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We propose a numerical technique for parameter inference in Markov models of biological processes. Based on time-series data of a process we estimate the kinetic rate constants by maximizing the likelihood of the data. The computation of…

Quantitative Methods · Quantitative Biology 2011-02-15 Aleksandr Andreychenko , Linar Mikeev , David Spieler , Verena Wolf

We consider Markov decision processes (MDPs) in which the transition probabilities and rewards belong to an uncertainty set parametrized by a collection of random variables. The probability distributions for these random parameters are…

Logic in Computer Science · Computer Science 2020-02-26 Murat Cubuktepe , Nils Jansen , Sebastian Junges , Joost-Pieter Katoen , Ufuk Topcu

We first study labeled transition systems with explicit successful termination. We establish the notions of strong, weak, and branching bisimulation in terms of boolean matrix theory, introducing thus a novel and powerful algebraic…

Logic in Computer Science · Computer Science 2009-12-12 Nikola Trčka

Interactive Markov chains (IMC) are compositional behavioural models extending labelled transition systems and continuous-time Markov chains. We provide a framework and algorithms for compositional verification and optimization of IMC with…

Logic in Computer Science · Computer Science 2013-12-05 Holger Hermanns , Jan Krčál , Jan Křetínský

In the context of Markov decision processes running in continuous time, one of the most intriguing challenges is the efficient approximation of finite horizon reachability objectives. A multitude of sophisticated model checking algorithms…

Systems and Control · Computer Science 2015-08-03 Yuliya Butkova , Hassan Hatefi , Holger Hermanns , Jan Krcal

The generic identification problem is to decide whether a stochastic process $(X_t)$ is a hidden Markov process and if yes to infer its parameters for all but a subset of parametrizations that form a lower-dimensional subvariety in…

Statistics Theory · Mathematics 2015-01-14 Alexander Schönhuth

We propose a simple technique for verifying probabilistic models whose transition probabilities are parametric. The key is to replace parametric transitions by nondeterministic choices of extremal values. Analysing the resulting…

Logic in Computer Science · Computer Science 2016-05-27 Tim Quatmann , Christian Dehnert , Nils Jansen , Sebastian Junges , Joost-Pieter Katoen

In parametric lock-sharing systems processes can spawn new processes to run in parallel, and can create new locks. The behavior of every process is given by a pushdown automaton. We consider infinite behaviors of such systems under strong…

Logic in Computer Science · Computer Science 2023-07-12 Corto Mascle , Anca Muscholl , Igor Walukiewicz

Behavioural metrics have been shown to be an effective mechanism for constructing representations in reinforcement learning. We present a novel perspective on behavioural metrics for Markov decision processes via the use of positive…

Machine Learning · Computer Science 2023-11-01 Pablo Samuel Castro , Tyler Kastner , Prakash Panangaden , Mark Rowland

Markov chains are a natural and well understood tool for describing one-dimensional patterns in time or space. We show how to infer $k$-th order Markov chains, for arbitrary $k$, from finite data by applying Bayesian methods to both…

Statistics Theory · Mathematics 2009-11-13 Christopher C. Strelioff , James P. Crutchfield , Alfred W. Hubler

Fluid models are a popular formalism in the quantitative modeling of biochemical systems and analytical performance models. The main idea is to approximate a large-scale Markov chain by a compact set of ordinary differential equations…

Systems and Control · Computer Science 2019-05-02 Max Tschaikowski

Parametric Markov chains (pMCs) are Markov chains (MCs) with symbolic probabilities. A pMC encodes a family of MCs, where each member is obtained by replacing parameters with constants. The parameters allow encoding dependencies between…

Logic in Computer Science · Computer Science 2025-08-05 Linus Heck , Tim Quatmann , Jip Spel , Joost-Pieter Katoen , Sebastian Junges

Despite the extent of recent advances in Machine Learning (ML) and Neural Networks, providing formal guarantees on the behavior of these systems is still an open problem, and a crucial requirement for their adoption in regulated or…

Machine Learning · Computer Science 2024-10-01 Matteo Francobaldi , Michele Lombardi

We introduce a method to verify stochastic reinforcement learning (RL) policies. This approach is compatible with any RL algorithm as long as the algorithm and its corresponding environment collectively adhere to the Markov property. In…

Artificial Intelligence · Computer Science 2024-03-28 Dennis Gross , Helge Spieker

We introduce a class of models for multidimensional control problems which we call skip-free Markov decision processes on trees. We describe and analyse an algorithm applicable to Markov decision processes of this type that are skip-free in…

Optimization and Control · Mathematics 2013-11-11 E. J. Collins

Machine-learned systems are in widespread use for making decisions about humans, and it is important that they are fair, i.e., not biased against individuals based on sensitive attributes. We present runtime verification of algorithmic…

Computers and Society · Computer Science 2023-05-26 Thomas A. Henzinger , Mahyar Karimi , Konstantin Kueffner , Kaushik Mallik

In order to properly train a machine learning model, data must be properly collected. To guarantee a proper data collection, verifying that the collected data set holds certain properties is a possible solution. For example, guaranteeing…

Software Engineering · Computer Science 2021-08-26 Jorge López , Maxime Labonne , Claude Poletti

As machine learning is increasingly used in essential systems, it is important to reduce or eliminate the incidence of serious bugs. A growing body of research has developed machine learning algorithms with formal guarantees about…

Machine Learning · Computer Science 2020-07-15 Jean-Baptiste Tristan , Joseph Tassarotti , Koundinya Vajjha , Michael L. Wick , Anindya Banerjee

This paper surveys the analysis of parametric Markov models whose transitions are labelled with functions over a finite set of parameters. These models are symbolic representations of uncountable many concrete probabilistic models, each…

Logic in Computer Science · Computer Science 2022-07-15 Nils Jansen , Sebastian Junges , Joost-Pieter Katoen

The goal of this paper is to analyze distributional Markov Decision Processes as a class of control problems in which the objective is to learn policies that steer the distribution of a cumulative reward toward a prescribed target law,…

Optimization and Control · Mathematics 2026-02-09 Nicole Bäuerle , Athanasios Vasileiadis