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Pervasive across diverse domains, stochastic systems exhibit fluctuations in processes ranging from molecular dynamics to climate phenomena. The Langevin equation has served as a common mathematical model for studying such systems, enabling…

Statistical Mechanics · Physics 2025-05-01 Youngkyoung Bae , Seungwoong Ha , Hawoong Jeong

Far-from-equilibrium many-body systems, from soap bubbles to suspensions to polymers, learn the drives that push them. This learning has been observed via thermodynamic properties, such as work absorption and strain. We move beyond these…

Statistical Mechanics · Physics 2020-04-08 Weishun Zhong , Jacob M. Gold , Sarah Marzen , Jeremy L. England , Nicole Yunger Halpern

Understanding the dynamics of a system is important in many scientific and engineering domains. This problem can be approached by learning state transition rules from observations using machine learning techniques. Such observed time-series…

Machine Learning · Computer Science 2022-12-08 Koji Watanabe , Katsumi Inoue

The dynamics of biological systems, from proteins to cells to organisms, is complex and stochastic. To decipher their physical laws, we need to bridge between experimental observations and theoretical modeling. Thanks to progress in…

Soft Condensed Matter · Physics 2024-06-05 Pierre Ronceray

In traditional thermodynamical and statistical-mechanical approaches one has (some) detailed knowledge of the principles governing the microdynamics of a system. However in many instances we may not have a Hamiltonian or good information…

Statistical Mechanics · Physics 2007-05-23 David Ford

A new theoretical approach to non-equilibrium statistical systems has recently been proposed by the author, a co-author and others. It is based on a variational principle which is associated with the discrepancy of a path through…

Statistical Mechanics · Physics 2019-08-06 Richard Kleeman

Information Bottleneck (IB) is a widely used framework that enables the extraction of information related to a target random variable from a source random variable. In the objective function, IB controls the trade-off between data…

Machine Learning · Computer Science 2025-08-13 Sota Kudo , Naoaki Ono , Shigehiko Kanaya , Ming Huang

We propose a new approach concerning the introduction of time-irreversibility in statistical mechanics. It is based on a transition function defined in terms of path integral and verifying a time-irreversible equation. We show first how…

Statistical Mechanics · Physics 2015-03-02 J. P. Badiali

In this paper, we discuss information-theoretic tools for obtaining optimized coarse-grained molecular models for both equilibrium and non-equilibrium molecular dynamics. The latter are ubiquitous in physicochemical and biological…

Numerical Analysis · Mathematics 2016-04-20 Vagelis Harmandaris , Evangelia Kalligiannaki , Markos A. Katsoulakis , Petr Plecháč

For multilayer materials in thin substrate systems, interfacial failure is one of the most challenges. The traction-separation relations (TSR) quantitatively describe the mechanical behavior of a material interface undergoing openings,…

Computational Engineering, Finance, and Science · Computer Science 2020-12-01 Jiaxin Zhang , Congjie Wei , Chenglin Wu

Equilibrium statistical mechanics provides a robust framework for characterizing phase transitions in systems whose microsopic dynamics are time-reversible. Efforts to develop and validate theoretical frameworks for time-irreversible,…

Soft Condensed Matter · Physics 2025-12-18 Stuart J. Thomson , Jack-William Barotta , Daniel M. Harris

Stochastic thermodynamics is the field of study relating fluctuations in stochastic systems to thermodynamic quantities. The total entropy production (EP), is central to the thermodynamic classification of systems. Non-equilibrium systems…

Statistical Mechanics · Physics 2025-08-05 Lars Torbjørn Stutzer

Markov state models (MSMs) are valuable for studying dynamics of protein conformational changes via statistical analysis of molecular dynamics (MD) simulations. In MSMs, the complex configuration space is coarse-grained into conformational…

Biological Physics · Physics 2024-06-11 Dedi Wang , Yunrui Qiu , Eric Beyerle , Xuhui Huang , Pratyush Tiwary

A fundamental challenge is to understand nonequilibrium statistical mechanics starting from microscopic chaos in the equations of motion of a many-particle system. In this review we summarize recent theoretical advances along these lines.…

Chaotic Dynamics · Physics 2010-01-04 R. Klages

We investigate the motion of a colloidal particle driven out of equilibrium by an external torque. We use the molecular dynamics simulation that is alternative to the numerical integration approach based on the Langevin equation and is…

Statistical Mechanics · Physics 2017-03-08 Donghwan Yoo , Youngkyun Jung , Chulan Kwon

We study a special case of the problem of statistical learning without the i.i.d. assumption. Specifically, we suppose a learning method is presented with a sequence of data points, and required to make a prediction (e.g., a classification)…

Machine Learning · Computer Science 2018-05-22 Steve Hanneke , Liu Yang

Information bottleneck (IB) is a paradigm to extract information in one target random variable from another relevant random variable, which has aroused great interest due to its potential to explain deep neural networks in terms of…

Information Theory · Computer Science 2023-08-23 Lingyi Chen , Shitong Wu , Wenhao Ye , Huihui Wu , Hao Wu , Wenyi Zhang , Bo Bai , Yining Sun

Information bottleneck (IB) is a technique for extracting information in one random variable $X$ that is relevant for predicting another random variable $Y$. IB works by encoding $X$ in a compressed "bottleneck" random variable $M$ from…

Information Theory · Computer Science 2022-11-22 Artemy Kolchinsky , Brendan D. Tracey , David H. Wolpert

The Information Bottleneck (IB) method is an information theoretical framework to design a parsimonious and tunable feature-extraction mechanism, such that the extracted features are maximally relevant to a specific learning or inference…

Signal Processing · Electrical Eng. & Systems 2024-04-17 Francesco Binucci , Paolo Banelli , Paolo Di Lorenzo , Sergio Barbarossa

We study the training and performance of physics-informed learning for initial and boundary value problems (IBVP) with physics-informed neural networks (PINNs) from a statistical learning perspective. Specifically, we restrict ourselves to…

Machine Learning · Computer Science 2026-02-12 David A. Barajas-Solano