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Goal-oriented de novo molecule design, namely generating molecules with specific property or substructure constraints, is a crucial yet challenging task in drug discovery. Existing methods, such as Bayesian optimization and reinforcement…

Computational Engineering, Finance, and Science · Computer Science 2025-02-28 Chuanliu Fan , Ziqiang Cao , Zicheng Ma , Nan Yu , Yimin Peng , Jun Zhang , Yiqin Gao , Guohong Fu

Automatic music captioning, which generates natural language descriptions for given music tracks, holds significant potential for enhancing the understanding and organization of large volumes of musical data. Despite its importance,…

Sound · Computer Science 2023-08-01 SeungHeon Doh , Keunwoo Choi , Jongpil Lee , Juhan Nam

Large language models (LLMs) process and predict sequences containing text to answer questions, and address tasks including document summarization, providing recommendations, writing software and solving quantitative problems. We provide a…

Numerical Analysis · Mathematics 2026-02-02 Ricardo Baptista , Andrew Stuart , Son Tran

There is a compelling necessity from enterprises for fine tuning LLMs (Large Language Models) o get them trained on proprietary domain knowledge. The challenge is to imbibe the LLMs with domain specific knowledge using the most optimial…

Software Engineering · Computer Science 2024-04-18 Mathav Raj J , Kushala VM , Harikrishna Warrier , Yogesh Gupta

Large language models have emerged as a promising approach towards achieving general-purpose AI agents. The thriving open-source LLM community has greatly accelerated the development of agents that support human-machine dialogue interaction…

Computer Vision and Pattern Recognition · Computer Science 2023-11-07 Zhenfei Yin , Jiong Wang , Jianjian Cao , Zhelun Shi , Dingning Liu , Mukai Li , Lu Sheng , Lei Bai , Xiaoshui Huang , Zhiyong Wang , Jing Shao , Wanli Ouyang

Multimodal Large Language Models (MLLMs) have experienced significant advancements recently. Nevertheless, challenges persist in the accurate recognition and comprehension of intricate details within high-resolution images. Despite being…

Computer Vision and Pattern Recognition · Computer Science 2024-03-05 Haogeng Liu , Quanzeng You , Xiaotian Han , Yiqi Wang , Bohan Zhai , Yongfei Liu , Yunzhe Tao , Huaibo Huang , Ran He , Hongxia Yang

Recovering Computer-Aided Design (CAD) programs from 3D geometries is a widely studied problem. Recent advances in large language models (LLMs) have enabled progress in CAD program synthesis, but existing methods rely on supervised training…

Computer Vision and Pattern Recognition · Computer Science 2026-02-16 Yuanbo Li , Dule Shu , Yanying Chen , Matt Klenk , Daniel Ritchie

The proliferation of complex structured data in hybrid sources, such as PDF documents and web pages, presents unique challenges for current Large Language Models (LLMs) and Multi-modal Large Language Models (MLLMs) in providing accurate…

Information Retrieval · Computer Science 2025-08-22 Shivani Upadhyay , Messiah Ataey , Syed Shariyar Murtaza , Yifan Nie , Jimmy Lin

Patents play a critical role in driving technological innovation by granting inventors exclusive rights to their inventions. However the process of drafting a patent application is often expensive and time-consuming, making it a prime…

Computation and Language · Computer Science 2025-09-25 Ryan Shea , Zhou Yu

Multimodal Large Language Models (MLLMs) have shown impressive capabilities in image understanding and generation. However, current benchmarks fail to accurately evaluate the chart comprehension of MLLMs due to limited chart types and…

Computer Vision and Pattern Recognition · Computer Science 2024-06-21 Zhengzhuo Xu , Sinan Du , Yiyan Qi , Chengjin Xu , Chun Yuan , Jian Guo

We propose DISC-LawLLM, an intelligent legal system utilizing large language models (LLMs) to provide a wide range of legal services. We adopt legal syllogism prompting strategies to construct supervised fine-tuning datasets in the Chinese…

