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It is well known that tumors originating from the same tissue have different prognosis and sensitivity to treatments. Over the last decade, cancer genomics consortia like the Cancer Genome Atlas (TCGA) have been generating thousands of…

Root-mean-square deviation (RMSD) is widely used to assess structural similarity in systems ranging from flexible ligand conformers to complex molecular cluster configurations. Despite its wide utility, RMSD calculation is often challenged…

Biomolecules · Quantitative Biology 2025-09-03 Xiaoqi Wei , Xuhang Dai , Yaqi Wu , Yanxiang Zhao , Yingkai Zhang , Zixuan Cang

Multi-label image classification is a prediction task that aims to identify more than one label from a given image. This paper considers the semantic consistency of the latent space between the visual patch and linguistic label domains and…

Computer Vision and Pattern Recognition · Computer Science 2023-08-21 Miaoge Li , Dongsheng Wang , Xinyang Liu , Zequn Zeng , Ruiying Lu , Bo Chen , Mingyuan Zhou

Dataset distillation seeks to synthesize a compact distilled dataset, enabling models trained on it to achieve performance comparable to models trained on the full dataset. Recent methods for large-scale datasets focus on matching global…

Computer Vision and Pattern Recognition · Computer Science 2025-12-02 Xiao Cui , Yulei Qin , Wengang Zhou , Hongsheng Li , Houqiang Li

Co-clustering targets on grouping the samples (e.g., documents, users) and the features (e.g., words, ratings) simultaneously. It employs the dual relation and the bilateral information between the samples and features. In many realworld…

Machine Learning · Computer Science 2016-11-18 Ping Li , Jiajun Bu , Chun Chen , Zhanying He , Deng Cai

In online clustering problems, there is often a large amount of uncertainty over possible cluster assignments that cannot be resolved until more data are observed. This difficulty is compounded when clusters follow complex distributions, as…

Machine Learning · Statistics 2026-04-17 Connie Trojan , Pavel Myshkov , Paul Fearnhead , James Hensman , Tom Minka , Christopher Nemeth

Identification of disease subtypes and corresponding biomarkers can substantially improve clinical diagnosis and treatment selection. Discovering these subtypes in noisy, high dimensional biomedical data is often impossible for humans and…

Quantitative Methods · Quantitative Biology 2020-05-18 Marc-Andre Schulz , Matt Chapman-Rounds , Manisha Verma , Danilo Bzdok , Konstantinos Georgatzis

Many fields, such as neuroscience, are experiencing the vast proliferation of cellular data, underscoring the need for organizing and interpreting large datasets. A popular approach partitions data into manageable subsets via hierarchical…

Quantitative Methods · Quantitative Biology 2024-03-07 Diek W. Wheeler , Giorgio A. Ascoli

Cell type annotation is a key task in analyzing the heterogeneity of single-cell RNA sequencing data. Although recent foundation models automate this process, they typically annotate cells independently, without considering batch-level…

Computation and Language · Computer Science 2025-06-04 Yin Fang , Qiao Jin , Guangzhi Xiong , Bowen Jin , Xianrui Zhong , Siru Ouyang , Aidong Zhang , Jiawei Han , Zhiyong Lu

Clustering is a technique for the analysis of datasets obtained by empirical studies in several disciplines with a major application for biomedical research. Essentially, clustering algorithms are executed by machines aiming at finding…

Quantitative Methods · Quantitative Biology 2024-09-30 Diego Ulisse Pizzagalli , Santiago Fernandez Gonzalez , Rolf Krause

This thesis examines self-attention training through the lens of Optimal Transport (OT) and develops an OT-based alternative for tabular classification. The study tracks intermediate projections of the self-attention layer during training…

Machine Learning · Statistics 2026-02-19 Alessandro Quadrio , Antonio Candelieri

Hierarchical Extreme Multi-Label Classification poses greater difficulties compared to traditional multi-label classification because of the intricate hierarchical connections of labels within a domain-specific taxonomy and the substantial…

Machine Learning · Computer Science 2025-05-08 Linqing Chen , Weilei Wang , Wentao Wu , Hanmeng Zhong

Document clustering and topic modeling are two closely related tasks which can mutually benefit each other. Topic modeling can project documents into a topic space which facilitates effective document clustering. Cluster labels discovered…

Machine Learning · Computer Science 2013-09-27 Pengtao Xie , Eric P. Xing

Anchor-based multi-view clustering (MVC) has received extensive attention due to its efficient performance. Existing methods only focus on how to dynamically learn anchors from the original data and simultaneously construct anchor graphs…

Computer Vision and Pattern Recognition · Computer Science 2024-12-24 Yawei Chen , Huibing Wang , Jinjia Peng , Yang Wang

The objective of clustering is to discover natural groups in datasets and to identify geometrical structures which might reside there, without assuming any prior knowledge on the characteristics of the data. The problem can be seen as…

Computational Geometry · Computer Science 2018-01-26 Luis-Evaristo Caraballo , José-Miguel Díaz-Báñez , Nadine Kroher

Joint analysis of multi-omic single-cell data across cohorts has significantly enhanced the comprehensive analysis of cellular processes. However, most of the existing approaches for this purpose require access to samples with complete…

Machine Learning · Computer Science 2024-05-21 Marianne Arriola , Weishen Pan , Manqi Zhou , Qiannan Zhang , Chang Su , Fei Wang

In recent years the importance of finding a meaningful pattern from huge datasets has become more challenging. Data miners try to adopt innovative methods to face this problem by applying feature selection methods. In this paper we propose…

Machine Learning · Computer Science 2014-03-11 Mehdi Naseriparsa , Amir-masoud Bidgoli , Touraj Varaee

Scientific literature is expanding at an unprecedented pace, making it increasingly challenging to efficiently organize and access domain knowledge. A high-quality scientific taxonomy offers a structured and hierarchical representation of a…

Computation and Language · Computer Science 2026-05-04 Shiqiang Cai , Nianhong Niu , Shizhu He , Kang Liu , Jun Zhao

This paper investigates the computational and statistical limits in clustering matrix-valued observations. We propose a low-rank mixture model (LrMM), adapted from the classical Gaussian mixture model (GMM) to treat matrix-valued…

Statistics Theory · Mathematics 2023-06-08 Zhongyuan Lyu , Dong Xia

There is a growing need for unbiased clustering methods, ideally automated. We have developed a topology-based analysis tool called Two-Tier Mapper (TTMap) to detect subgroups in global gene expression datasets and identify their…

Genomics · Quantitative Biology 2018-01-08 Rachel Jeitziner , Mathieu Carrière , Jacques Rougemont , Steve Oudot , Kathryn Hess , Cathrin Brisken