave, yet their computation remains challenging and benchmark data to reliably compare different methods are sparse. Here, we present high-accuracy eigenstate…

Chemical Physics · Physics 2025-04-16 Henrik R. Larsson

The demand for safe, high-energy-density batteries has spotlighted halide solid-state electrolytes, which offer the potential for enhanced ionic mobility, electrochemical stability, and interfacial deformability. Accelerating their…

Rapid determination of molecular structures can greatly accelerate workflows across many chemical disciplines. However, elucidating structure using only one-dimensional (1D) NMR spectra, the most readily accessible data, remains an…

Chemical Physics · Physics 2024-08-16 Frank Hu , Michael S. Chen , Grant M. Rotskoff , Matthew W. Kanan , Thomas E. Markland

Simulating chemical dynamics is computationally challenging, especially for nonadiabatic dynamics, where numerically exact classical simulations scale exponentially with system size, becoming intractable for even small molecules. On quantum…

Quantum Physics · Physics 2025-12-25 Henry L. Nourse , Vanessa C. Olaya-Agudelo , Ivan Kassal

Conical intersections play central roles in photoinduced reactions. However, comprehensive conical-intersection datasets that could advance our understanding of excited-state reaction processes remain scarce. To address this gap, we…

Chemical Physics · Physics 2026-05-15 Jiahui Zhang , Yifei Zhu , Chuqiao Feng , Yingjin Ma , Chao Xu , Zhenggang Lan

The QM9 dataset [Scientific Data, Vol. 1, 140022 (2014)] became a standard dataset to benchmark machine learning methods, especially on molecular graphs. It contains geometries as well as multiple computed molecular properties of 133,885…

For over a decade, linear and symmetric weight updates have remained the elusive holy grail in neuromorphic computing. Here, we unveil a kinetically controlled molecular mechanism driving a near-ideal neuromorphic element, capable of…

Emerging Technologies · Computer Science 2025-01-06 Bidyabhusan Kundu , Sreetosh Goswami

Recent advancements in quantum algorithms have reached a state where we can consider how to capitalize on quantum and classical computational resources to accelerate molecular resonance state identification. Here we identify molecular…

Quantum Physics · Physics 2026-03-26 Jingcheng Dai , Atharva Vidwans , Eric H. Wan , Alexander X. Miller , Micheline B. Soley

Quantum computers can be used to calculate the electronic structure and estimate the ground state energy of many-electron molecular systems. In the present study, we implement the Variational Quantum Eigensolver (VQE) algorithm, as a hybrid…

Quantum Physics · Physics 2024-11-11 Hamid Reza Naeij , Erfan Mahmoudi , Hossein Davoodi Yeganeh , Mohsen Akbari

Novel implementations based on dense tensor storage are presented for the singlet-reference perfect quadruples (PQ) [Parkhill, Lawler, and Head-Gordon, J. Chem. Phys. 130, 084101 (2009)] and perfect hextuples (PH) [Parkhill and Head-Gordon,…

Strongly Correlated Electrons · Physics 2016-10-07 Susi Lehtola , John Parkhill , Martin Head-Gordon

The average energy curvature as a function of the particle number is a molecule-specific quantity, which measures the deviation of a given functional from the exact conditions of density functional theory (DFT). Related to the lack of…

Chemical Physics · Physics 2020-11-11 Alberto Fabrizio , Benjamin Meyer , Clemence Corminboeuf
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