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Electronic health records (EHRs) are long, noisy, and often redundant, posing a major challenge for the clinicians who must navigate them. Large language models (LLMs) offer a promising solution for extracting and reasoning over this…

Computation and Language · Computer Science 2025-08-21 Skatje Myers , Dmitriy Dligach , Timothy A. Miller , Samantha Barr , Yanjun Gao , Matthew Churpek , Anoop Mayampurath , Majid Afshar

Objective: Large language models (LLMs) are attracting increasing interest in healthcare. This commentary evaluates the potential of LLMs to improve clinical prediction models (CPMs) for diagnostic and prognostic tasks, with a focus on…

Computers and Society · Computer Science 2025-11-07 Yusuf Yildiz , Goran Nenadic , Meghna Jani , David A. Jenkins

This study is the first to investigate LLM comprehension capabilities over long-context (LC), clinically relevant medical Question Answering (QA) beyond MCQA. Our comprehensive approach considers a range of settings based on content…

Computation and Language · Computer Science 2026-01-16 Feras AlMannaa , Talia Tseriotou , Jenny Chim , Maria Liakata

Electronic Health Records (EHRs) provide rich longitudinal clinical evidence that is central to medical decision-making, motivating the use of retrieval-augmented generation (RAG) to ground large language model (LLM) predictions. However,…

Artificial Intelligence · Computer Science 2026-01-30 Lang Cao , Qingyu Chen , Yue Guo

The proliferation of Large Language Models (LLMs) in medicine has enabled impressive capabilities, yet a critical gap remains in their ability to perform systematic, transparent, and verifiable reasoning, a cornerstone of clinical practice.…

Computation and Language · Computer Science 2025-08-04 Wenxuan Wang , Zizhan Ma , Meidan Ding , Shiyi Zheng , Shengyuan Liu , Jie Liu , Jiaming Ji , Wenting Chen , Xiang Li , Linlin Shen , Yixuan Yuan

Analyzing vast textual data and summarizing key information from electronic health records imposes a substantial burden on how clinicians allocate their time. Although large language models (LLMs) have shown promise in natural language…

This study applies Large Language Models (LLMs) to two foundational Electronic Health Record (EHR) data science tasks: structured data querying (using programmatic languages, Python/Pandas) and information extraction from unstructured…

Computation and Language · Computer Science 2026-01-29 Juan Jose Rubio Jan , Jack Wu , Julia Ive

While large language models (LLMs) have demonstrated remarkable reasoning capabilities, they are not without their flaws and inaccuracies. Recent studies have introduced various methods to mitigate these limitations. Temporal reasoning…

Computation and Language · Computer Science 2024-10-10 Siheng Xiong , Ali Payani , Ramana Kompella , Faramarz Fekri

The rapid increase in textual information means we need more efficient methods to sift through, organize, and understand it all. While retrieval-augmented generation (RAG) models excel in accessing information from large document…

Computation and Language · Computer Science 2025-03-14 Seiji Maekawa , Hayate Iso , Nikita Bhutani

The integration of multimodal Electronic Health Records (EHR) data has significantly improved clinical predictive capabilities. Leveraging clinical notes and multivariate time-series EHR, existing models often lack the medical context…

Artificial Intelligence · Computer Science 2024-02-13 Yinghao Zhu , Changyu Ren , Shiyun Xie , Shukai Liu , Hangyuan Ji , Zixiang Wang , Tao Sun , Long He , Zhoujun Li , Xi Zhu , Chengwei Pan

Improving large language models (LLMs) for electronic health record (EHR) reasoning is essential for enabling accurate and generalizable clinical predictions. While LLMs excel at medical text understanding, they underperform on EHR-based…

Artificial Intelligence · Computer Science 2025-08-20 Yue Fang , Yuxin Guo , Jiaran Gao , Hongxin Ding , Xinke Jiang , Weibin Liao , Yongxin Xu , Yinghao Zhu , Zhibang Yang , Liantao Ma , Junfeng Zhao , Yasha Wang

Large language models (LLMs) have emerged as promising tools for assisting in medical tasks, yet processing Electronic Health Records (EHRs) presents unique challenges due to their longitudinal nature. While LLMs' capabilities to perform…

Artificial Intelligence · Computer Science 2025-03-07 Hejie Cui , Alyssa Unell , Bowen Chen , Jason Alan Fries , Emily Alsentzer , Sanmi Koyejo , Nigam Shah

Retrieval Augmented Generation (RAG) has emerged as a crucial technique for enhancing the accuracy of Large Language Models (LLMs) by incorporating external information. With the advent of LLMs that support increasingly longer context…

Machine Learning · Computer Science 2024-11-07 Quinn Leng , Jacob Portes , Sam Havens , Matei Zaharia , Michael Carbin

This paper describes an investigation of the robustness of large language models (LLMs) for retrieval augmented generation (RAG)-based summarization tasks. While LLMs provide summarization capabilities, their performance in complex,…

Computation and Language · Computer Science 2024-04-01 Shengjie Liu , Jing Wu , Jingyuan Bao , Wenyi Wang , Naira Hovakimyan , Christopher G Healey

Large Language Models (LLMs) have demonstrated impressive capabilities in reasoning and prediction across different domains. Yet, their ability to infer temporal regularities from structured behavioral data remains underexplored. This paper…

Large language models (LLMs) are increasingly being applied to clinical care, a domain where both accuracy and transparent reasoning are critical for safe and trustworthy deployment. Chain-of-thought (CoT) prompting, which elicits…

Computation and Language · Computer Science 2025-12-09 Jiageng Wu , Kevin Xie , Bowen Gu , Nils Krüger , Kueiyu Joshua Lin , Jie Yang

Large Language Models (LLMs) have shown strong promise for mining Electronic Health Records (EHRs) by reasoning over longitudinal clinical information to capture context-rich patient trajectories. However, leveraging LLMs for structured…

Computation and Language · Computer Science 2026-04-21 Arya Hadizadeh Moghaddam , Drew Ross , Mohsen Nayebi Kerdabadi , Dongjie Wang , Zijun Yao

This paper explores whether enhancing temporal reasoning capabilities in Large Language Models (LLMs) can improve the quality of timeline summarisation, the task of summarising long texts containing sequences of events, such as social media…

Computation and Language · Computer Science 2025-07-21 Jiayu Song , Mahmud Elahi Akhter , Dana Atzil Slonim , Maria Liakata

The increasing complexity of clinical decision-making, alongside the rapid expansion of electronic health records (EHR), presents both opportunities and challenges for delivering data-informed care. This paper proposes a clinical decision…

Artificial Intelligence · Computer Science 2025-10-03 Leon Garza , Anantaa Kotal , Michael A. Grasso , Emre Umucu

Large language models (LLMs) have shown promise in medical question answering but often struggle with hallucinations and shallow reasoning, particularly in tasks requiring nuanced clinical understanding. Retrieval-augmented generation (RAG)…

Computation and Language · Computer Science 2025-08-25 Ziyu Wang , Elahe Khatibi , Amir M. Rahmani
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