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We derive rigorous results describing the asymptotic dynamics of a discrete time model of spiking neurons introduced in \cite{BMS}. Using symbolic dynamic techniques we show how the dynamics of membrane potential has a one to one…

Dynamical Systems · Mathematics 2008-02-12 B. Cessac

This chapter revisits the concept of excitability, a basic system property of neurons. The focus is on excitable systems regarded as behaviors rather than dynamical systems. By this we mean open systems modulated by specific interconnection…

Neurons and Cognition · Quantitative Biology 2017-04-18 Rodolphe Sepulchre , Guillaume Drion , Alessio Franci

In this paper we study the hydrodynamic limit for a stochastic process describing the time evolution of the membrane potentials of a system of neurons with spatial dependency. We do not impose on the neurons mean-field type interactions.…

Probability · Mathematics 2017-07-14 Aline Duarte , Guilherme Ost , Andrés Rodríguez

This paper introduces a novel approach for modelling time-varying connectivity in neuroimaging data, focusing on the slow fluctuations in synaptic efficacy that mediate neuronal dynamics. Building on the framework of Dynamic Causal…

Neurons and Cognition · Quantitative Biology 2024-12-05 Johan Medrano , Karl J. Friston , Peter Zeidman

Understanding how the brain learns to compute functions reliably, efficiently and robustly with noisy spiking activity is a fundamental challenge in neuroscience. Most sensory and motor tasks can be described as dynamical systems and could…

Neurons and Cognition · Quantitative Biology 2017-05-24 Sophie Denève , Alireza Alemi , Ralph Bourdoukan

Novel experimental techniques reveal the simultaneous activity of larger and larger numbers of neurons. As a result there is increasing interest in the structure of cooperative -- or correlated -- activity in neural populations, and in the…

Neurons and Cognition · Quantitative Biology 2015-05-30 James Trousdale , Yu Hu , Eric Shea-Brown , Krešimir Josić

In this article we present a biologically inspired model of activation of memory items in a sequence. Our model produces two types of sequences, corresponding to two different types of cerebral functions: activation of regular or irregular…

Neurons and Cognition · Quantitative Biology 2020-07-01 Elif Köksal-Ersöz , Carlos Aguilar , Pascal Chossat , Martin Krupa , Frédéric Lavigne

Foundation models have shown remarkable success in fitting biological visual systems; however, their black-box nature inherently limits their utility for understanding brain function. Here, we peek inside a SOTA foundation model of neural…

Neurons and Cognition · Quantitative Biology 2026-01-30 Johannes Bertram , Luciano Dyballa , Anderson Keller , Savik Kinger , Steven W. Zucker

Cortical neurons are subject to sustained and irregular synaptic activity which causes important fluctuations of the membrane potential (Vm). We review here different methods to characterize this activity and its impact on spike generation.…

Neurons and Cognition · Quantitative Biology 2009-04-29 Zuzanna Piwkowska , Martin Pospischil , Romain Brette , Julia Sliwa , Michelle Rudolph-Lilith , Thierry Bal , Alain Destexhe

The deep neural nets of modern artificial intelligence (AI) have not achieved defining features of biological intelligence, including abstraction, causal learning, and energy-efficiency. While scaling to larger models has delivered…

Neurons and Cognition · Quantitative Biology 2021-05-24 Joseph D. Monaco , Kanaka Rajan , Grace M. Hwang

This paper introduces a model of excitability that unifies the mechanism of an important neuronal property both in time and in space. As a starting point, we revisit both a key model of temporal excitability, proposed by Hodgkin and Huxley,…

Systems and Control · Electrical Eng. & Systems 2025-05-29 Thomas SJ Burger , Amir Shahhosseini , Rodolphe Sepulchre

The analyses presented herein demonstrate that neuronal electrical activity can be consistently interpreted as a manifestation of murburn redox-mediated electronic dynamics rather than as a process fundamentally driven by transmembrane…

Neurons and Cognition · Quantitative Biology 2026-05-04 Kelath Murali Manoj , Nagamani Sukumar

Even as machine learning exceeds human-level performance on many applications, the generality, robustness, and rapidity of the brain's learning capabilities remain unmatched. How cognition arises from neural activity is a central open…

Neural and Evolutionary Computing · Computer Science 2023-10-17 Max Dabagia , Christos H. Papadimitriou , Santosh S. Vempala

Active contributions to fluctuations are a direct consequence of metabolic energy consumption in living cells. Such metabolic processes continuously create active forces, which deform the membrane to control motility, proliferation as well…

Biological Physics · Physics 2018-10-02 Hervé Turlier , Timo Betz

Agent-based modeling is a paradigm of modeling dynamic systems of interacting agents that are individually governed by specified behavioral rules. Training a model of such agents to produce an emergent behavior by specification of the…

Machine Learning · Computer Science 2019-10-11 Karan K. Budhraja , Hang Gao , Tim Oates

Complexity in the temporal organization of neural systems may be a reflection of the diversity of its neural constituents. These constituents, excitatory and inhibitory neurons, comprise an invariant ratio in vivo and form the substrate for…

Neurons and Cognition · Quantitative Biology 2015-05-18 Xin Chen , Rhonda Dzakpasu

Neural activity fluctuates over a wide range of timescales within and across brain areas. Experimental observations suggest that diverse neural timescales reflect information in dynamic environments. However, how timescales are defined and…

Neurons and Cognition · Quantitative Biology 2026-01-21 Roxana Zeraati , Anna Levina , Jakob H. Macke , Richard Gao

This paper introduces a class of stochastic models of interacting neurons with emergent dynamics similar to those seen in local cortical populations, and compares them to very simple reduced models driven by the same mean excitatory and…

Neurons and Cognition · Quantitative Biology 2017-11-07 Yao Li , Logan Chariker , Lai-Sang Young

The experimental study of neural networks requires simultaneous measurements of a massive number of neurons, while monitoring properties of the connectivity, synaptic strengths and delays. Current technological barriers make such a mission…

Neurons and Cognition · Quantitative Biology 2016-01-12 Amir Goldental , Pinhas Sabo , Shira Sardi , Roni Vardi , Ido Kanter

The human brain is one of the most complex and intriguing scientific topics. The most established theory on neuronal communication is a pure electrical model based on the propagation of intracell cationic charges along the neurons. Here we…

Neurons and Cognition · Quantitative Biology 2024-03-26 Francisco Meseguer , Fernando Ramiro-Manzano