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Previous studies of chemotaxis models with consumption of the chemoattractant (with or without fluid) have not been successful in explaining pattern formation even in the simplest form of concentration near the boundary, which had been…

Analysis of PDEs · Mathematics 2019-02-05 Marcel Braukhoff , Johannes Lankeit

We consider a model of congestion dynamics with chemotaxis, where the density of cells follows the chemical signal it generates, while observing an incompressibility constraint. We show that when the chemical diffuses slowly and attracts…

Analysis of PDEs · Mathematics 2022-04-27 Inwon Kim , Antoine Mellet , Yijing Wu

A connection is established between discrete stochastic model describing microscopic motion of fluctuating cells, and macroscopic equations describing dynamics of cellular density. Cells move towards chemical gradient (process called…

Biological Physics · Physics 2010-05-18 Pavel M. Lushnikov , Nan Chen , Mark Alber

In this paper, a reaction-diffusion system modeling injection of a chemotherapeutic drug on the surface of a living tissue during a treatment for cancer patients is studied. The system describes the interaction of the chemotherapeutic drug…

Analysis of PDEs · Mathematics 2024-08-20 Jeff Morgan , Bao Quoc Tang , Hong-Ming Yin

This paper deals with the quasilinear fully parabolic attraction-repulsion chemotaxis system \begin{align*} u_t=\nabla \cdot (D(u)\nabla u) -\nabla \cdot (G(u)\chi(v)\nabla v) +\nabla\cdot(H(u)\xi(w)\nabla w), \quad v_t=d_1\Delta v+\alpha…

Analysis of PDEs · Mathematics 2021-08-10 Yutaro Chiyo , Tomomi Yokota

Many cellular and subcellular biological processes can be described in terms of diffusing and chemically reacting species (e.g. enzymes). Such reaction-diffusion processes can be mathematically modelled using either deterministic…

Biological Physics · Physics 2015-06-26 Radek Erban , S. Jonathan Chapman

Autologous chemotaxis, in which cells secrete and detect molecules to determine the direction of fluid flow, is thwarted at high cell density because molecules from other cells interfere with a given cell's signal. Using a minimal model of…

Biological Physics · Physics 2022-09-14 Michael Vennettilli , Louis Gonzalez , Nicholas Hilgert , Andrew Mugler

Directed cell motion in response to an external chemical gradient occurs in many biological phenomena such as wound healing, angiogenesis, and cancer metastasis. Chemotaxis is often characterized by the accuracy, persistence, and speed of…

Cell Behavior · Quantitative Biology 2019-06-19 Julien Varennes , Hye-ran Moon , Soutick Saha , Andrew Mugler , Bumsoo Han

Multicellular systems play a key role in bioprocess and biomedical engineering. Cell ensembles encountered in these setups show phenotypic variability like size and biochemical composition. As this variability may result in undesired…

Systems and Control · Computer Science 2018-07-16 Armin Küper , Robert Dürr , Steffen Waldherr

We discovered a class of self-similar solutions in nonlinear models describing the formation of morphogen gradients, the concentration fields of molecules acting as spatial regulators of cell differention in developing tissues. These models…

Quantitative Methods · Quantitative Biology 2015-05-28 Cyrill B. Muratov , Peter V. Gordon , Stanislav Y. Shvartsman

Chemical affinities are responsible for driving active matter systems out of equilibrium. At the nano-scale, molecular machines interact with the surrounding environment and are subjected to external forces. The mechano-chemical coupling…

Soft Condensed Matter · Physics 2025-01-03 Michalis Chatzittofi , Jaime Agudo-Canalejo , Ramin Golestanian

In this article, we study the existence of insensitizing controls for a nonlinear reaction-diffusion equation with dynamic boundary conditions. Here, we have a partially unknown data of the system, and the problem consists in finding…

Optimization and Control · Mathematics 2024-07-16 Mauricio C. Santos , Nicolás Carreño , Roberto Morales

Pattern formation often occurs in confined systems, yet how boundaries shape patterning dynamics is unclear. We develop techniques to analyze confinement effects in nonlocal advection-diffusion equations, which generically capture the…

Pattern Formation and Solitons · Physics 2025-09-11 Jan Rombouts , Michael L Zhao , Alexander Aulehla , Anna Erzberger

The effects of a boundary on reaction systems are examined in the framework of the general single-species reaction/coalescence process. The boundary naturally represents the reactants' container, but is applicable to exciton dynamics in a…

Statistical Mechanics · Physics 2009-10-31 M. J. E. Richardson , Y. Kafri

Nonlinear effects in emission and absorption spectra of gaseous systems are considered. It is shown that level splitting can be detected spectroscopically even if it is below the Doppler width. Conditions for distinguishing interference…

Quantum Physics · Physics 2007-05-23 T. Ya. Popova , A. K. Popov , S. G. Rautian , R. I. Sokolovskii

In the present review we focus on the chemotaxis-consumption model $\partial_t u - \Delta u = - \nabla \cdot (u \nabla v)$ and $\partial_t v - \Delta v = - u^s v$ in $(0,T) \times \Omega$, for any fixed $s \geq 1$, endowed with isolated…

Analysis of PDEs · Mathematics 2024-02-12 André Luiz Corrêa Vianna Filho , Francisco Guillén-González

We consider a model of congestion dynamics with chemotaxis: The density of cells follows a chemical signal it generates, while subject to an incompressibility constraint. The incompressibility constraint results in the formation of patches,…

Analysis of PDEs · Mathematics 2023-01-18 Inwon Kim , Antoine Mellet , Yijing Wu

This paper is concerned with the migration-consumption taxis system involving signal-dependent motilities $$\left\{ \begin{array}{l} u_t = \Delta \big(u^m\phi(v)\big), \\[1mm] v_t = \Delta v-uv, \end{array} \right. \qquad \qquad (\star)$$…

Analysis of PDEs · Mathematics 2023-04-26 Genglin Li , Liangchen Wang

When applied to binary solutions, thermal gradients lead to the generation of concentration-gradients and thus to inhomogeneous systems. While being known for more than 150 years, the molecular origins for this phenomenon are still debated,…

Soft Condensed Matter · Physics 2023-12-21 Mario Araujo-Rocha , Alejandro Diaz-Marquez , Guillaume Stirnemann

We study a biologically motivated model of overdamped, autochemotactic Brownian agents with concentration-dependent chemotactic sensitivity. The agents in our model move stochastically and produce a chemical ligand at their current…

Statistical Mechanics · Physics 2015-06-17 Marcel Meyer , Lutz Schimansky-Geier , Pawel Romanczuk