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Depression remains a pressing global mental health issue, driving considerable research into AI-driven detection approaches. While pre-trained models, particularly speech self-supervised models (SSL Models), have been applied to depression…

Audio and Speech Processing · Electrical Eng. & Systems 2025-03-11 Xiangyu Zhang , Beena Ahmed , Julien Epps

Depression has proven to be a significant public health issue, profoundly affecting the psychological well-being of individuals. If it remains undiagnosed, depression can lead to severe health issues, which can manifest physically and even…

Human-Computer Interaction · Computer Science 2024-12-03 Chayan Tank , Sarthak Pol , Vinayak Katoch , Shaina Mehta , Avinash Anand , Rajiv Ratn Shah

Depression is a critical concern in global mental health, prompting extensive research into AI-based detection methods. Among various AI technologies, Large Language Models (LLMs) stand out for their versatility in mental healthcare…

Audio and Speech Processing · Electrical Eng. & Systems 2024-09-25 Xiangyu Zhang , Hexin Liu , Kaishuai Xu , Qiquan Zhang , Daijiao Liu , Beena Ahmed , Julien Epps

Background Major depressive disorder (MDD) is a leading cause of global disability, yet current diagnostic approaches often rely on subjective assessments and lack the ability to integrate multimodal clinical information. Large language…

Machine Learning · Computer Science 2025-09-30 Yuyang Sha , Hongxin Pan , Gang Luo , Caijuan Shi , Jing Wang , Kefeng Li

Depressive and anxiety disorders are widespread, necessitating timely identification and management. Recent advances in Large Language Models (LLMs) offer potential solutions, yet high costs and ethical concerns about training data remain…

Computation and Language · Computer Science 2025-01-28 June M. Liu , Mengxia Gao , Sahand Sabour , Zhuang Chen , Minlie Huang , Tatia M. C. Lee

Static tools like the Patient Health Questionnaire-9 (PHQ-9) effectively screen depression but lack interactivity and adaptability. We developed HopeBot, a chatbot powered by a large language model (LLM) that administers the PHQ-9 using…

Artificial Intelligence · Computer Science 2026-01-15 Zhijun Guo , Alvina Lai , Julia Ive , Alexandru Petcu , Yutong Wang , Luyuan Qi , Johan H Thygesen , Kezhi Li

Large language models (LLMs) are increasingly being used in a zero-shot fashion to assess mental health conditions, yet we have limited knowledge on what factors affect their accuracy. In this study, we utilize a clinical dataset of natural…

Conversational Agents (CAs) powered with deep language models (DLMs) have shown tremendous promise in the domain of mental health. Prominently, the CAs have been used to provide informational or therapeutic services to patients. However,…

Artificial Intelligence · Computer Science 2023-01-10 Shrey Gupta , Anmol Agarwal , Manas Gaur , Kaushik Roy , Vignesh Narayanan , Ponnurangam Kumaraguru , Amit Sheth

Use of large language models such as ChatGPT (GPT-4/GPT-5) for mental health support has grown rapidly, emerging as a promising route to assess and help people with mood disorders like depression. However, we have a limited understanding of…

Depression has impacted millions of people worldwide and has become one of the most prevalent mental disorders. Early mental disorder detection can lead to cost savings for public health agencies and avoid the onset of other major…

Computation and Language · Computer Science 2025-01-03 Giuliano Lorenzoni , Pedro Elkind Velmovitsky , Paulo Alencar , Donald Cowan

Automated depression diagnosis aims to analyze multimodal information from interview videos to predict participants' depression scores. Previous studies often lack clear explanations of how these scores were determined, limiting their…

Artificial Intelligence · Computer Science 2026-03-19 Wei Zhang , Juan Chen , En Zhu , Wenhong Cheng , YunPeng Li , Yanbo J. Wang

Automating data extraction from full-text randomised controlled trials (RCTs) for meta-analysis remains a significant challenge. This study evaluates the practical performance of three LLMs (Gemini-2.0-flash, Grok-3, GPT-4o-mini) across…

Computation and Language · Computer Science 2025-07-22 Lingbo Li , Anuradha Mathrani , Teo Susnjak

This paper proposes a new depression detection system based on LLMs that is both interpretable and interactive. It not only provides a diagnosis, but also diagnostic evidence and personalized recommendations based on natural language…

Computation and Language · Computer Science 2023-05-10 Wei Qin , Zetong Chen , Lei Wang , Yunshi Lan , Weijieying Ren , Richang Hong

Automatic detection of depression is a rapidly growing field of research at the intersection of psychology and machine learning. However, with its exponential interest comes a growing concern for data privacy and scarcity due to the…

Machine Learning · Computer Science 2024-11-27 Andrea Kang , Jun Yu Chen , Zoe Lee-Youngzie , Shuhao Fu

Large Language Models (LLMs) have been increasingly adopted for health-related tasks, yet their performance in depression detection remains limited when relying solely on text input. While Retrieval-Augmented Generation (RAG) typically…

Audio and Speech Processing · Electrical Eng. & Systems 2025-05-26 Xiangyu Zhang , Hexin Liu , Qiquan Zhang , Beena Ahmed , Julien Epps

The current work investigates the capability of Large language models (LLMs) that are explicitly trained on large corpuses of medical knowledge (Med-PaLM 2) to predict psychiatric functioning from patient interviews and clinical…

Computation and Language · Computer Science 2023-08-04 Isaac R. Galatzer-Levy , Daniel McDuff , Vivek Natarajan , Alan Karthikesalingam , Matteo Malgaroli

Alzheimer's Disease (AD) is a progressive neurodegenerative disorder that leads to dementia, and early intervention can greatly benefit from analyzing linguistic abnormalities. In this work, we explore the potential of Large Language Models…

Computation and Language · Computer Science 2025-12-23 Chuyuan Li , Raymond Li , Thalia S. Field , Giuseppe Carenini

Depression is one of the most prevalent mental health disorders globally. In recent years, multi-modal data, such as speech, video, and transcripts, has been increasingly used to develop AI-assisted depression assessment systems. Large…

With more than 300 million people depressed worldwide, depression is a global problem. Due to access barriers such as social stigma, cost, and treatment availability, 60% of mentally-ill adults do not receive any mental health services.…

Computer Vision and Pattern Recognition · Computer Science 2018-11-28 Albert Haque , Michelle Guo , Adam S Miner , Li Fei-Fei

We employ a Large Language Model (LLM) to convert unstructured psychological interviews into structured questionnaires spanning various psychiatric and personality domains. The LLM is prompted to answer these questionnaires by impersonating…

Computation and Language · Computer Science 2024-06-12 Gony Rosenman , Lior Wolf , Talma Hendler