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We study the problem of parameter estimation based on infection data from an epidemic outbreak on a graph. We assume that successive infections occur via contagion; i.e., transmissions can only spread across existing directed edges in the…

Statistics Theory · Mathematics 2018-06-15 Justin Khim , Po-Ling Loh

Classical compartmental models in epidemiology often assume a homogeneous population for simplicity, which neglects the inherent heterogeneity among individuals. This assumption frequently leads to inaccurate predictions when applied to…

Populations and Evolution · Quantitative Biology 2024-09-09 Ning Jiang , Weiqi Chu , Yao Li

Transmission models for infectious diseases are typically formulated in terms of dynamics between individuals or groups with processes such as disease progression or recovery for each individual captured phenomenologically, without…

We consider the edge-based compartmental models for infectious disease spread introduced in Part I. These models allow us to consider standard SIR diseases spreading in random populations. In this paper we show how to handle deviations of…

Populations and Evolution · Quantitative Biology 2015-09-03 Joel C. Miller , Erik M. Volz

Mathematical disease modelling has long operated under the assumption that any one infectious disease is caused by one transmissible pathogen spreading among a population. This paradigm has been useful in simplifying the biological reality…

Populations and Evolution · Quantitative Biology 2021-06-02 Blake J. M. Williams , Guillaume St-Onge , Laurent Hébert-Dufresne

An individual-based model of the infectious disease spread among the urban population is considered. A system of stochastic equations, which describes changes in quantities of four population groups, susceptible, exposed, infected…

Populations and Evolution · Quantitative Biology 2011-11-11 Vasiliy Leonenko

This paper gives an introduction to rule-based modelling applied to topics in infectious diseases. Rule-based models generalise reaction-based models with reagents that have internal state and may be bound together to form complexes, as in…

Populations and Evolution · Quantitative Biology 2021-08-10 William Waites , Matteo Cavaliere , David Manheim , Jasmina Panovska-Griffiths , Vincent Danos

The recent COVID-19 pandemic has shown that when the reproduction number is high and there are no proper measurements in place, the number of infected people can increase dramatically in a short time, producing a phenomenon that many…

Populations and Evolution · Quantitative Biology 2022-09-20 Jonathan A. Chávez Casillas

Previous work has shown that for contagion processes on extended star networks (trees with exactly one node of degree > 2), there is a simple, closed-form expression for a highly accurate approximation to the maximum likelihood infection…

Signal Processing · Electrical Eng. & Systems 2020-10-23 Sam Spencer , Lav R. Varshney

The COVID-19 pandemic provides new motivation for a classic problem in epidemiology: estimating the empirical rate of transmission during an outbreak (formally, the time-varying reproduction number) from case counts. While standard methods…

Methodology · Statistics 2020-12-08 Bryan Wilder , Michael J. Mina , Milind Tambe

We study the problem of estimating the origin of an epidemic outbreak -- given a contact network and a snapshot of epidemic spread at a certain time, determine the infection source. Finding the source is important in different contexts of…

Physics and Society · Physics 2014-11-20 Andrey Y. Lokhov , Marc Mézard , Hiroki Ohta , Lenka Zdeborová

This article examines how diseases on random networks spread in time. The disease is described by a probability distribution function for the number of infected and recovered individuals, and the probability distribution is described by a…

Adaptation and Self-Organizing Systems · Physics 2013-05-29 M. Marder

Global strategies to contain a pandemic, such as social distancing and protective measures, are designed to reduce the overall transmission rate between individuals. Despite such measures, essential institutions, including hospitals,…

Populations and Evolution · Quantitative Biology 2022-09-07 Roberto Morán-Tovar , Henning Gruell , Florian Klein , Michael Lässig

Epidemic outbreaks of new pathogens, or known pathogens in new populations, cause a great deal of fear because they are hard to predict. For theoretical models of disease spreading, on the other hand, quantities characterizing the outbreak…

Populations and Evolution · Quantitative Biology 2015-05-20 Petter Holme , Taro Takaguchi

In the first part of this paper, we review old and new results about the influence of host population heterogeneity on (various characteristics of) epidemic outbreaks. In the second part we highlight a modelling issue that so far has…

Populations and Evolution · Quantitative Biology 2024-01-17 Martin Bootsma , Danny Chan , Odo Diekmann , Hisashi Inaba

Infectious diseases spread via pathogens such as viruses and bacteria. Airborne pathogen transmission via droplets is an important mode for infectious diseases. In this paper, the spreading mechanism of infectious diseases by airborne…

Signal Processing · Electrical Eng. & Systems 2020-07-16 Fatih Gulec , Baris Atakan

The interplay of biological, social, structural and random factors makes disease forecasting extraordinarily complex. The course of an epidemic exhibits average growth dynamics determined by features of the pathogen and the population, yet…

Populations and Evolution · Quantitative Biology 2022-02-24 Andrea J. Allen , Mariah C. Boudreau , Nicholas J. Roberts , Antoine Allard , Laurent Hébert-Dufresne

We couple a multi-type stochastic epidemic process with a directed random graph, where edges have random lengths. This random graph representation is used to characterise the fractions of individuals infected by the different types of…

Probability · Mathematics 2018-01-29 Tom Britton , Ka Yin Leung , Pieter Trapman

In numerous contexts, individuals may decide whether they take actions to mitigate the spread of disease, or not. Mitigating the spread of disease requires an individual to change their routine behaviours to benefit others, resulting in a…

Physics and Society · Physics 2020-08-11 Julie Rowlett , Carl-Joar Karlsson

Random walk is one of the basic mechanisms found in many network applications. We study the epidemic spreading dynamics driven by biased random walks on complex networks. In our epidemic model, each time infected nodes constantly spread…

Physics and Society · Physics 2015-06-22 Cunlai Pu , Siyuan Li , Jian Yang