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Motivation: The scalable identification of bioactive compounds is essential for contemporary drug discovery. This process faces a key trade-off: structural screening offers scalability but lacks biological context, whereas high-content…

Quantitative Methods · Quantitative Biology 2026-03-17 Xiaoqing Lian , Pengsen Ma , Tengfeng Ma , Zhonghao Ren , Xibao Cai , Zhixiang Cheng , Bosheng Song , He Wang , Xiang Pan , Yangyang Chen , Sisi Yuan , Chen Lin

In the global challenge of understanding and characterizing biodiversity, short species-specific genomic sequences known as DNA barcodes play a critical role, enabling fine-grained comparisons among organisms within the same kingdom of…

Recently we proposed an algorithm for the fast reconstruction of compact context-specific metabolic networks (FASTCORE) that allowed dropping the reconstruction time to the time order of seconds (Vlassis et al.,2014). This extremely low…

Molecular Networks · Quantitative Biology 2014-07-25 Maria Pires Pacheco , Thomas Sauter

Barcodes are used in many commercial applications, thus fast and robust reading is important. There are many different types of barcodes, some of them look similar while others are completely different. In this paper we introduce new fast…

Computer Vision and Pattern Recognition · Computer Science 2020-06-19 Andrey Zharkov , Ivan Zagaynov

Biologically Inspired Design (BID), or Biomimicry, is a problem-solving methodology that applies analogies from nature to solve engineering challenges. For example, Speedo engineers designed swimsuits based on shark skin. Finding relevant…

Computation and Language · Computer Science 2023-12-21 Hen Emuna , Nadav Borenstein , Xin Qian , Hyeonsu Kang , Joel Chan , Aniket Kittur , Dafna Shahaf

We propose Material Fingerprinting, a new method for the rapid discovery of mechanical material models from direct or indirect data that avoids solving potentially non-convex optimization problems. The core assumption of Material…

Computational Engineering, Finance, and Science · Computer Science 2025-12-09 Moritz Flaschel , Denisa Martonová , Carina Veil , Ellen Kuhl

Material Fingerprinting is a lookup table-based strategy to discover material models from experimental measurements, which completely avoids the need to solve an optimization problem. In an offline phase, a comprehensive database of…

Computational Engineering, Finance, and Science · Computer Science 2026-01-22 Moritz Flaschel , Miguel Angel Moreno-Mateos , Simon Wiesheier , Paul Steinmann , Ellen Kuhl

We investigate the concept of deep barcodes and propose two methods to generate them in order to expedite the process of classification and retrieval of histopathology images. Since binary search is computationally less expensive, in terms…

Image and Video Processing · Electrical Eng. & Systems 2018-05-24 Meghana Dinesh Kumar , Morteza Babaie , Hamid Tizhoosh

Products codes (PCs) are conventionally decoded with efficient iterative bounded-distance decoding (iBDD) based on hard-decision channel outputs which entails a performance loss compared to a soft-decision decoder. Recently, several hybrid…

Information Theory · Computer Science 2022-11-22 Sisi Miao , Lukas Rapp , Laurent Schmalen

Object encoding and identification are crucial for many robotic tasks such as autonomous exploration and semantic relocalization. Existing works heavily rely on the tracking of detected objects but have difficulty recalling revisited…

Robotics · Computer Science 2022-01-27 Kuan Xu , Chen Wang , Chao Chen , Wei Wu , Sebastian Scherer

Diagnostic activities, such as ultrasound scans and palpation, are relatively low-cost. They play a crucial role in the early detection of health problems and in assessing their progression. However, they are also error-prone activities,…

Advancing human induced pluripotent stem cell derived cardiomyocyte (hiPSC-CM) technology will lead to significant progress ranging from disease modeling, to drug discovery, to regenerative tissue engineering. Yet, alongside these potential…

For whole-body (WB) kinetic modeling based on a typical PET scanner, a multi-pass multi-bed scanning protocol is necessary given the limited axial field-of-view. Such a protocol introduces loss of early-dynamics in time-activity curves…

Medical Physics · Physics 2024-05-14 Kyung-Nam Lee , Arman Rahmim , Carlos Uribe

Neural prosthetics are typically situated in an aggressive, biochemical environment that requires materials with superior stability and performance. These probes have dual functionalities of recording and stimulation. The material stability…

Applied Physics · Physics 2021-05-14 Nha Uyen Huynh , Sam Kassegne , George Youssef

High-throughput materials synthesis methods have risen in popularity due to their potential to accelerate the design and discovery of novel functional materials, such as solution-processed semiconductors. After synthesis, key material…

Image and Video Processing · Electrical Eng. & Systems 2024-06-17 Alexander E. Siemenn , Eunice Aissi , Fang Sheng , Armi Tiihonen , Hamide Kavak , Basita Das , Tonio Buonassisi

Product codes (PCs) and staircase codes (SCCs) are conventionally decoded based on bounded distance decoding (BDD) of the component codes and iterating between row and column decoders. The performance of iterative BDD (iBDD) can be improved…

Information Theory · Computer Science 2021-09-08 Alireza Sheikh , Alexandre Graell i Amat , Alex Alvarado

The transport of bio-particles in viscous flows exhibits a rich variety of dynamical behaviour, such as morphological transitions, complex orientation dynamics or deformations. Characterising such complex behaviour under well controlled…

Harnessing the rich nonlinear dynamics of highly-deformable materials has the potential to unlock the next generation of functional smart materials and devices. However, unlocking such potential requires effective strategies to spatially…

Microstructure of materials is often characterized through image analysis to understand processing-structure-properties linkages. We propose a largely automated framework that integrates unsupervised and supervised learning methods to…

Applications · Statistics 2025-09-05 Kungang Zhang , Wei Chen , Wing K. Liu , L. Catherine Brinson , Daniel W. Apley

In this study, we propose a novel microstructure-sensitive Bayesian optimization (BO) framework designed to enhance the efficiency of materials discovery by explicitly incorporating microstructural information. Traditional materials design…

Materials Science · Physics 2025-02-07 Danial Khatamsaz , Vahid Attari , Raymundo Arroyave
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