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The vast separation dividing the characteristic times of energy confinement and turbulence in the core of toroidal plasmas makes first-principles prediction on long timescales extremely challenging. Here we report the demonstration of a…

Cell motility is fundamental to many biological processes, and cells exhibit a variety of migration patterns. Many motile cell types follow a universal law that connects their speed and persistency, a property that can originate from the…

Active gels are a class of biologically-relevant material containing embedded agents that spontaneously generate forces acting on a sparse filament network. In vitro experiments of protein filaments and molecular motors have revealed a…

Soft Condensed Matter · Physics 2024-06-03 David A. Head , Gerhard Gompper , W. J. Briels

During the progression of pulmonary fibrosis, initially isolated regions of high stiffness form and grow in the lung tissue due to collagen deposition by fibroblast cells. We have previously shown that ongoing collagen deposition may not…

Biological Physics · Physics 2014-07-15 Cláudio L. N. Oliveira , Jason H. T. Bates , Béla Suki

Cell-cell adhesion plays a vital role in the development and maintenance of multicellular organisms. One of its functions is regulation of cell migration, such as occurs, e.g. during embryogenesis or in cancer. In this work, we develop a…

Tissues and Organs · Quantitative Biology 2024-03-08 Anna Zhigun , Mabel Lizzy Rajendran

We study dispersive models of fluid flow in viscoelastic vessels, derived in the study of blood flow. The unknowns in the models are the velocity of the fluid in the axial direction and the displacement of the vessel wall from rest. We…

Analysis of PDEs · Mathematics 2022-11-23 Hyeju Kim , David M. Ambrose

We show that hydrodynamic theories of polar active matter generically possess inhomogeneous traveling solutions. We introduce a unifying dynamical-system framework to establish the shape of these intrinsically nonlinear patterns, and show…

Although collective cell migration (CCM) is a highly coordinated and fine-tuned migratory mode, instabilities in the form of cell swirling motion (CSM) often occur. The CSM represents a product of the active turbulence obtained at low…

Tissues and Organs · Quantitative Biology 2021-11-01 Ivana Pajic-Lijakovic , Milan Milivojevic

We characterize cell motion in experiments and show that the transition to collective motion in colonies of gliding bacterial cells confined to a monolayer appears through the organization of cells into larger moving clusters. Collective…

Cell-cell adhesion is widely hypothesised to maintain cohesion within the long streams of follower cells that trail leader subpopulations during collective migration, including in neural crest cell migration, angiogenesis, and cancer cell…

Cell Behavior · Quantitative Biology 2026-04-17 Thomas Jun Jewell , Samuel W. S. Johnson , Ruth E. Baker , Philip K. Maini

When particles move at a constant speed and have the tendency to align their directions of motion, ordered large scale movement can emerge despite significant levels of noise. Many variants of this model of self-propelled particles have…

Biological Physics · Physics 2012-12-11 Matthias Meschede , Oskar Hallatschek

Epithelial cell clusters often move collectively on a substrate. Mechanical signals play a major role in organizing this behavior. There are a number of experimental observations in these systems which await a comprehensive explanation.…

Biological Physics · Physics 2021-01-22 Youyuan Deng , Herbert Levine , Xiaoming Mao , Leonard M. Sander

In this paper we consider the possibility of the stable migration of the single vibron excitation in the system consisting of biomolecule and the attached molecular structure. The model is based on the assumption of the vibron self-trapping…

Mesoscale and Nanoscale Physics · Physics 2024-10-07 Dalibor Chevizovich , Slobodanka Galovic , Vasilije Matic , Sergei Eh. Shirmovsky , Denis V. Shulga , Alexei V. Chizhov

We analyze the dynamics of crystal surfaces in the presence of electromigration. From a phase field model with a migration force which depends on the local geometry, we derive a step model with additional contributions in the kinetic…

Statistical Mechanics · Physics 2009-11-11 O. Pierre-Louis

Most of us must have been fascinated by the eye catching displays of collectively moving animals. Schools of fish can move in a rather orderly fashion and then change direction amazingly abruptly. There are a huge number of further examples…

Biological Physics · Physics 2011-01-13 K. Bhattacharya , Tamás Vicsek

We consider motility of keratocyte cells driven by myosin contraction and introduce a 2D free boundary model for such motion. This model generalizes a 1D model from [12] by combining a 2D Keller-Segel model and a Hele-Shaw type boundary…

Biological Physics · Physics 2022-02-23 C. Alex Safsten , Volodymyr Rybalko , Leonid Berlyand

Collective motion of cells is critical to some of the most vital tasks including wound healing, development, and immune response [Friedl and Gilmour 2009; Tokarski et al. 2012; Lee et al. 2012; Beltman et al. 2009], and is common to many…

Cell Behavior · Quantitative Biology 2014-07-04 Mircea Davidescu , Iain Couzin

The cytoskeleton in eukaryotic cells plays several crucial roles. In terms of intracellular transport, motor proteins use the cytoskeletal filaments as a backbone along which they can actively transport biological cargos such as vesicles…

Biological Physics · Physics 2020-06-20 Adélaïde Raguin , Norbert Kern , Andrea Parmeggiani

We study a non-linear and non-local evolution equation for curves obtained as the sharp interface limit of a phase-field model for crawling motion of eukaryotic cells on a substrate. We establish uniqueness of solutions to the sharp…

Analysis of PDEs · Mathematics 2017-03-03 Matthew S. Mizuhara , Peng Zhang

The dynamics of single cell migration on flat surfaces is usually modeled by a Langevin-like problem consisting of ballistic motion for short periods and random walk. for long periods. Conversely, recent studies have revealed a previously…