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Spatial transcriptomics studies are becoming increasingly large and commonplace, necessitating simultaneous analysis of a large number of spatially resolved variables. Correspondingly, a diverse range of methodologies have been proposed to…

Quantitative Methods · Quantitative Biology 2025-09-09 James Boyle , Gregory Hamm , Eleanor Williams , Robin JG Hartman , Magnus Soderburg , Ian Henry , Michael Casey

We study the persistent homology of both functional data on compact topological spaces and structural data presented as compact metric measure spaces. One of our goals is to define persistent homology so as to capture primarily properties…

Algebraic Topology · Mathematics 2018-11-27 Haibin Hang , Facundo Mémoli , Washington Mio

We introduce a consistent estimator for the homology (an algebraic structure representing connected components and cycles) of level sets of both density and regression functions. Our method is based on kernel estimation. We apply this…

Statistics Theory · Mathematics 2016-09-30 Omer Bobrowski , Sayan Mukherjee , Jonathan E. Taylor

Sparse systems are usually parameterized by a tuning parameter that determines the sparsity of the system. How to choose the right tuning parameter is a fundamental and difficult problem in learning the sparse system. In this paper, by…

Methodology · Statistics 2019-01-18 Moo K. Chung , Jamie L. Hanson , Jieping Ye , Richard J. Davidson , Seth D. Pollak

Persistent homology is a popular and useful tool for analysing finite metric spaces, revealing features that can be used to distinguish sets of unlabeled points and as input into machine learning pipelines. The famous stability theorem of…

Computational Geometry · Computer Science 2024-05-10 Philip Smith , Vitaliy Kurlin

Topological data analysis (TDA) is a rapidly developing collection of methods for studying the shape of point cloud and other data types. One popular approach, designed to be robust to noise and outliers, is to first use a smoothing…

Methodology · Statistics 2017-12-27 Chul Moon , Noah Giansiracusa , Nicole A. Lazar

A suitable feature representation that can both preserve the data intrinsic information and reduce data complexity and dimensionality is key to the performance of machine learning models. Deeply rooted in algebraic topology, persistent…

Algebraic Topology · Mathematics 2018-11-02 Chi Seng Pun , Kelin Xia , Si Xian Lee

Phase separation mechanisms can produce a variety of complicated and intricate microstructures, which often can be difficult to characterize in a quantitative way. In recent years, a number of novel topological metrics for microstructures…

Numerical Analysis · Mathematics 2020-05-29 Paweł Dłotko , Thomas Wanner

Network centrality measures play a crucial role in understanding graph structures, assessing the importance of nodes, paths, or cycles based on directed or reciprocal interactions encoded by vertices and edges. Estrada and Ross extended…

Computational Geometry · Computer Science 2024-04-26 John Rick D. Manzanares , Paul Samuel P. Ignacio

Topological data analysis provides a multiscale description of the geometry and topology of quantitative data. The persistence landscape is a topological summary that can be easily combined with tools from statistics and machine learning.…

Computational Geometry · Computer Science 2017-07-21 Peter Bubenik , Pawel Dlotko

Biological and physical systems often exhibit distinct structures at different spatial/temporal scales. Persistent homology is an algebraic tool that provides a mathematical framework for analyzing the multi-scale structures frequently…

Algebraic Topology · Mathematics 2016-02-01 Jonathan Jaquette , Miroslav Kramár

Persistent homology is a tool from Topological Data Analysis (TDA) used to summarize the topology underlying data. It can be conveniently represented through persistence diagrams. Observing a noisy signal, common strategies to infer its…

Statistics Theory · Mathematics 2024-08-28 Hugo Henneuse

Persistent homology is an important methodology in topological data analysis which adapts theory from algebraic topology to data settings. Computing persistent homology produces persistence diagrams, which have been successfully used in…

Machine Learning · Statistics 2026-01-13 Yueqi Cao , Anthea Monod

This article studies the robust version of persistent homology based on trimming methodology to capture the geometric feature through support of the data in presence of outliers. Precisely speaking, the proposed methodology works when the…

Methodology · Statistics 2026-01-01 Tuhin Subhra Mahato , Subhra Sankar Dhar

Data quality is crucial for the successful training, generalization and performance of machine learning models. We propose to measure the quality of a subset concerning the dataset it represents, using topological data analysis techniques.…

Algebraic Topology · Mathematics 2024-10-01 Álvaro Torras-Casas , Eduardo Paluzo-Hidalgo , Rocio Gonzalez-Diaz

The theory of multidimensional persistent homology was initially developed in the discrete setting, and involved the study of simplicial complexes filtered through an ordering of the simplices. Later, stability properties of…

Computational Geometry · Computer Science 2013-03-28 Niccolò Cavazza , Marc Ethier , Patrizio Frosini , Tomasz Kaczynski , Claudia Landi

Single-parameter persistent homology, a key tool in topological data analysis, has been widely applied to data problems along with statistical techniques that quantify the significance of the results. In contrast, statistical techniques for…

Algebraic Topology · Mathematics 2020-12-14 Matthew Wright , Xiaojun Zheng

In this article we propose a novel approach for comparing the persistent homology representations of two spaces (filtrations). Commonly used methods are based on numerical summaries such as persistence diagrams and persistence landscapes,…

Machine Learning · Computer Science 2021-01-05 Yohai Reani , Omer Bobrowski

Using persistent homology to guide optimization has emerged as a novel application of topological data analysis. Existing methods treat persistence calculation as a black box and backpropagate gradients only onto the simplices involved in…

Computational Geometry · Computer Science 2023-11-06 Arnur Nigmetov , Dmitriy Morozov

High-quality training data is the foundation of machine learning and artificial intelligence, shaping how models learn and perform. Although much is known about what types of data are effective for training, the impact of the data's…

Machine Learning · Computer Science 2025-10-21 Yang Ba , Mohammad Sadeq Abolhasani , Rong Pan