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We present a mathematical study for the development of Multiple Sclerosis in which a spatio-temporal kinetic { theory} model describes, at the mesoscopic level, the dynamics of a high number of interacting agents. We consider both…

Analysis of PDEs · Mathematics 2026-01-07 Romina Travaglini , João Miguel Oliveira

We investigate Turing instability and pattern formation in two-dimensional domains for two reaction-diffusion models, obtained as diffusive limits of kinetic equations for mixtures of monatomic and polyatomic gases. The first model is of…

Mathematical Physics · Physics 2026-02-23 Stefano Boccelli , Giorgio Martalò , Romina Travaglini

Multiple Sclerosis is a chronic autoimmune disorder characterized by the degradation of the myelin sheath in the central nervous system, leading to neurological impairments. In this work, we analyze a reaction-diffusion model derived from…

Tissues and Organs · Quantitative Biology 2026-03-10 Romina Travaglini , Rossella Della Marca

We consider a system of reaction-diffusion equations including chemotaxis terms and coming out of the modeling of multiple sclerosis. The global existence of strong solutions to this system in any dimension is proved, and it is also shown…

Analysis of PDEs · Mathematics 2020-09-29 Laurent Desvillettes , Valeria Giunta , Jeff Morgan , Bao Quoc Tang

We present a mathematical study for the development of multiple sclerosis based on a reaction-diffusion system. The model describes interactions among different populations of human cells, motion of immune cells stimulated by cytokines,…

Tissues and Organs · Quantitative Biology 2026-01-07 Romina Travaglini

We investigated existence of global weak solutions for a system of chemotaxis type with nonlinear degenerate diffusion, arising in modelling Multiple Sclerosis disease. The model consists of three equations describing the evolution of…

Analysis of PDEs · Mathematics 2024-05-10 S. Fagioli , E. Radici , L. Romagnoli

In this paper, we study a modification of the mathematical model describing inflammation and demyelination patterns in the brain caused by Multiple Sclerosis proposed in [Lombardo et al. (2017), Journal of Mathematical Biology, 75,…

Analysis of PDEs · Mathematics 2023-03-06 Marzia Bisi , Maria Groppi , Giorgio Martalò , Cinzia Soresina

This paper investigates pattern formation in reaction--diffusion systems with both diffusive and nondiffusive components, providing necessary and sufficient conditions for diffusion-driven instability (DDI) and establishing the existence of…

Analysis of PDEs · Mathematics 2026-05-07 Théo André , Szymon Cygan , Anna Marciniak-Czochra , Finn Münnich

General conditions are established under which reaction-cross-diffusion systems can undergo spatiotemporal pattern-forming instabilities. Recent work has focused on designing systems theoretically and experimentally to exhibit patterns with…

Pattern Formation and Solitons · Physics 2025-08-26 Edgardo Villar-Sepúlveda , Alan R. Champneys , Andrew L. Krause

The Turing instability paradigm is revisited in the context of a multispecies diffusion scheme derived from a self-consistent microscopic formulation. The analysis is developed with reference to the case of two species. These latter share…

Biological Physics · Physics 2012-07-02 Duccio Fanelli , Claudia Cianci , Francesca Di Patti

Turing instabilities of reaction-diffusion systems can only arise if the diffusivities of the chemical species are sufficiently different. This threshold is unphysical in most systems with $N=2$ diffusing species, forcing experimental…

Soft Condensed Matter · Physics 2026-03-17 Pierre A. Haas , Raymond E. Goldstein

The aim of this paper is to contribute to the understanding of the pattern formation phenomenon in reaction-diffusion equations coupled with ordinary differential equations. Such systems of equations arise, for example, from modeling of…

Analysis of PDEs · Mathematics 2016-07-15 Anna Marciniak-Czochra , Grzegorz Karch , Kanako Suzuki

Signaling molecules play an important role for many cellular functions. We investigate here a general system of two membrane reaction-diffusion equations coupled to a diffusion equation inside the cell by a Robin-type boundary condition and…

Analysis of PDEs · Mathematics 2015-06-16 Andreas Rätz , Matthias Röger

The modelling of linear and nonlinear reaction-subdiffusion processes is more subtle than normal diffusion and causes different phenomena. The resulting equations feature a spatial Laplacian with a temporal memory term through a time…

Analysis of PDEs · Mathematics 2021-08-24 Jichen Yang , Jens D. M. Rademacher

Symmetry-breaking instabilities play an important role in understanding the mechanisms underlying the diversity of patterns observed in nature, such as in Turing's reaction--diffusion theory, which connects cellular signalling and transport…

Pattern Formation and Solitons · Physics 2023-12-25 Andrew L. Krause , Eamonn A. Gaffney , Thomas Jun Jewell , Václav Klika , Benjamin J. Walker

This paper aims to investigate a reaction-diffusion model which describes in-host infection for Mycobacterium tuberculosis (Mtb) allowing random motion (i.e. linear diffusion) and chemotaxis (i.e. non-linear diffusion) of macrophages and…

Populations and Evolution · Quantitative Biology 2024-10-16 C. Accarino , R. Accarino , F. Capone , R. De Luca , L. Fiorentino , G. Massa

We consider a two dimensional Turing like system with two diffusing species which interact with each other. Considering the species to be charged, we include the effect of an electric field along a given direction which can lead to a drift…

Other Condensed Matter · Physics 2008-12-31 B K Agarwalla , J K Bhattacharjee , P Titum

The study of pattern-forming instabilities in reaction-diffusion systems on growing or otherwise time-dependent domains arises in a variety of settings, including applications in developmental biology, spatial ecology, and experimental…

Pattern Formation and Solitons · Physics 2022-07-11 Robert A. Van Gorder , Václav Klika , Andrew L. Krause

The study of pattern emergence together with exploration of the exemplar Turing model is enjoying a renaissance both from theoretical and experimental perspective. Here, we implement a stability analysis of spatially dependent reaction…

Pattern Formation and Solitons · Physics 2019-11-06 Michal Kozák , Eamonn A Gaffney , Václav Klika

An asymptotic method for finding instabilities of arbitrary $d$-dimensional large-amplitude patterns in a wide class of reaction-diffusion systems is presented. The complete stability analysis of 2- and 3-dimensional localized patterns is…

patt-sol · Physics 2009-10-30 C. B. Muratov , V. V. Osipov
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