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Physiologically Based Pharmacokinetic (PBPK) modeling is a cornerstone of model-informed drug development (MIDD), providing a mechanistic framework to predict drug absorption, distribution, metabolism, and excretion (ADME). Despite its…

Machine Learning · Computer Science 2026-02-24 Shunqi Liu , Han Qiu , Tong Wang

Advancements in scientific instrument sensors and connected devices provide unprecedented insight into ongoing experiments and present new opportunities for control, optimization, and steering. However, the diversity of sensors and…

Distributed, Parallel, and Cluster Computing · Computer Science 2022-05-04 Jakob R. Elias , Ryan Chard , Maksim Levental , Zhengchun Liu , Ian Foster , Santanu Chaudhuri

We are delighted to see the recent development of physics-informed extreme learning machine (PIELM) for its higher computational efficiency and accuracy compared to other physics-informed machine learning (PIML) paradigms. Since a…

Machine Learning · Computer Science 2025-11-04 He Yang , Fei Ren , Francesco Calabro , Hai-Sui Yu , Xiaohui Chen , Pei-Zhi Zhuang

Modeling thermal states for complex space missions, such as the surface exploration of airless bodies, requires high computation, whether used in ground-based analysis for spacecraft design or during onboard reasoning for autonomous…

Machine Learning · Computer Science 2024-09-06 Manaswin Oddiraju , Zaki Hasnain , Saptarshi Bandyopadhyay , Eric Sunada , Souma Chowdhury

Current modeling approaches for hydrological modeling often rely on either physics-based or data-science methods, including Machine Learning (ML) algorithms. While physics-based models tend to rigid structure resulting in unrealistic…

Machine Learning · Statistics 2021-04-23 Pravin Bhasme , Jenil Vagadiya , Udit Bhatia

In the context of science, the well-known adage "a picture is worth a thousand words" might well be "a model is worth a thousand datasets." In this manuscript we introduce the SciML software ecosystem as a tool for mixing the information of…

Machine learning has been increasingly applied in climate modeling on system emulation acceleration, data-driven parameter inference, forecasting, and knowledge discovery, addressing challenges such as physical consistency, multi-scale…

Scientific Machine Learning (SciML) has advanced recently across many different areas in computational science and engineering. The objective is to integrate data and physics seamlessly without the need of employing elaborate and…

Machine Learning · Computer Science 2023-08-02 Varun Kumar , Leonard Gleyzer , Adar Kahana , Khemraj Shukla , George Em Karniadakis

Scientific machine learning (SciML) represents a significant advancement in integrating machine learning (ML) with scientific methodologies. At the forefront of this development are Physics-Informed Neural Networks (PINNs), which offer a…

Machine Learning · Computer Science 2024-11-19 Reyhaneh Taj

Musculoskeletal models have been widely used for detailed biomechanical analysis to characterise various functional impairments given their ability to estimate movement variables (i.e., muscle forces and joint moment) which cannot be…

Signal Processing · Electrical Eng. & Systems 2022-07-05 Jie Zhang , Yihui Zhao , Fergus Shone , Zhenhong Li , Alejandro F. Frangi , Shengquan Xie , Zhiqiang Zhang

Traditional rule-based physical models are limited by their reliance on singular physical formulas and parameters, making it difficult to effectively tackle the intricate tasks associated with crowd simulation. Recent research has…

Artificial Intelligence · Computer Science 2024-10-22 Runkang Guo , Bin Chen , Qi Zhang , Yong Zhao , Xiao Wang , Zhengqiu Zhu

Science-based simulation tools such as Finite Element (FE) models are routinely used in scientific and engineering applications. While their success is strongly dependent on our understanding of underlying governing physical laws, they…

Machine Learning · Computer Science 2021-03-31 Navid Zobeiry , Anoush Poursartip

Training sophisticated machine learning (ML) models requires large datasets that are difficult or expensive to collect for many applications. If prior knowledge about system dynamics is available, mechanistic representations can be used to…

Geosystems are geological formations altered by humans activities such as fossil energy exploration, waste disposal, geologic carbon sequestration, and renewable energy generation. Geosystems also represent a critical link in the global…

Geophysics · Physics 2021-04-14 Alexander Y. Sun , Hongkyu Yoon , Chung-Yan Shih , Zhi Zhong

The physics-based modeling has been the workhorse for many decades in many scientific and engineering applications ranging from wind power, weather forecasting, and aircraft design. Recently, data-driven models are increasingly becoming…

Computational Physics · Physics 2021-01-18 Suraj Pawar , Shady E. Ahmed , Omer San , Adil Rasheed

Quantifying and propagating modeling uncertainties is crucial for reliability analysis, robust optimization, and other model-based algorithmic processes in engineering design and control. Now, physics-informed machine learning (PIML)…

Machine Learning · Computer Science 2025-07-14 Manaswin Oddiraju , Bharath Varma Penumatsa , Divyang Amin , Michael Piedmonte , Souma Chowdhury

This paper proposes a cutting mechanics-based machine learning (CMML) modeling method to discover governing equations of machining dynamics. The main idea of CMML design is to integrate existing physics in cutting mechanics and unknown…

Machine Learning · Computer Science 2026-01-06 Alisa Ren , Mason Ma , Jiajie Wu , Jaydeep Karandikar , Chris Tyler , Tony Shi , Tony Schmitz

To learn about real world phenomena, scientists have traditionally used models with clearly interpretable elements. However, modern machine learning (ML) models, while powerful predictors, lack this direct elementwise interpretability (e.g.…

Machine Learning · Statistics 2024-07-16 Timo Freiesleben , Gunnar König , Christoph Molnar , Alvaro Tejero-Cantero

This paper presents an overview of scientific modeling and discusses the complementary strengths and weaknesses of ML methods for scientific modeling in comparison to process-based models. It also provides an introduction to the current…

Machine Learning · Computer Science 2024-05-03 Anuj Karpatne , Xiaowei Jia , Vipin Kumar

Causal machine learning (CML) has experienced increasing popularity in healthcare. Beyond the inherent capabilities of adding domain knowledge into learning systems, CML provides a complete toolset for investigating how a system would react…

Machine Learning · Computer Science 2022-06-01 Pedro Sanchez , Jeremy P. Voisey , Tian Xia , Hannah I. Watson , Alison Q. ONeil , Sotirios A. Tsaftaris