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Although cell shape can reflect the mechanical and biochemical properties of the cell and its environment, quantification of 3D cell shapes within 3D tissues remains difficult, typically requiring digital reconstruction from a stack of 2D…

Quantitative Methods · Quantitative Biology 2019-03-06 Tristan A. Sharp , Matthias Merkel , M. Lisa Manning , Andrea J. Liu

Soft-granular media, such as dense emulsions, foams or tissues, exhibit either fluid- or solid-like properties depending on the applied external stresses. Whereas bulk rheology of such materials has been thoroughly investigated, the…

Soft Condensed Matter · Physics 2024-07-04 Michal Bogdan , Jesus Pineda , Mihir Durve , Leon Jurkiewicz , Sauro Succi , Giovanni Volpe , Jan Guzowski

Natural active systems routinely reshape and reorganize their environments through sustained local interactions. Examples of decentralized collective construction are common in nature, e.g., many insects achieve large-scale constructions…

Soft Condensed Matter · Physics 2025-11-04 Yuchen Xi , Tom Marzin , P. -T. Brun

The dynamics of cellular aggregates is driven by the interplay of mechanochemical processes and cellular activity. Although deterministic models may capture mechanical features, local chemical fluctuations trigger random cell responses,…

Soft Condensed Matter · Physics 2024-01-17 Ana Carpio , Elena Cebrian

The membrane curvature of cells and intracellular compartments continuously adapts to enable cells to perform vital functions, from cell division to signal trafficking. Understanding how membrane geometry affects these processes in vivo is…

Soft particles display highly versatile properties with respect to hard colloids, even more so at fluid-fluid interfaces. In particular, microgels, consisting of a cross-linked polymer network, are able to deform and flatten upon adsorption…

We study the elasto-plastic behaviour of materials made of individual (discrete) objects, such as a liquid foam made of bubbles. The evolution of positions and mutual arrangements of individual objects is taken into account through…

Soft Condensed Matter · Physics 2015-05-18 Christophe Raufaste , Simon Cox , Philippe Marmottant , François Graner

Pore-scale modeling and simulation of reactive flow in porous media has a range of diverse applications, and poses a number of research challenges. It is known that the morphology of a porous medium has significant influence on the local…

Computational Engineering, Finance, and Science · Computer Science 2015-07-09 Oleg Iliev , Zahra Lakdawala , Katherine Leonard , Yavor Vutov

The simulation of industrial processes involving cold compaction of powders allows for the optimization of the production of both traditional and advanced ceramics. The capabilities of a constitutive model previously proposed by the authors…

Materials Science · Physics 2014-04-30 S. Stupkiewicz , A. Piccolroaz , D. Bigoni

Thin bilayers made of elastic sheets with different strain recoveries can be used for dynamic shape morphing through ambient stimuli, such as temperature, mass diffusion, and light. As a fundamentally different approach to designing…

Soft Condensed Matter · Physics 2023-11-01 Wenya Shu , C. Nadir Kaplan , Justin R. Barone

Filaments are ubiquitous in the universe. Recent observations have revealed that stars and star clusters form preferentially along dense filaments. Understanding the formation and properties of filaments is therefore a crucial step in…

Solar and Stellar Astrophysics · Physics 2016-01-22 Christoph Federrath

Solid-state nanofoaming experiments are conducted on two PMMA grades of markedly different molecular weight using CO$_2$ as the blowing agent. The sensitivity of porosity to foaming time and foaming temperature is measured. Also, the…

From understanding the sand on the beach to the foam on your beer, soft sphere simulations have been crucial to the study of the amorphous world around us. However, many of the materials we interact with on a daily basis aren't comprised of…

Soft Condensed Matter · Physics 2024-03-18 R. C. Dennis

In this work we present a novel computational method for embedding arbitrary curved one-dimensional (1D) fibers into three-dimensional (3D) solid volumes, as e.g. in fiber-reinforced materials. The fibers are explicitly modeled with highly…

Computational Engineering, Finance, and Science · Computer Science 2023-08-25 Ivo Steinbrecher , Matthias Mayr , Maximilian J. Grill , Johannes Kremheller , Christoph Meier , Alexander Popp

Realistic microscale domains are an essential step towards making modern multiscale simulations more applicable to computational materials engineering. For this purpose, 3D computed tomography scans can be very expensive or technically…

We consider a multiscale approach based on immersed methods for the efficient computational modeling of tissues composed of an elastic matrix (in two or three-dimensions) and a thin vascular structure (treated as a co-dimension two…

Numerical Analysis · Mathematics 2021-11-18 Luca Heltai , Alfonso Caiazzo

For the first time the phenomenon of cellular structure coarsening are consistently analysed from the positions of kinetic, hydrodynamic and stochastodynamic theories of nonequilibrium statistical systems. Thereby micro-, meso- and…

Condensed Matter · Physics 2015-06-25 S. B. Goryachev

The evaluation of synthetic micro-structure images is an emerging problem as machine learning and materials science research have evolved together. Typical state of the art methods in evaluating synthetic images from generative models have…

Materials Science · Physics 2022-11-18 Devesh Shah , Anirudh Suresh , Alemayehu Admasu , Devesh Upadhyay , Kalyanmoy Deb

Cryo-electron microscopy can now routinely deliver atomic resolution structures for a variety of biological systems. The relevance and value of these structures is directly related to their ability to help rationalize experimental…

Computer simulations can aid in understanding how collective materials properties emerge from interactions between simple constituents. Here, we introduce a coarse-grained model that enables simulation of networks of actin filaments, myosin…

Biological Physics · Physics 2018-12-07 Simon L. Freedman , Shiladitya Banerjee , Glen M. Hocky , Aaron R. Dinner