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Epigenetic observations are represented by the total number of reads from a given pool of cells and the number of methylated reads, making it reasonable to model this data by a binomial distribution. There are numerous factors that can…

Applications · Statistics 2020-04-29 Aliaksandr Hubin , Geir O Storvik , Paul E Grini , Melinka A Butenko

In electronic health records (EHRs), latent subgroups of patients may exhibit distinctive patterning in their longitudinal health trajectories. For such data, growth mixture models (GMMs) enable classifying patients into different latent…

Methodology · Statistics 2022-01-12 Rebecca Anthopolos , Ying Wei , Qixuan Chen

The Allee effect is an important phenomenon in population biology characterized by positive density dependence, that is a positive correlation between population density and individual fitness. However, the effect is not well studied in…

Analysis of PDEs · Mathematics 2015-10-20 Rana D. Parshad , Emmanuel Quansah , Kelly Black , Nitu Kumari , Ranjit K. Upadhyay , S. K. Tiwari

We introduce a random partition model for Bayesian nonparametric regression. The model is based on infinitely-many disjoint regions of the range of a latent covariate-dependent Gaussian process. Given a realization of the process, the…

Methodology · Statistics 2013-01-04 George Karabatsos , Stephen G. Walker

Sustained high levels of blood glucose in type 2 diabetes (T2DM) can have disastrous long-term health consequences. An essential component of clinical interventions for T2DM is monitoring dietary intake to keep plasma glucose levels within…

Quantitative Methods · Quantitative Biology 2022-06-24 Zepeng Huo , Bobak J. Mortazavi , Theodora Chaspari , Nicolaas Deutz , Laura Ruebush , Ricardo Gutierrez-Osuna

Empirical researchers are usually interested in investigating the impacts of baseline covariates have when uncovering sample heterogeneity and separating samples into more homogeneous groups. However, a considerable number of studies in the…

Methodology · Statistics 2022-05-10 Jin Liu , Le Kang , Roy T. Sabo , Robert M. Kirkpatrick , Robert A. Perera

Modeling the dynamics of probability distributions from time-dependent data samples is a fundamental problem in many fields, including digital health. The goal is to analyze how the distribution of a biomarker, such as glucose, changes over…

Machine Learning · Statistics 2025-09-18 Antonio Álvarez-López , Marcos Matabuena

The development of statistical approaches for the joint modelling of the temporal changes of imaging, biochemical, and clinical biomarkers is of paramount importance for improving the understanding of neurodegenerative disorders, and for…

Applications · Statistics 2018-02-16 Marco Lorenzi , Maurizio Filippone , Daniel C. Alexander , Sebastien Ourselin

Addressing health disparities among different demographic groups is a key challenge in public health. Despite many efforts, there is still a gap in understanding how these disparities unfold over time. Our paper focuses on this overlooked…

Applications · Statistics 2024-04-19 Sang Kyu Lee , Seonjin Kim , Mi-Ok Kim , Katherine L. Grantz , Hyokyoung G. Hong

In clinical practice and biomedical research, measurements are often collected sparsely and irregularly in time while the data acquisition is expensive and inconvenient. Examples include measurements of spine bone mineral density, cancer…

Machine Learning · Statistics 2021-08-05 Łukasz Kidziński , Trevor Hastie

Estimating heterogeneous treatment effects across individuals has attracted growing attention as a statistical tool for performing critical decision-making. We propose a Bayesian inference framework that quantifies the uncertainty in…

Methodology · Statistics 2023-12-19 Shunsuke Horii , Yoichi Chikahara

Although tissues are usually studied in isolation, this situation rarely occurs in biology, as cells, tissues, and organs, coexist and interact across scales to determine both shape and function. Here, we take a quantitative approach…

Tissues and Organs · Quantitative Biology 2023-02-07 Carles Falcó , Daniel J. Cohen , José A. Carrillo , Ruth E. Baker

Multi-dimensional functional data arises in numerous modern scientific experimental and observational studies. In this paper we focus on longitudinal functional data, a structured form of multidimensional functional data. Operating within a…

Methodology · Statistics 2019-09-20 John Shamshoian , Damla Senturk , Shafali Jeste , Donatello Telesca

We demonstrate the use of a multidimensional extension of the latent Markov model to analyse data from studies with correlated binary responses in developmental psychology. In particular, we consider an experiment based on a battery of…

Applications · Statistics 2025-01-08 Francesco Bartolucci , Ivonne L. Solis-Trapala

We consider the problem of model choice for stochastic epidemic models given partial observation of a disease outbreak through time. Our main focus is on the use of Bayes factors. Although Bayes factors have appeared in the epidemic…

Computation · Statistics 2017-10-16 Muteb Alharthi , Theodore Kypraios , Philip D. O'Neill

The identification of factors associated with mental and behavioral disorders in early childhood is critical both for psychopathology research and the support of primary health care practices. Motivated by the Millennium Cohort Study, in…

Methodology · Statistics 2021-09-15 Luca Merlo , Lea Petrella , Nikos Tzavidis

The lack of longitudinal studies of the relationship between the built environment and travel behavior has been widely discussed in the literature. This paper discusses how standard propensity score matching estimators can be extended to…

Econometrics · Economics 2019-11-06 Haotian Zhong , Wei Li , Marlon G. Boarnet

We propose a flexible Bayesian approach for estimating the joint density of a multivariate outcome of interest in the presence of categorical covariates. Leveraging a Gaussian copula framework, our method effectively captures the dependence…

Methodology · Statistics 2026-04-10 Giovanni Toto , Peter Müller , Abhra Sarkar

The nutritional quality of diets has significantly deteriorated over the past two to three decades, a decline often underestimated by the people. This deterioration, coupled with a hectic lifestyle, has contributed to escalating health…

Computer Vision and Pattern Recognition · Computer Science 2024-03-05 Assylzhan Izbassar , Pakizar Shamoi

We develop a semiparametric Bayesian approach for estimating the mean response in a missing data model with binary outcomes and a nonparametrically modelled propensity score. Equivalently we estimate the causal effect of a treatment,…

Statistics Theory · Mathematics 2020-09-23 Kolyan Ray , Aad van der Vaart