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A coarse-grained computational procedure based on the Finite Element Method is proposed to calculate the normal modes and mechanical response of proteins and their supramolecular assemblies. Motivated by the elastic network model, proteins…

Biomolecules · Quantitative Biology 2007-05-23 Mark Bathe

We present EB-JEPA, an open-source library for learning representations and world models using Joint-Embedding Predictive Architectures (JEPAs). JEPAs learn to predict in representation space rather than pixel space, avoiding the pitfalls…

Computer Vision and Pattern Recognition · Computer Science 2026-04-09 Basile Terver , Randall Balestriero , Megi Dervishi , David Fan , Quentin Garrido , Tushar Nagarajan , Koustuv Sinha , Wancong Zhang , Mike Rabbat , Yann LeCun , Amir Bar

Proteins, essential to biological systems, perform functions intricately linked to their three-dimensional structures. Understanding the relationship between protein structures and their amino acid sequences remains a core challenge in…

Quantitative Methods · Quantitative Biology 2024-11-04 Liang He , Peiran Jin , Yaosen Min , Shufang Xie , Lijun Wu , Tao Qin , Xiaozhuan Liang , Kaiyuan Gao , Yuliang Jiang , Tie-Yan Liu

Most biological processes are described as a series of interactions between proteins and other molecules, and interactions are in turn described in terms of atomic structures. To annotate protein functions as sets of interaction states at…

Biomolecules · Quantitative Biology 2012-02-13 Akira R. Kinjo , Haruki Nakamura

A new unified video analytics framework (ER3) is proposed for complex event retrieval, recognition and recounting, based on the proposed video imprint representation, which exploits temporal correlations among image features across video…

Computer Vision and Pattern Recognition · Computer Science 2021-06-08 Zhanning Gao , Le Wang , Nebojsa Jojic , Zhenxing Niu , Nanning Zheng , Gang Hua

In recent years, self-supervised learning has emerged as a powerful tool to harness abundant unlabelled data for representation learning and has been broadly adopted in diverse areas. However, when applied to molecular representation…

Machine Learning · Computer Science 2024-02-22 Han Tang , Shikun Feng , Bicheng Lin , Yuyan Ni , JIngjing Liu , Wei-Ying Ma , Yanyan Lan

Molecular Dynamics (MD) simulations are essential for understanding the atomic-level behavior of molecular systems, giving insights into their transitions and interactions. However, classical MD techniques are limited by the trade-off…

Biomolecules · Quantitative Biology 2026-04-21 Ziyang Yu , Wenbing Huang , Yang Liu

Motivation: Protein interactions are fundamental building blocks of biochemical reaction systems underlying cellular functions. The complexity and functionality of such systems emerge not from the protein interactions themselves but from…

Molecular Networks · Quantitative Biology 2011-06-15 Johannes Köster , Eli Zamir , Sven Rahmann

Molecular representation learning is the first yet vital step in combining deep learning and molecular science. To push the boundaries of molecular representation learning, we present PhysChem, a novel neural architecture that learns…

Quantitative Methods · Quantitative Biology 2021-12-10 Shuwen Yang , Ziyao Li , Guojie Song , Lingsheng Cai

Modern single-cell flow and mass cytometry technologies measure the expression of several proteins of the individual cells within a blood or tissue sample. Each profiled biological sample is thus represented by a set of hundreds of…

Machine Learning · Computer Science 2022-06-29 Siyuan Shan , Vishal Baskaran , Haidong Yi , Jolene Ranek , Natalie Stanley , Junier Oliva

In this paper, we propose EventBind, a novel and effective framework that unleashes the potential of vision-language models (VLMs) for event-based recognition to compensate for the lack of large-scale event-based datasets. In particular,…

Computer Vision and Pattern Recognition · Computer Science 2024-07-25 Jiazhou Zhou , Xu Zheng , Yuanhuiyi Lyu , Lin Wang

Model merging aims to integrate multiple task-specific fine-tuned models derived from a shared pre-trained checkpoint into a single multi-task model without additional training. Despite extensive research, task interference remains a major…

Machine Learning · Computer Science 2026-02-25 Longhua Li , Lei Qi , Qi Tian , Xin Geng

Recent recommender systems increasingly leverage embeddings from large pre-trained language models (PLMs). However, such embeddings exhibit two key limitations: (1) PLMs are not explicitly optimized to produce structured and discriminative…

Computation and Language · Computer Science 2026-01-19 Guy Hadad , Neomi Rabaev , Bracha Shapira

Developing accurate models for chemical reactors is often challenging due to the complexity of reaction kinetics and process dynamics. Traditional approaches require retraining models for each new system, limiting generalizability and…

Computational Engineering, Finance, and Science · Computer Science 2025-05-29 Zihao Wang , Zhe Wu

Word embeddings have been shown adept at capturing the semantic and syntactic regularities of the natural language text, as a result of which these representations have found their utility in a wide variety of downstream content analysis…

Computation and Language · Computer Science 2021-03-02 Kishlay Jha

Machine learning has recently emerged as a powerful tool for generating new molecular and material structures. The success of state-of-the-art models stems from their ability to incorporate physical symmetries, such as translation,…

Machine Learning · Computer Science 2024-05-16 Bingqing Cheng

Processes involving multi-input multi-step reaction cascades are used in developing novel biosensing, biocomputing, and decision making systems. In various applications different changes in responses of the constituent processing steps…

Molecular Networks · Quantitative Biology 2016-08-16 Sergii Domanskyi , Vladimir Privman

Biological networks provide insight into the complex organization of biological processes in a cell at the system level. They are an effective tool for understanding the comprehensive map of functional interactions, finding the functional…

Molecular Networks · Quantitative Biology 2017-09-14 Somaye Hashemifar

The recent advances in neural language models have also been successfully applied to the field of chemistry, offering generative solutions for classical problems in molecular design and synthesis planning. These new methods have the…

Machine Learning · Computer Science 2023-05-19 Dimitrios Christofidellis , Giorgio Giannone , Jannis Born , Ole Winther , Teodoro Laino , Matteo Manica

Objects and their relationships are critical contents for image understanding. A scene graph provides a structured description that captures these properties of an image. However, reasoning about the relationships between objects is very…

Computer Vision and Pattern Recognition · Computer Science 2018-11-16 Sanghyun Woo , Dahun Kim , Donghyeon Cho , In So Kweon