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Biology is full of intricate molecular structures whose geometries are inextricably linked to their function. Many of these structures exhibit varying curvature, such as the helical structure of the bacterial flagellum, which is critical…

The hallmark feature of polymorphic systems is their ability to assemble into many possible structures at the same thermodynamic state. Designer polymorphic materials can in principle be engineered via programmable self-assembly, but the…

Soft Condensed Matter · Physics 2025-05-23 Fan Chen , William M. Jacobs

Isotropic pairwise interactions that promote the self assembly of complex particle morphologies have been discovered by inverse design strategies derived from the molecular coarse-graining literature. While such approaches provide an avenue…

Statistical Mechanics · Physics 2019-10-15 Beth A. Lindquist , Ryan B. Jadrich , Michael P. Howard , Thomas M. Truskett

We use numerical simulations to show how noninteracting hard particles binding to a deformable elastic shell may self-assemble into a variety of linear patterns. This is a result of the nontrivial elastic response to deformations of shells.…

Soft Condensed Matter · Physics 2011-02-25 Andela Šarić , Angelo Cacciuto

DNA-coated particles are promising as building blocks for functional and finite-sized assemblies because they can be programmed with orthogonal interactions owing to the sequence-specific hybridization of DNA strands. To fully exploit this…

Soft Condensed Matter · Physics 2026-04-17 T. C. M. Stevens , A. van der Sluis , I. K. Voets , P. G. Moerman

Mutually repelling particles form spontaneously ordered clusters when forced into confinement. The clusters may adopt similar spatial arrangements even if the underlying particle interactions are contrastingly different. Here we demonstrate…

Soft Condensed Matter · Physics 2026-02-13 P. D. S. de Lima , R. De La Cour , K. Gaff , J. M. de Araújo , S. J. Cox , M. S. Ferreira , S. Hutzler

Since the 1920s, packing arguments have been used to rationalize crystal structures in systems ranging from atomic mixtures to colloidal crystals. Packing arguments have recently been applied to complex nanoparticle structures, where they…

Soft Condensed Matter · Physics 2018-05-09 Rose Cersonsky , Greg van Anders , Paul M. Dodd , Sharon C. Glotzer

Self-assembly is one of the prevalent strategies used by living systems to fabricate ensembles of precision nanometer-scale structures and devices. The push for analogous approaches to create synthetic nanomaterials has led to the…

Flexibility governs the many properties of materials and is crucial for the function of proteins and biopolymers. However, how the self-assembly of flexibly bonded particles can lead to larger structures with global reconfigurability is…

Soft Condensed Matter · Physics 2024-06-28 Yogesh Shelke , Daniel J. G. Pearce , Daniela J. Kraft

Co-assembly of inorganic nanoparticles (NPs) and nanostructured polymer matrix represents an intricate interplay of enthalpic or entropic forces. Particle size largely affects the phase behavior of the nanocomposite. Theoretical studies…

Soft Condensed Matter · Physics 2022-04-25 Le Ma , Hejin Huang , Peter Ercius , Alfredo Alexander-Katz , Ting Xu

In soft matter science, it is often the goal to design new materials with targeted properties. These materials can be used in many applications, each requiring specific features to be optimized for maximum fitness. The use of self-assembly…

Biological Physics · Physics 2026-01-13 Luis Nieves-Rosado , Fernando Escobedo

Highly symmetric nano-shells are found in many biological systems, such as clathrin cages and viral shells. Several studies have shown that symmetric shells appear in nature as a result of the free energy minimization of a generic…

Soft Condensed Matter · Physics 2014-10-06 Jef Wagner , Roya Zandi

Designing components that can robustly self-assemble into structures with biological complexity is a grand challenge for material science. Proofreading and error correction is required to improve assembly yield beyond equilibrium limits,…

Soft Condensed Matter · Physics 2023-12-15 Qian-Ze Zhu , Chrisy Xiyu Du , Ella M. King , Michael P. Brenner

In recent experiments [T. Basta et al., Proc. Natl. Acad. Sci. U.S.A. 111, 670 (2014)] lipids and membrane proteins were observed to self-assemble into membrane protein polyhedral nanoparticles (MPPNs) with a well-defined polyhedral protein…

Biological Physics · Physics 2017-04-28 Di Li , Osman Kahraman , Christoph A. Haselwandter

Self-assembly is a ubiquitous process in synthetic and biological systems, broadly defined as the spontaneous organization of multiple subunits (e.g. macromolecules, particles) into ordered multi-unit structures. The vast majority of…

Soft Condensed Matter · Physics 2023-08-08 Michael F. Hagan , Gregory M. Grason

Polymer-grafted nanoparticles are versatile building blocks that self-assemble into a rich diversity of mesostructures. Coarse-grained molecular simulations have commonly accompanied experiments by resolving structure formation pathways and…

Soft Condensed Matter · Physics 2025-09-30 Federico Tomazic , Aswathy Muttathukattil , Afshin Nabiyan , Felix Schacher , Michael Engel

One of the fundamental goals of nanotechnology is to exploit selective and directional interactions between molecules to design particles that self-assemble into desired structures, from capsids, to nano-clusters, to fully formed crystals…

Soft Condensed Matter · Physics 2020-09-16 Flavio Romano , John Russo , Lukáš Kroc , Petr Šulc

Within simulations of molecules deposited on a surface we show that neuroevolutionary learning can design particles and time-dependent protocols to promote self-assembly, without input from physical concepts such as thermal equilibrium or…

Statistical Mechanics · Physics 2021-07-07 Stephen Whitelam , Isaac Tamblyn

DNA nanostructures with programmable shape and interactions can be used as building blocks for the self-assembly of crystalline materials with prescribed nanoscale features, holding a vast technological potential. Structural rigidity and…

Soft Condensed Matter · Physics 2019-01-30 Ryan A. Brady , William T. Kaufhold , Nicholas J. Brooks , Vito Foderà , Lorenzo Di Michele

The inverse problem of designing component interactions to target emergent structure is fundamental to numerous applications in biotechnology, materials science, and statistical physics. Equally important is the inverse problem of designing…

Computational Physics · Physics 2020-11-20 Carl P. Goodrich , Ella M. King , Samuel S. Schoenholz , Ekin D. Cubuk , Michael Brenner