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Large language models (LLMs) hold great promise in summarizing medical evidence. Most recent studies focus on the application of proprietary LLMs. Using proprietary LLMs introduces multiple risk factors, including a lack of transparency and…

Identifying medication discontinuations in electronic health records (EHRs) is vital for patient safety but is often hindered by information being buried in unstructured notes. This study aims to evaluate the capabilities of advanced…

Computation and Language · Computer Science 2025-11-10 Chong Shao , Douglas Snyder , Chiran Li , Bowen Gu , Kerry Ngan , Chun-Ting Yang , Jiageng Wu , Richard Wyss , Kueiyu Joshua Lin , Jie Yang

The recent success of large language models (LLMs) has paved the way for their adoption in the high-stakes domain of healthcare. Specifically, the application of LLMs in patient-trial matching, which involves assessing patient eligibility…

Artificial Intelligence · Computer Science 2023-12-18 Mauro Nievas , Aditya Basu , Yanshan Wang , Hrituraj Singh

Physician burnout in the United States has reached critical levels, driven in part by the administrative burden of Electronic Health Record (EHR) documentation and complex diagnostic codes. To relieve this strain and maintain strict patient…

Information Retrieval · Computer Science 2026-03-25 Peter Hartnett , Chung-Chi Huang , Sarah Hartnett , David Hartnett

Clinical notes are often stored in unstructured or semi-structured formats after extraction from electronic medical record (EMR) systems, which complicates their use for secondary analysis and downstream clinical applications. Reliable…

Computation and Language · Computer Science 2025-12-30 Risha Surana , Adrian Law , Sunwoo Kim , Rishab Sridhar , Angxiao Han , Peiyu Hong

Proprietary Large Language Models (LLMs) such as GPT-4 and Gemini have demonstrated promising capabilities in clinical text summarization tasks. However, due to patient data privacy concerns and computational costs, many healthcare…

Fine-tuning on open-source Large Language Models (LLMs) with proprietary data is now a standard practice for downstream developers to obtain task-specific LLMs. Surprisingly, we reveal a new and concerning risk along with the practice: the…

Computation and Language · Computer Science 2026-04-06 Zhexin Zhang , Yuhao Sun , Junxiao Yang , Shiyao Cui , Yuanchao Zhang , Hongning Wang , Minlie Huang

Background: Clinical documentation represents a significant burden for healthcare providers, with physicians spending up to 2 hours daily on administrative tasks. Recent advances in large language models (LLMs) offer promising solutions,…

Computation and Language · Computer Science 2025-07-08 Johnson Thomas , Ayush Mudgal , Wendao Liu , Nisten Tahiraj , Zeeshaan Mohammed , Dhruv Diddi

Objective: Develop a cost-effective, large language model (LLM)-based pipeline for automatically extracting Review of Systems (ROS) entities from clinical notes. Materials and Methods: The pipeline extracts ROS section from the clinical…

Computation and Language · Computer Science 2026-05-15 Hieu Nghiem , Zhuqi Miao , Hemanth Reddy Singareddy , Jivan Lamichhane , Abdulaziz Ahmed , Johnson Thomas , Dursun Delen , William Paiva

Large Language Models (LLMs) are distinguished by their architecture, which dictates their parameter size and performance capabilities. Social scientists have increasingly adopted LLMs for text classification tasks, which are difficult to…

Computation and Language · Computer Science 2024-11-05 Marcello Carammia , Stefano Maria Iacus , Giuseppe Porro

Medical reports contain rich clinical information but are often unstructured and written in domain-specific language, posing challenges for information extraction. While proprietary large language models (LLMs) have shown promise in…

Computation and Language · Computer Science 2026-03-12 Luc Builtjes , Joeran Bosma , Mathias Prokop , Bram van Ginneken , Alessa Hering

Europe's healthcare systems require enhanced interoperability and digitalization, driving a demand for innovative solutions to process legacy clinical data. This paper presents the results of our project, which aims to leverage Large…

Computation and Language · Computer Science 2025-07-09 Aynur Guluzade , Naguib Heiba , Zeyd Boukhers , Florim Hamiti , Jahid Hasan Polash , Yehya Mohamad , Carlos A Velasco

Unstructured text in medical notes and dialogues contains rich information. Recent advancements in Large Language Models (LLMs) have demonstrated superior performance in question answering and summarization tasks on unstructured text data,…

Computation and Language · Computer Science 2024-05-31 Yuhao Chen , Zhimu Wang , Bo Wen , Farhana Zulkernine

Background: Structured information extraction from unstructured histopathology reports facilitates data accessibility for clinical research. Manual extraction by experts is time-consuming and expensive, limiting scalability. Large language…

Effective clinical history taking is a foundational yet underexplored component of clinical reasoning. While large language models (LLMs) have shown promise on static benchmarks, they often fall short in dynamic, multi-turn diagnostic…

Computation and Language · Computer Science 2026-01-30 Yang Zhou , Zhenting Sheng , Mingrui Tan , Yuting Song , Jun Zhou , Yu Heng Kwan , Lian Leng Low , Yang Bai , Yong Liu

Large language models (LLMs) such as GPT-4o and o1 have demonstrated strong performance on clinical natural language processing (NLP) tasks across multiple medical benchmarks. Nonetheless, two high-impact NLP tasks - structured tabular…

The rapid growth of biomedical literature poses challenges for manual knowledge curation and synthesis. Biomedical Natural Language Processing (BioNLP) automates the process. While Large Language Models (LLMs) have shown promise in general…

The unstructured nature of clinical notes within electronic health records often conceals vital patient-related information, making it challenging to access or interpret. To uncover this hidden information, specialized Natural Language…

Extracting medical history entities (MHEs) related to a patient's chief complaint (CC), history of present illness (HPI), and past, family, and social history (PFSH) helps structure free-text clinical notes into standardized EHRs,…

Computation and Language · Computer Science 2025-04-01 Hieu Nghiem , Tuan-Dung Le , Suhao Chen , Thanh Thieu , Andrew Gin , Ellie Phuong Nguyen , Dursun Delen , Johnson Thomas , Jivan Lamichhane , Zhuqi Miao

Natural language processing (NLP) is a key technology to extract important patient information from clinical narratives to support healthcare applications. The rapid development of large language models (LLMs) has revolutionized many NLP…

Computation and Language · Computer Science 2025-09-08 Cheng Peng , Xinyu Dong , Mengxian Lyu , Daniel Paredes , Yaoyun Zhang , Yonghui Wu
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