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Understanding how neural networks process complex patterns of information is crucial for advancing both neuroscience and artificial intelligence. To investigate fundamental principles of neural computation, we studied dissociated neuronal…

Neurons and Cognition · Quantitative Biology 2025-03-03 Zhuo Zhang , Amit Yaron , Dai Akita , Tomoyo Isoguchi Shiramatsu , Zenas C. Chao , Hirokazu Takahashi

In vitro primary cultures of dissociated invertebrate neurons from locust ganglia are used to experimentally investigate the morphological evolution of assemblies of living neurons, as they self-organize from collections of separated cells…

Adaptation and Self-Organizing Systems · Physics 2014-02-14 Daniel de Santos-Sierra , Irene Sendiña-Nadal , Inmaculada Leyva , Juan A. Almendral , Sarit Anava , Amir Ayali , David Papo , Stefano Boccaletti

A powerful experimental approach for investigating computation in networks of biological neurons is the use of cultured dissociated cortical cells grown into networks on a multi-electrode array. Such preparations allow investigation of…

Neurons and Cognition · Quantitative Biology 2008-05-23 M. Stiber , F. Kawasaki , D. Xu

Living neuronal networks in dissociated neuronal cultures are widely known for their ability to generate highly robust spatiotemporal activity patterns in various experimental conditions. These include neuronal avalanches satisfying the…

Adaptation and Self-Organizing Systems · Physics 2022-05-17 I. Y. Tyukin , D. Iudin , F. Iudin , T. Tyukina , V. Kazantsev , I. Mukhina , A. N. Gorban

Previous work has shown that it is possible to train neuronal cultures on Multi-Electrode Arrays (MEAs), to recognize very simple patterns. However, this work was mainly focused to demonstrate that it is possible to induce plasticity in…

Computer Vision and Pattern Recognition · Computer Science 2021-01-25 Gabriele Lagani , Raffaele Mazziotti , Fabrizio Falchi , Claudio Gennaro , Guido Marco Cicchini , Tommaso Pizzorusso , Federico Cremisi , Giuseppe Amato

The analysis of the activity of neuronal cultures is considered to be a good proxy of the functional connectivity of in vivo neuronal tissues. Thus, the functional complex network inferred from activity patterns is a promising way to…

Neurons and Cognition · Quantitative Biology 2014-09-09 Sara Teller , Clara Granell , Manlio De Domenico , Jordi Soriano , Sergio Gomez , Alex Arenas

In modern deep neural networks, the learning dynamics of the individual neurons is often obscure, as the networks are trained via global optimization. Conversely, biological systems build on self-organized, local learning, achieving…

Recent advances at the intersection of control theory, neuroscience, and machine learning have revealed novel mechanisms by which dynamical systems perform computation. These advances encompass a wide range of conceptual, mathematical, and…

Machine Learning · Computer Science 2026-04-10 Arthur N. Montanari , Francesco Bullo , Dmitry Krotov , Adilson E. Motter

Living neural networks emerge through a process of growth and self-organization that begins with a single cell and results in a brain, an organized and functional computational device. Artificial neural networks, however, rely on…

Neural and Evolutionary Computing · Computer Science 2019-06-05 Guruprasad Raghavan , Matt Thomson

Artificial neural networks which are inspired from the learning mechanism of brain have achieved great successes in many problems, especially those with deep layers. In this paper, we propose a nucleus neural network (NNN) and corresponding…

Computer Vision and Pattern Recognition · Computer Science 2019-05-15 Jia Liu , Maoguo Gong , Haibo He

Neuronal systems need to process temporal signals. We here show how higher-order temporal (co-)fluctuations can be employed to represent and process information. Concretely, we demonstrate that a simple biologically inspired feedforward…

Neurons and Cognition · Quantitative Biology 2023-09-13 Sandra Nestler , Moritz Helias , Matthieu Gilson

Language and culture are deeply intertwined, yet it has been unclear how and where multilingual large language models encode culture. Here, we build on an established methodology for identifying language-specific neurons to localize and…

Computation and Language · Computer Science 2025-11-12 Danial Namazifard , Lukas Galke Poech

Randomized Neural Networks explore the behavior of neural systems where the majority of connections are fixed, either in a stochastic or a deterministic fashion. Typical examples of such systems consist of multi-layered neural network…

Machine Learning · Computer Science 2021-02-03 Claudio Gallicchio , Simone Scardapane

The brain can efficiently learn a wide range of tasks, motivating the search for biologically inspired learning rules for improving current artificial intelligence technology. Most biological models are composed of point neurons, and cannot…

Neurons and Cognition · Quantitative Biology 2026-04-13 Cristiano Capone , Cosimo Lupo , Paolo Muratore , Pier Stanislao Paolucci

Improvements in technique in conjunction with an evolution of the theoretical and conceptual approach to neuronal networks provide a new perspective on living neurons in culture. Organization and connectivity are being measured…

Disordered Systems and Neural Networks · Physics 2010-08-02 Jean-Pierre Eckmann , Ofer Feinerman , Leor Gruendlinger , Elisha Moses , Jordi Soriano , Tsvi Tlusty

Neurons with internal memory have been proposed for biological and bio-inspired neural networks, adding interesting functionality. We propose and model a nanoscale optoelectronic neural node with charge-based time-limited memory and signal…

Applied Physics · Physics 2023-09-22 David Winge , Magnus Borgström , Erik Lind , Anders Mikkelsen

The neural mechanism of memory has a very close relation with the problem of representation in artificial intelligence. In this paper a computational model was proposed to simulate the network of neurons in brain and how they process…

Neurons and Cognition · Quantitative Biology 2020-12-02 Hui Wei

The complex and unique neural network topology of the human brain formed through natural evolution enables it to perform multiple cognitive functions simultaneously. Automated evolutionary mechanisms of biological network structure inspire…

Neural and Evolutionary Computing · Computer Science 2023-09-12 Wenxuan Pan , Feifei Zhao , Zhuoya Zhao , Yi Zeng

First-principles-based modelings have been extremely successful in providing crucial insights and predictions for complex biological functions and phenomena. However, they can be hard to build and expensive to simulate for complex living…

Adaptation and Self-Organizing Systems · Physics 2024-11-26 Ruilin Zhang , Zhongyi Wang , Tianyi Wu , Yuhang Cai , Louis Tao , Zhuo-Cheng Xiao , Yao Li

Neurons in the brain are often finely tuned for specific task variables. Moreover, such disentangled representations are highly sought after in machine learning. Here we mathematically prove that simple biological constraints on neurons,…

Neurons and Cognition · Quantitative Biology 2023-04-04 James C. R. Whittington , Will Dorrell , Surya Ganguli , Timothy E. J. Behrens
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