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The objective of this Philosophiae Doctor (Ph.D) thesis is to propose an efficient approach for optimizing a multidisciplinary black-box model when the optimization problem is constrained and involves a large number of mixed integer design…

Optimization and Control · Mathematics 2025-07-24 Paul Saves

Metal-organic frameworks (MOFs) are highly promising for carbon capture, yet navigating their vast design space remains challenging. Recent deep generative models enable de novo MOF design but primarily act as feed-forward structure…

Machine Learning · Computer Science 2026-04-16 Chaoran Zhang , Guangyao Li , Dongxu Ji

We consider the problem of optimizing combinatorial spaces (e.g., sequences, trees, and graphs) using expensive black-box function evaluations. For example, optimizing molecules for drug design using physical lab experiments. Bayesian…

Machine Learning · Computer Science 2022-02-07 Aryan Deshwal , Janardhan Rao Doppa

When applying Bayesian optimization (BO) to scientific workflow, a major yet often overlooked source of uncertainty is the task itself -- namely, what to optimize and how to evaluate it -- which can evolve as evidence accumulates. We…

Artificial Intelligence · Computer Science 2026-05-11 Masaki Adachi , Yuta Suzuki , Juliusz Ziomek

The problem of radio resource allocation for global energy efficiency (GEE) maximization in mmWaves large-scale multiple-input multiple-output (MIMO) systems using hybrid-beamforming with spatial modulation is addressed. The theoretical…

Information Theory · Computer Science 2018-06-14 Merve Yüzgeçcioğlu , Alessio Zappone , Eduard Jorswieck

The growth of low-altitude economy (LAE) has driven a rising demand for efficient and secure communication. However, conventional beamforming optimization techniques struggle in the complex LAE environments. In this context, generative…

Networking and Internet Architecture · Computer Science 2025-09-12 Geng Sun , Jia Qi , Chuang Zhang , Xuejie Liu , Jiacheng Wang , Dusit Niyato , Yuanwei Liu , Dong In Kim

One of the grand enduring goals of AI is to create generalist agents that can learn multiple different tasks from diverse data via multitask learning (MTL). However, in practice, applying gradient descent (GD) on the average loss across all…

Machine Learning · Computer Science 2023-10-31 Bo Liu , Yihao Feng , Peter Stone , Qiang Liu

Bayesian optimization (BO) is a powerful approach to sample-efficient optimization of black-box functions. However, in settings with very few function evaluations, a successful application of BO may require transferring information from…

Machine Learning · Computer Science 2024-09-10 Aryan Deshwal , Sait Cakmak , Yuhou Xia , David Eriksson

In offline multi-objective optimization (MOO), we leverage an offline dataset of designs and their associated labels to simultaneously minimize multiple objectives. This setting more closely mirrors complex real-world problems compared to…

Computational Engineering, Finance, and Science · Computer Science 2025-02-21 Ye Yuan , Can Chen , Christopher Pal , Xue Liu

Bayesian optimisation in the latent space of a Variational AutoEncoder (VAE) is a powerful framework for optimisation tasks over complex structured domains, such as the space of scientifically interesting molecules. However, existing…

Machine Learning · Computer Science 2025-07-08 Henry B. Moss , Sebastian W. Ober , Tom Diethe

We propose Intermediate Layer Optimization (ILO), a novel optimization algorithm for solving inverse problems with deep generative models. Instead of optimizing only over the initial latent code, we progressively change the input layer…

Machine Learning · Computer Science 2021-02-16 Giannis Daras , Joseph Dean , Ajil Jalal , Alexandros G. Dimakis

Holographic multiple-input multiple-output (HMIMO) is a potential technique for improving spectral efficiency (SE) while maintaining low hardware cost and power consumption. Although conventional alternating optimization (AO) methods are…

Signal Processing · Electrical Eng. & Systems 2026-01-29 Shiyong Chen , Shengqian Han

Robots have been used in all sorts of automation, and yet the design of robots remains mainly a manual task. We seek to provide design tools to automate the design of robots themselves. An important challenge in robot design automation is…

Robotics · Computer Science 2022-09-26 Jiaheng Hu , Julian Whiman , Howie Choset

Bayesian Optimization (BO) is a popular framework for optimizing black-box functions. Despite its effectiveness, BO is often inefficient for high-dimensional problems due to the exponential growth of the search space, heterogeneity of the…

Optimization and Control · Mathematics 2026-05-08 Sourav Das , Debjani Chakraborty , Pabitra Mitra

Bayesian optimization (BO) is widely adopted in black-box optimization problems and it relies on a surrogate model to approximate the black-box response function. With the increasing number of black-box optimization tasks solved and even…

Machine Learning · Computer Science 2023-08-10 Wenlong Lyu , Shoubo Hu , Jie Chuai , Zhitang Chen

Data-driven materials design often encounters challenges where systems require or possess qualitative (categorical) information. Metal-organic frameworks (MOFs) are an example of such material systems. The representation of MOFs through…

Materials Science · Physics 2023-11-16 Yigitcan Comlek , Thang Duc Pham , Randall Snurr , Wei Chen

In aerodynamic shape optimization, the convergence and computational cost are greatly affected by the representation capacity and compactness of the design space. Previous research has demonstrated that using a deep generative model to…

Machine Learning · Computer Science 2021-01-11 Wei Chen , Arun Ramamurthy

Finding the optimal design of a hydrodynamic or aerodynamic surface is often impossible due to the expense of evaluating the cost functions (say, with computational fluid dynamics) needed to determine the performances of the flows that the…

Computational Geometry · Computer Science 2022-11-15 Haris Moazam Sheikh , Tess A. Callan , Kealan J. Hennessy , Philip S. Marcus

Optimization of high-dimensional black-box functions is an extremely challenging problem. While Bayesian optimization has emerged as a popular approach for optimizing black-box functions, its applicability has been limited to…

Machine Learning · Statistics 2018-08-06 Zi Wang , Chengtao Li , Stefanie Jegelka , Pushmeet Kohli

Existing high-dimensional Bayesian optimization (BO) methods aim to overcome the curse of dimensionality by carefully encoding structural assumptions, from locality to sparsity to smoothness, into the optimization procedure. Surprisingly,…

Machine Learning · Computer Science 2026-04-10 Colin Doumont , Donney Fan , Natalie Maus , Jacob R. Gardner , Henry Moss , Geoff Pleiss