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We present a Bayesian inversion-based digital twin that employs acoustic pressure data from seafloor sensors, along with 3D coupled acoustic-gravity wave equations, to infer earthquake-induced spatiotemporal seafloor motion in real time and…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-12-09 Stefan Henneking , Sreeram Venkat , Veselin Dobrev , John Camier , Tzanio Kolev , Milinda Fernando , Alice-Agnes Gabriel , Omar Ghattas

Real-time tsunami early warning relies on distributed sensor networks to infer seismic sources and seafloor motion. Optimizing these networks via Bayesian optimal experimental design (OED) is exceptionally challenging for systems governed…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-04-13 Sreeram Venkat , Stefan Henneking , Omar Ghattas

Digital twins are transforming engineering and applied sciences by enabling real-time monitoring, simulation, and predictive analysis of physical systems and processes. However, conventional digital twins rely primarily on passive data…

Computational Engineering, Finance, and Science · Computer Science 2026-03-31 Matteo Torzoni , Domenico Maisto , Andrea Manzoni , Francesco Donnarumma , Giovanni Pezzulo , Alberto Corigliano

Digital Twins, virtual replicas of physical systems that enable real-time monitoring, model updates, predictions, and decision-making, present novel avenues for proactive control strategies for autonomous systems. However, achieving…

Systems and Control · Electrical Eng. & Systems 2025-05-08 Yi-Ping Chen , Ying-Kuan Tsai , Vispi Karkaria , Wei Chen

The digital twin concept represents an appealing opportunity to advance condition-based and predictive maintenance paradigms for civil engineering systems, thus allowing reduced lifecycle costs, increased system safety, and increased system…

Numerical Analysis · Mathematics 2023-11-10 Matteo Torzoni , Marco Tezzele , Stefano Mariani , Andrea Manzoni , Karen E. Willcox

This paper presents a novel framework for goal-oriented optimal static sensor placement and dynamic sensor steering in PDE-constrained inverse problems, utilizing a Bayesian approach accelerated by low-rank approximations. The framework is…

Numerical Analysis · Mathematics 2025-07-09 Marco Mattuschka , Noah An der Lan , Max von Danwitz , Daniel Wolff , Alexander Popp

This work presents a probabilistic digital twin framework for response prediction in dynamical systems governed by misspecified physics. The approach integrates Gaussian Process Latent Force Models (GPLFM) and Bayesian Neural Networks…

Machine Learning · Computer Science 2025-12-01 Sahil Kashyap , Rajdip Nayek

This paper presents a proof-of-concept digital twin framework for simulation-driven diabetes modeling using benchmark clinical data, synthetic temporal augmentation, and illustrative continuous glucose monitoring (CGM) analysis. Unlike…

Machine Learning · Computer Science 2026-05-13 Zarrin Monirzadeh

Over the past decade, scientific machine learning has transformed the development of mathematical and computational frameworks for analyzing, modeling, and predicting complex systems. From inverse problems to numerical PDEs, dynamical…

Machine Learning · Computer Science 2025-09-26 Matthias Chung , Deepanshu Verma , Max Collins , Amit N. Subrahmanya , Varuni Katti Sastry , Vishwas Rao

The concept of creating a virtual copy of a complete Cyber-Physical System opens up numerous possibilities, including real-time assessments of the physical environment and continuous learning from the system to provide reliable and precise…

Artificial Intelligence · Computer Science 2023-11-22 Carine Menezes Rebello , Johannes Jäschkea , Idelfonso B. R. Nogueira

Digital twins are virtual systems designed to predict how a real-world process will evolve in response to interventions. This modelling paradigm holds substantial promise in many applications, but rigorous procedures for assessing their…

Methodology · Statistics 2023-11-03 Rob Cornish , Muhammad Faaiz Taufiq , Arnaud Doucet , Chris Holmes

In this paper, a hyperparameter tuning based Bayesian optimization of digital twins is carried out to diagnose various faults in grid connected inverters. As fault detection and diagnosis require very high precision, we channelize our…

Systems and Control · Electrical Eng. & Systems 2022-12-08 Pavol Mulinka , Subham Sahoo , Charalampos Kalalas , Pedro H. J. Nardelli

This work shows how adaptivity can enhance value realization of digital twins in civil engineering. We focus on adapting the state transition models within digital twins represented through probabilistic graphical models. The bi-directional…

Machine Learning · Computer Science 2026-05-12 Eugenio Varetti , Matteo Torzoni , Marco Tezzele , Andrea Manzoni

The development of Digital Twins (DTs) represents a transformative advance for simulating and optimizing complex systems in a controlled digital space. Despite their potential, the challenge of constructing DTs that accurately replicate and…

Systems and Control · Electrical Eng. & Systems 2024-06-21 Longfei Ma , Nan Cheng , Xiucheng Wang , Jiong Chen , Yinjun Gao , Dongxiao Zhang , Jun-Jie Zhang

Quantifying the uncertainty in predictive models is critical for establishing trust and enabling risk-informed decision making for personalized medicine. In contrast to one-size-fits-all approaches that seek to mitigate risk at the…

Computational Engineering, Finance, and Science · Computer Science 2025-05-15 Graham Pash , Umberto Villa , David A. Hormuth , Thomas E. Yankeelov , Karen Willcox

Commonly adopted in the manufacturing and aerospace sectors, digital twin (DT) platforms are increasingly seen as a promising paradigm to control, monitor, and analyze software-based, "open", communication systems. Notably, DT platforms…

Signal Processing · Electrical Eng. & Systems 2023-08-30 Clement Ruah , Osvaldo Simeone , Bashir Al-Hashimi

We present a computational framework for estimating the uncertainty in the numerical solution of linearized infinite-dimensional statistical inverse problems. We adopt the Bayesian inference formulation: given observational data and their…

Numerical Analysis · Mathematics 2013-08-07 Tan Bui-Thanh , Omar Ghattas , James Martin , Georg Stadler

We articulate the design imperatives for machine-learning based digital twins for nonlinear dynamical systems subject to external driving, which can be used to monitor the ``health'' of the target system and anticipate its future collapse.…

Adaptation and Self-Organizing Systems · Physics 2022-10-13 Ling-Wei Kong , Yang Weng , Bryan Glaz , Mulugeta Haile , Ying-Cheng Lai

Effective real-time monitoring is a foundation of digital twin technology, crucial for detecting material degradation and maintaining the structural integrity of nuclear systems to ensure both safety and operational efficiency. Traditional…

Machine Learning · Computer Science 2024-12-02 Raisa Bentay Hossain , Farid Ahmed , Kazuma Kobayashi , Seid Koric , Diab Abueidda , Syed Bahauddin Alam

A digital twin is a virtual replica of a real-world physical phenomena that uses mathematical modeling to characterize and simulate its defining features. By constructing digital twins for disease processes, we can perform in-silico…

Machine Learning · Computer Science 2024-11-04 Keying Kuang , Frances Dean , Jack B. Jedlicki , David Ouyang , Anthony Philippakis , David Sontag , Ahmed M. Alaa
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