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Melanoma detection is vital for early diagnosis and effective treatment. While deep learning models on dermoscopic images have shown promise, they require specialized equipment, limiting their use in broader clinical settings. This study…

Computer Vision and Pattern Recognition · Computer Science 2026-05-20 Volodymyr Sydorskyi , Igor Krashenyi , Oleksii Yakubenko

The use of machine learning (ML) for cancer staging through medical image analysis has gained substantial interest across medical disciplines. When accompanied by the innovative federated learning (FL) framework, ML techniques can further…

Machine Learning · Computer Science 2024-10-10 Kasra Borazjani , Naji Khosravan , Leslie Ying , Seyyedali Hosseinalipour

Healthcare applications are inherently multimodal, benefiting greatly from the integration of diverse data sources. However, the modalities available in clinical settings can vary across different locations and patients. A key area that…

Computer Vision and Pattern Recognition · Computer Science 2025-09-04 Mohammed Amer , Mohamed A. Suliman , Tu Bui , Nuria Garcia , Serban Georgescu

Multimodal approaches that integrate histology and genomics hold strong potential for precision oncology. However, phenotypic and genotypic heterogeneity limits the quality of intra-modal representations and hinders effective inter-modal…

Computer Vision and Pattern Recognition · Computer Science 2025-12-01 Yupei Zhang , Yating Huang , Wanming Hu , Lequan Yu , Hujun Yin , Chao Li

The application of machine learning in medicine and healthcare has led to the creation of numerous diagnostic and prognostic models. However, despite their success, current approaches generally issue predictions using data from a single…

Machine Learning · Computer Science 2025-05-13 Fergus Imrie , Stefan Denner , Lucas S. Brunschwig , Klaus Maier-Hein , Mihaela van der Schaar

Cancer survival prediction from multi-omics data remains challenging because prognostic signals are high-dimensional, heterogeneous, and distributed across interacting genes and pathways. We propose PathMoG, a pathway-centric modular graph…

Machine Learning · Computer Science 2026-04-28 Di Wang , Chupei Tang , Junxiao Kong , Jixiu Zhai , Moyu Tang , Tianchi Lu

Multimodal machine learning integrating histopathology and molecular data shows promise for cancer prognostication. We systematically reviewed studies combining whole slide images (WSIs) and high-throughput omics to predict overall…

Quantitative Methods · Quantitative Biology 2025-07-30 Charlotte Jennings , Andrew Broad , Lucy Godson , Emily Clarke , David Westhead , Darren Treanor

Oral cancer is frequently diagnosed at later stages due to its similarity to other lesions. Existing research on computer aided diagnosis has made progress using deep learning; however, most approaches remain limited by small, imbalanced…

Computer Vision and Pattern Recognition · Computer Science 2026-01-06 Joy Naoum , Revana Salama , Ali Hamdi

Survival analysis plays a vital role in making clinical decisions. However, the models currently in use are often difficult to interpret, which reduces their usefulness in clinical settings. Prototype learning presents a potential solution,…

Computer Vision and Pattern Recognition · Computer Science 2025-10-08 Shuo Jiang , Zhuwen Chen , Liaoman Xu , Yanming Zhu , Changmiao Wang , Jiong Zhang , Feiwei Qin , Yifei Chen , Zhu Zhu

Machine learning methods in healthcare have traditionally focused on using data from a single modality, limiting their ability to effectively replicate the clinical practice of integrating multiple sources of information for improved…

Machine Learning · Computer Science 2024-02-13 Felix Krones , Umar Marikkar , Guy Parsons , Adam Szmul , Adam Mahdi

In a complex disease such as tuberculosis, the evidence for the disease and its evolution may be present in multiple modalities such as clinical, genomic, or imaging data. Effective patient-tailored outcome prediction and therapeutic…

Accurate survival prediction in oncology requires integrating diverse imaging modalities to capture the complex interplay of tumor biology. Traditional single-modality approaches often fail to leverage the complementary insights provided by…

Computer Vision and Pattern Recognition · Computer Science 2025-03-14 Ho Hin Lee , Alberto Santamaria-Pang , Jameson Merkov , Matthew Lungren , Ivan Tarapov

Histopathology remains the gold standard for cancer diagnosis and prognosis. With the advent of transcriptome profiling, multi-modal learning combining transcriptomics with histology offers more comprehensive information. However, existing…

Image and Video Processing · Electrical Eng. & Systems 2026-03-03 Yupei Zhang , Xiaofei Wang , Anran Liu , Lequan Yu , Chao Li

The rapidly emerging field of deep learning-based computational pathology has shown promising results in utilizing whole slide images (WSIs) to objectively prognosticate cancer patients. However, most prognostic methods are currently…

Computer Vision and Pattern Recognition · Computer Science 2023-11-21 Mingxin Liu , Yunzan Liu , Hui Cui , Chunquan Li , Jiquan Ma

Multimodal deep learning has improved prognostic accuracy for brain tumours by integrating histopathology and genomic data, yet the contribution of volumetric MRI within unified survival frameworks remains unexplored. This pilot study…

Computer Vision and Pattern Recognition · Computer Science 2026-04-01 Iain Swift , JingHua Ye

Healthcare data now span EHRs, medical imaging, genomics, and wearable sensors, but most diagnostic models still process these modalities in isolation. This limits their ability to capture early, cross-modal disease signatures. This paper…

Machine Learning · Computer Science 2025-12-18 Md Talha Mohsin , Ismail Abdulrashid

The use of diverse modalities, such as omics, medical images, and clinical data can not only improve the performance of prognostic models but also deepen an understanding of disease mechanisms and facilitate the development of novel…

Image and Video Processing · Electrical Eng. & Systems 2025-08-14 Maria Boyko , Aleksandra Beliaeva , Dmitriy Kornilov , Alexander Bernstein , Maxim Sharaev

Predicting clinical outcome is remarkably important but challenging. Research efforts have been paid on seeking significant biomarkers associated with the therapy response or/and patient survival. However, these biomarkers are generally…

Machine Learning · Computer Science 2020-10-09 Jiancheng Yang , Jiajun Chen , Kaiming Kuang , Tiancheng Lin , Junjun He , Bingbing Ni

Multimodal survival prediction, a crucial yet challenging task, demands the integration of multimodal medical data (\eg Whole Slide Images (WSIs) and Genomic Profiles) to achieve accurate prognostic modeling. Given the inherent…

Computer Vision and Pattern Recognition · Computer Science 2026-05-21 Huayi Wang , Haochao Ying , Yuyang Xu , Qiyao Zheng , jun wang , Cheng Zhang , Ying Sun , Jian Wu

Cancer prognosis and survival outcome predictions are crucial for therapeutic response estimation and for stratifying patients into various treatment groups. Medical domains concerned with cancer prognosis are abundant with multiple…

Image and Video Processing · Electrical Eng. & Systems 2024-02-29 Ruining Deng , Nazim Shaikh , Gareth Shannon , Yao Nie