Computation and Language · Computer Science 2023-09-26 Shengbin Yue , Wei Chen , Siyuan Wang , Bingxuan Li , Chenchen Shen , Shujun Liu , Yuxuan Zhou , Yao Xiao , Song Yun , Xuanjing Huang , Zhongyu Wei

Recent advancements in implicit 3D representations and generative models have markedly propelled the field of 3D object generation forward. However, it remains a significant challenge to accurately model geometries with defined sharp…

Graphics · Computer Science 2024-01-17 Zeqing Yuan , Haoxuan Lan , Qiang Zou , Junbo Zhao

Due to their architecture and vast pre-training data, large language models (LLMs) demonstrate strong text classification performance. However, LLM output - here, the category assigned to a text - depends heavily on the wording of the…

Computation and Language · Computer Science 2025-12-04 Kylie L. Anglin , Stephanie Milan , Brittney Hernandez , Claudia Ventura

The parallels between protein sequences and natural language in their sequential structures have inspired the application of large language models (LLMs) to protein understanding. Despite the success of LLMs in NLP, their effectiveness in…

Quantitative Methods · Quantitative Biology 2024-07-09 Yiqing Shen , Zan Chen , Michail Mamalakis , Luhan He , Haiyang Xia , Tianbin Li , Yanzhou Su , Junjun He , Yu Guang Wang

Large language models (LLMs) have been effectively used for many computer vision tasks, including image classification. In this paper, we present a simple yet effective approach for zero-shot image classification using multimodal LLMs.…

Computer Vision and Pattern Recognition · Computer Science 2025-06-27 Abdelrahman Abdelhamed , Mahmoud Afifi , Alec Go

This paper presents GPSM4K, a comprehensive geometry multimodal dataset tailored to augment the problem-solving capabilities of Large Vision Language Models (LVLMs). GPSM4K encompasses 2157 multimodal question-answer pairs manually…

In contrast to their remarkable performance on general knowledge QA, the true abilities of Large Language Models (LLMs) in tasks demanding deep, specialized reasoning, such as in protein biology, have yet to be thoroughly investigated.…

Quantitative Methods · Quantitative Biology 2025-12-30 Dingyi Rong , Zijian Chen , Qi Jia , Kaiwei Zhang , Haotian Lu , Guangtao Zhai , Ning Liu

Printed-Circuit-board (PCB) footprint geometry labeling of integrated circuits (IC) is essential in defining the physical interface between components and the PCB layout, requiring exceptional visual perception proficiency. However, due to…

Computer Vision and Pattern Recognition · Computer Science 2025-08-07 Yida Wang , Taiting Lu , Runze Liu , Lanqing Yang , Yifan Yang , Zhe Chen , Yuehai Wang , Yixin Liu , Kaiyuan Lin , Xiaomeng Chen , Dian Ding , Yijie Li , Yi-Chao Chen , Yincheng Jin , Mahanth Gowda

Discrete tokenizers have emerged as indispensable components in modern machine learning systems, particularly within the context of autoregressive modeling and large language models (LLMs). These tokenizers serve as the critical interface…

Information Retrieval · Computer Science 2025-02-19 Jian Jia , Jingtong Gao , Ben Xue , Junhao Wang , Qingpeng Cai , Quan Chen , Xiangyu Zhao , Peng Jiang , Kun Gai

Vision Language Models (VLMs) like CLIP have attracted substantial attention in pathology, serving as backbones for applications such as zero-shot image classification and Whole Slide Image (WSI) analysis. Additionally, they can function as…

Computer Vision and Pattern Recognition · Computer Science 2024-07-02 Yuxuan Sun , Yunlong Zhang , Yixuan Si , Chenglu Zhu , Zhongyi Shui , Kai Zhang , Jingxiong Li , Xingheng Lyu , Tao Lin , Lin Yang
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