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Capturing molecular knowledge with representation learning approaches holds significant potential in vast scientific fields such as chemistry and life science. An effective and generalizable molecular representation is expected to capture…

Machine Learning · Computer Science 2024-06-17 Yizhen Luo , Kai Yang , Massimo Hong , Xing Yi Liu , Zikun Nie , Hao Zhou , Zaiqing Nie

Predicting patient features from single-cell data can help identify cellular states implicated in health and disease. Linear models and average cell type expressions are typically favored for this task for their efficiency and robustness,…

Machine Learning · Computer Science 2024-03-11 Jan P. Engelmann , Alessandro Palma , Jakub M. Tomczak , Fabian J. Theis , Francesco Paolo Casale

A novel two-phase molecule inference framework, mol-infer, has recently been developed to infer chemical graphs with prescribed abstract structures and desired property values through mixed integer linear programming (MILP) under the…

Quantitative Methods · Quantitative Biology 2026-05-29 Jianshen Zhu , Raveena Rai , Taiyo Sohkawa , Naveed Ahmed Azam , Kazuya Haraguchi , Liang Zhao , Tatsuya Akutsu

We present a hierarchical neural message passing architecture for learning on molecular graphs. Our model takes in two complementary graph representations: the raw molecular graph representation and its associated junction tree, where nodes…

Machine Learning · Computer Science 2020-06-23 Matthias Fey , Jan-Gin Yuen , Frank Weichert

The key challenge in unaligned multimodal language sequences lies in effectively integrating information from various modalities to obtain a refined multimodal joint representation. Recently, the disentangle and fuse methods have achieved…

Computation and Language · Computer Science 2024-09-20 Fan Qian , Jiqing Han , Jianchen Li , Yongjun He , Tieran Zheng , Guibin Zheng

Molecule-and-text cross-modal representation learning has emerged as a promising direction for enhancing the quality of molecular representation, thereby improving performance in various scientific fields. However, most approaches employ a…

Quantitative Methods · Quantitative Biology 2025-03-04 Yikun Zhang , Geyan Ye , Chaohao Yuan , Bo Han , Long-Kai Huang , Jianhua Yao , Wei Liu , Yu Rong

Machine-learning of atomic-scale properties amounts to extracting correlations between structure, composition and the quantity that one wants to predict. Representing the input structure in a way that best reflects such correlations makes…

Chemical Physics · Physics 2021-02-02 Michael J. Willatt , Félix Musil , Michele Ceriotti

Machine learning representations of many-body quantum states have recently been introduced as an ansatz to describe the ground states and unitary evolutions of many-body quantum systems. We explore one of the most important representations,…

Quantum Physics · Physics 2019-01-10 Zhih-Ahn Jia , Yuan-Hang Zhang , Yu-Chun Wu , Liang Kong , Guang-Can Guo , Guo-Ping Guo

A new spectrum generating algebra for a unified description of rotations and vibrations in polyatomic molecules is introduced. An application to nonlinear X$_3$ molecules shows that this model (i) incorporates exactly the relevant point…

chem-ph · Physics 2009-10-28 R. Bijker , A. E. L. Dieperink , A. Leviatan

We review the current state of automatic differentiation (AD) for array programming in machine learning (ML), including the different approaches such as operator overloading (OO) and source transformation (ST) used for AD, graph-based…

Machine Learning · Computer Science 2019-01-04 Bart van Merriënboer , Olivier Breuleux , Arnaud Bergeron , Pascal Lamblin

This paper introduces a new representation method that is mainly based on chemical bonds among atoms in materials. Each chemical bond and its surrounded atoms are considered as a unified unit or a local structure that is expected to reflect…

Materials Science · Physics 2018-01-03 Van-Doan Nguyen , Le Dinh Khiet , Pham Tien Lam , Dam Hieu Chi

Ophthalmologists typically require multimodal data sources to improve diagnostic accuracy in clinical decisions. However, due to medical device shortages, low-quality data and data privacy concerns, missing data modalities are common in…

Computer Vision and Pattern Recognition · Computer Science 2025-02-18 Chengzhi Liu , Zile Huang , Zhe Chen , Feilong Tang , Yu Tian , Zhongxing Xu , Zihong Luo , Yalin Zheng , Yanda Meng

Despite their importance in a wide variety of applications, the estimation of ionization cross sections for large molecules continues to present challenges for both experiment and theory. Machine learning algorithms have been shown to be an…

Atomic Physics · Physics 2024-11-25 A. L. Harris , J. Nepomuceno

Implicit neural representations have emerged as a powerful tool in learning 3D geometry, offering unparalleled advantages over conventional representations like mesh-based methods. A common type of INR implicitly encodes a shape's boundary…

Computer Vision and Pattern Recognition · Computer Science 2024-10-17 Shen Fan , Przemyslaw Musialski

This paper proposes a machine learning (ML) method to predict stable molecular geometries from their chemical composition. The method is useful for generating molecular conformations which may serve as initial geometries for saving time…

Machine learning interatomic potentials (MLIPs) enables molecular dynamics (MD) simulations with ab initio accuracy and has been applied to various fields of physical science. However, the performance and transferability of MLIPs are…

Chemical Physics · Physics 2024-04-16 Taoyong Cui , Chenyu Tang , Mao Su , Shufei Zhang , Yuqiang Li , Lei Bai , Yuhan Dong , Xingao Gong , Wanli Ouyang

Recent advances in machine learning (ML) have expedited materials discovery and design. One significant challenge faced in ML for materials is the expansive combinatorial space of potential materials formed by diverse constituents and their…

Machine Learning · Computer Science 2024-06-13 Hengrui Zhang , Jie Chen , James M. Rondinelli , Wei Chen

Independently trained machine learning models tend to learn similar features. Given an ensemble of independently trained models, this results in correlated predictions and common failure modes. Previous attempts focusing on decorrelation of…

In deep metric learning (DML), high-level input data are represented in a lower-level representation (embedding) space, such that samples from the same class are mapped close together, while samples from disparate classes are mapped further…

Computer Vision and Pattern Recognition · Computer Science 2023-04-03 Ryan Furlong , Vincent O'Brien , James Garland , Daniel Palacios-Alonso , Francisco Dominguez-Mateos

Purpose: Large Language Models (LLMs) like GPT (Generative Pre-trained Transformer) from OpenAI and LLaMA (Large Language Model Meta AI) from Meta AI are increasingly recognized for their potential in the field of cheminformatics,…

Biomolecules · Quantitative Biology 2024-05-22 Shaghayegh Sadeghi , Alan Bui , Ali Forooghi , Jianguo Lu , Alioune Ngom