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The most fundamental problem in statistical causality is determining causal relationships from limited data. Probability trees, which combine prior causal structures with Bayesian updates, have been suggested as a possible solution. In this…

Machine Learning · Computer Science 2022-05-19 Tue Herlau

Explaining machine learning (ML) predictions has become crucial as ML models are increasingly deployed in high-stakes domains such as healthcare. While SHapley Additive exPlanations (SHAP) is widely used for model interpretability, it fails…

Machine Learning · Computer Science 2025-09-03 Woon Yee Ng , Li Rong Wang , Siyuan Liu , Xiuyi Fan

Background: Predicting the efficacy of combination therapies is a critical challenge in clinical decision-making, particularly for diseases requiring multi-drug regimens. Traditional evidence synthesis methods, such as component network…

Quantitative Methods · Quantitative Biology 2025-03-31 Dipayan Sengupta , Saumya Panda

Chronic diseases, such as cardiovascular disease, diabetes, chronic kidney disease, and thyroid disorders, are the leading causes of premature mortality worldwide. Early detection and intervention are crucial for improving patient outcomes,…

Machine Learning · Computer Science 2025-11-04 Houda Belhad , Asmae Bourbia , Salma Boughanja

Causal inference is a vital aspect of multiple scientific disciplines and is routinely applied to high-impact applications such as medicine. However, evaluating the performance of causal inference methods in real-world environments is…

Machine Learning · Computer Science 2023-07-04 Mathieu Chevalley , Yusuf Roohani , Arash Mehrjou , Jure Leskovec , Patrick Schwab

We propose a constraint-based algorithm, which automatically determines causal relevance thresholds, to infer causal networks from data. We call these topological thresholds. We present two methods for determining the threshold: the first…

Machine Learning · Statistics 2024-04-24 Filipe Barroso , Diogo Gomes , Gareth J. Baxter

In recent years, research unveiled more and more evidence for the so-called Bayesian Brain Paradigm, i.e. the human brain is interpreted as a probabilistic inference machine and Bayesian modelling approaches are hence used successfully. One…

Neural and Evolutionary Computing · Computer Science 2019-04-30 Kevin Jasberg , Sergej Sizov

We propose Causal Interaction Trees for identifying subgroups of participants that have enhanced treatment effects using observational data. We extend the Classification and Regression Tree algorithm by using splitting criteria that focus…

Methodology · Statistics 2021-12-08 Jiabei Yang , Issa J. Dahabreh , Jon A. Steingrimsson

Prior-Data Fitted Networks (PFNs) represent a paradigm shift in tabular data prediction. We present the principles of this new paradigm and evaluate two PFNs for estimating the average treatment effect (ATE) of a binary treatment on a…

Causal inference has numerous real-world applications in many domains, such as health care, marketing, political science, and online advertising. Treatment effect estimation, a fundamental problem in causal inference, has been extensively…

Machine Learning · Computer Science 2023-02-03 Zhixuan Chu , Jianmin Huang , Ruopeng Li , Wei Chu , Sheng Li

Accurate predictions, as with machine learning, may not suffice to provide optimal healthcare for every patient. Indeed, prediction can be driven by shortcuts in the data, such as racial biases. Causal thinking is needed for data-driven…

Robust decision making involves making decisions in the presence of uncertainty and is often used in critical domains such as healthcare, supply chains, and finance. Causality plays a crucial role in decision-making as it predicts the…

Methodology · Statistics 2025-07-23 Saideep Nannapaneni , Joseph Sakaya , Kyle Caron , Pedro HM Albuquerque , Zaid Tashman

Causal inference has recently gained notable attention across various fields like biology, healthcare, and environmental science, especially within explainable artificial intelligence (xAI) systems, for uncovering the causal relationships…

Machine Learning · Computer Science 2025-01-13 Xiaofeng Xiao , Khawlah Alharbi , Pengyu Zhang , Hantang Qin , Xubo Yue

Recently the patient-centered medical home (PCMH) model has become a popular team-based approach focused on delivering more streamlined care to patients. In current practices of medical homes, a clinical-based prediction frame is…

Applications · Statistics 2014-02-27 Saeede Ajorlou , Issac Shams , Kai Yang

Concept Bottleneck Models (CBMs) enhance the interpretability of end-to-end neural networks by introducing a layer of concepts and predicting the class label from the concept predictions. A key property of CBMs is that they support…

Machine Learning · Computer Science 2026-03-03 Weixin Chen , Han Zhao

Cognitive Diagnosis~(CD), which leverages students and exercise data to predict students' proficiency levels on different knowledge concepts, is one of fundamental components in Intelligent Education. Due to the scarcity of student-exercise…

Machine Learning · Computer Science 2024-06-06 Dacao Zhang , Kun Zhang , Le Wu , Mi Tian , Richang Hong , Meng Wang

In causal inference, interference occurs when the treatment of one unit may affect the outcomes of other units. The goal of this work is to serve as a guide to the use of linear outcome modeling for estimating causal effects in settings…

Methodology · Statistics 2026-04-01 Eric Tong , Salvador V. Balkus

Feature selection is an important but challenging task in causal inference for obtaining unbiased estimates of causal quantities. Properly selected features in causal inference not only significantly reduce the time required to implement a…

Methodology · Statistics 2025-02-04 Tianyu Yang , Md. Noor-E-Alam

Long-running clinical trials offer a unique opportunity to study disease progression and treatment response over time, enabling questions about how and when interventions alter patient trajectories. However, drawing causal conclusions in…

Applications · Statistics 2025-08-13 Emma Prevot , Dieter A. Häring , Thomas E. Nichols , Chris C. Holmes , Habib Ganjgahi

No man is an island, as individuals interact and influence one another daily in our society. When social influence takes place in experiments on a population of interconnected individuals, the treatment on a unit may affect the outcomes of…

Methodology · Statistics 2017-08-30 Edward K. Kao