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Phage display is a powerful laboratory technique used to study the interactions between proteins and other molecules, whether other proteins, peptides, DNA or RNA. The under-utilisation of this data in conjunction with deep learning models…

Populations and Evolution · Quantitative Biology 2026-01-08 Ilann Amiaud-Plachy , Michael Blank , Oliver Bent , Sebastien Boyer

Protein retrieval, which targets the deconstruction of the relationship between sequences, structures and functions, empowers the advancing of biology. Basic Local Alignment Search Tool (BLAST), a sequence-similarity-based algorithm, has…

Information Retrieval · Computer Science 2025-01-06 Yuxuan Wu , Xiao Yi , Yang Tan , Huiqun Yu , Guisheng Fan , Gaowei Zheng

Identifying predictive covariates, which forecast individual treatment effectiveness, is crucial for decision-making across different disciplines such as personalized medicine. These covariates, referred to as biomarkers, are extracted from…

Image and Video Processing · Electrical Eng. & Systems 2024-12-10 Shuhan Xiao , Lukas Klein , Jens Petersen , Philipp Vollmuth , Paul F. Jaeger , Klaus H. Maier-Hein

This paper introduces an adaptive filtering process based on shrinking wavelet coefficients from the corresponding signal wavelet representation. The filtering procedure considers a threshold method determined by an iterative algorithm…

Methodology · Statistics 2023-07-21 F. M. Bayer , A. J. Kozakevicius , R. J. Cintra

DNA-encoded small molecule libraries (DELs) have enabled discovery of novel inhibitors for many distinct protein targets of therapeutic value through screening of libraries with up to billions of unique small molecules. We demonstrate a new…

Automated assessment of human motion plays a vital role in rehabilitation, enabling objective evaluation of patient performance and progress. Unlike general human activity recognition, rehabilitation motion assessment focuses on analyzing…

Computer Vision and Pattern Recognition · Computer Science 2025-07-29 Ali Ismail-Fawaz , Maxime Devanne , Stefano Berretti , Jonathan Weber , Germain Forestier

Deep learning has become an extremely powerful tool for complex tasks such as image classification and segmentation. The medical industry often lacks high-quality, balanced datasets, which can be a challenge for deep learning algorithms…

Image and Video Processing · Electrical Eng. & Systems 2024-03-26 Muhammad Shoaib Farooq , Ayesha Tariq

Identifying one or more biologically-active/native decoys from millions of non-native decoys is one of the major challenges in computational structural biology. The extreme lack of balance in positive and negative samples (native and…

Biomolecules · Quantitative Biology 2020-10-06 Nasrin Akhter , Gopinath Chennupati , Hristo Djidjev , Amarda Shehu

Worldwide, several cases go undiagnosed due to poor healthcare support in remote areas. In this context, a centralized system is needed for effective monitoring and analysis of the medical records. A web-based patient diagnostic system is a…

Computer Vision and Pattern Recognition · Computer Science 2021-07-06 Harish Rajora , Narinder Singh Punn , Sanjay Kumar Sonbhadra , Sonali Agarwal

Reliable analysis of intracellular dynamic processes in time-lapse fluorescence microscopy images requires complete and accurate tracking of all small particles in all time frames of the image sequences. A fundamental first step towards…

Image and Video Processing · Electrical Eng. & Systems 2024-08-16 Yao Yao , Ihor Smal , Ilya Grigoriev , Anna Akhmanova , Erik Meijering

Automatic detection of leukemic B-lymphoblast cancer in microscopic images is very challenging due to the complicated nature of histopathological structures. To tackle this issue, an automatic and robust diagnostic system is required for…

Image and Video Processing · Electrical Eng. & Systems 2019-09-27 Sara Hosseinzadeh Kassani , Peyman Hosseinzadeh kassani , Michal J. Wesolowski , Kevin A. Schneider , Ralph Deters

Extreme classification seeks to assign each data point, the most relevant labels from a universe of a million or more labels. This task is faced with the dual challenge of high precision and scalability, with millisecond level prediction…

Machine Learning · Computer Science 2019-05-29 Ankit Jalan , Purushottam Kar

Materials synthesis platforms that are designed for autonomous experimentation are capable of collecting multimodal diagnostic data that can be utilized for feedback to optimize material properties. Pulsed laser deposition (PLD) is emerging…

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PowerShell is a powerful and versatile task automation tool. Unfortunately, it is also widely abused by cyber attackers. To bypass malware detection and hinder threat analysis, attackers often employ diverse techniques to obfuscate…

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Cervical cancer, one of the most common fatal cancers among women, can be prevented by regular screening to detect any precancerous lesions at early stages and treat them. Pap smear test is a widely performed screening technique for early…

Image and Video Processing · Electrical Eng. & Systems 2021-08-31 Md Mamunur Rahaman , Chen Li , Yudong Yao , Frank Kulwa , Xiangchen Wu , Xiaoyan Li , Qian Wang

Pyserini is an easy-to-use Python toolkit that supports replicable IR research by providing effective first-stage retrieval in a multi-stage ranking architecture. Our toolkit is self-contained as a standard Python package and comes with…

Information Retrieval · Computer Science 2021-02-22 Jimmy Lin , Xueguang Ma , Sheng-Chieh Lin , Jheng-Hong Yang , Ronak Pradeep , Rodrigo Nogueira

As deep neural networks include a high number of parameters and operations, it can be a challenge to implement these models on devices with limited computational resources. Despite the development of novel pruning methods toward…

Computer Vision and Pattern Recognition · Computer Science 2023-06-27 Morteza Homayounfar , Mohamad Koohi-Moghadam , Reza Rawassizadeh , Varut Vardhanabhuti

The emergence of multi-parametric magnetic resonance imaging (mpMRI) has had a profound impact on the diagnosis of prostate cancers (PCa), which is the most prevalent malignancy in males in the western world, enabling a better selection of…

Biometrics-related research has been accelerated significantly by deep learning technology. However, there are limited open-source resources to help researchers evaluate their deep learning-based biometrics algorithms efficiently,…

Computer Vision and Pattern Recognition · Computer Science 2019-02-04 Xiang Xu , Ioannis A. Kakadiaris

Image classification is widely used to build predictive models for breast cancer diagnosis. Most existing approaches overwhelmingly rely on deep convolutional networks to build such diagnosis pipelines. These model architectures, although…

Image and Video Processing · Electrical Eng. & Systems 2022-01-20 Alireza Rezazadeh , Yasamin Jafarian , Ali Kord