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Continuous glucose monitoring (CGM) is a minimally invasive technology that measures blood glucose every few minutes for weeks or months at a time. CGM data are often collected in the free-living environment and is strongly related to…

Methodology · Statistics 2025-09-04 Marcos Matabuena , Ciprian M. Crainiceanu

Establishing optimal cut-offs for clinical biomarkers is a fundamental statistical problem in epidemiology, clinical trials, and drug discovery. While there is extensive literature regarding the definition of optimal cut-offs for scalar…

Methodology · Statistics 2025-03-11 Oscar Lado-Baleato , Carla Díaz-Louza , Francisco Gude , Marcos Matabuena

The classification of diabetes and prediabetes by static glucose thresholds obscures the pathophysiological dysglycemia heterogeneity, primarily driven by insulin resistance (IR), beta-cell dysfunction, and incretin deficiency. This review…

Machine Learning · Computer Science 2025-11-07 Ahmed A. Metwally , Heyjun Park , Yue Wu , Tracey McLaughlin , Michael P. Snyder

Biosensor data has the potential ability to improve disease control and detection. However, the analysis of these data under free-living conditions is not feasible with current statistical techniques. To address this challenge, we introduce…

Applications · Statistics 2021-03-30 Marcos Matabuena , Alexander Petersen , Juan C. Vidal , Francisco Gude

The rising rates of diabetes necessitate innovative methods for its management. Continuous glucose monitors (CGM) are small medical devices that measure blood glucose levels at regular intervals providing insights into daily patterns of…

Quantitative Methods · Quantitative Biology 2024-10-10 Renat Sergazinov , Elizabeth Chun , Valeriya Rogovchenko , Nathaniel Fernandes , Nicholas Kasman , Irina Gaynanova

In the U.S., over a third of adults are pre-diabetic, with 80\% unaware of their status. This underlines the need for better glucose monitoring to prevent type 2 diabetes and related heart diseases. Existing wearable glucose monitors are…

Signal Processing · Electrical Eng. & Systems 2024-06-26 Yidong Zhu , Nadia B Aimandi , Mohammad Arif Ul Alam

Continuous glucose monitoring (CGM) data has revolutionized the management of type 1 diabetes, particularly when integrated with insulin pumps to mitigate clinical events such as hypoglycemia. Recently, there has been growing interest in…

Continuous Blood Glucose (CGM) monitors have revolutionized the ability of diabetics to manage their blood glucose, and paved the way for artificial pancreas systems. In this paper we augment CGM data with sensor input collected by a smart…

Human-Computer Interaction · Computer Science 2023-02-06 Sam Royston

With the advent of continuous health monitoring with wearable devices, users now generate their unique streams of continuous data such as minute-level step counts or heartbeats. Summarizing these streams via scalar summaries often ignores…

The challenge of handling missing data is widespread in modern data analysis, particularly during the preprocessing phase and in various inferential modeling tasks. Although numerous algorithms exist for imputing missing data, the…

Methodology · Statistics 2024-03-28 Marcos Matabuena , Carla Díaz-Louzao , Rahul Ghosal , Francisco Gude

Wearable devices permit the continuous monitoring of biological processes, such as blood glucose metabolism, and behavior, such as sleep quality and physical activity. The continuous monitoring often occurs in epochs of 60 seconds over…

Methodology · Statistics 2024-04-23 Yuanyuan Luan , Roger S. Zoh , Erjia Cui , Xue Lan , Sneha Jadhav , Carmen D. Tekwe

Understanding how biomarker distributions evolve over time is a central challenge in digital health and chronic disease monitoring. In diabetes, changes in the distribution of glucose measurements can reveal patterns of disease progression…

Machine Learning · Statistics 2026-03-26 Antonio Álvarez-López , Marcos Matabuena

Sustained high levels of blood glucose in type 2 diabetes (T2DM) can have disastrous long-term health consequences. An essential component of clinical interventions for T2DM is monitoring dietary intake to keep plasma glucose levels within…

Quantitative Methods · Quantitative Biology 2022-06-24 Zepeng Huo , Bobak J. Mortazavi , Theodora Chaspari , Nicolaas Deutz , Laura Ruebush , Ricardo Gutierrez-Osuna

Diabetes Mellitus is a metabolic disorder which may result in severe and potentially fatal complications if not well-treated and monitored. In this study, a quantitative analysis of the data collected using CGM (Continuous Glucose…

Quantitative Methods · Quantitative Biology 2023-08-15 Giulia Elena Aliffi , Giovanni Nastasi , Vittorio Romano , Dario Pitocco , Alessandro Rizzi , Elvin J. Moore , Andrea De Gaetano

With the growing prevalence of diabetes and the associated public health burden, it is crucial to identify modifiable factors that could improve patients' glycemic control. In this work, we seek to examine associations between medication…

Applications · Statistics 2025-12-22 Alexander Coulter , Rashmi N. Aurora , Naresh M. Punjabi , Irina Gaynanova

With continuous glucose monitoring (CGM), data-driven models on blood glucose prediction have been shown to be effective in related work. However, such (CGM) systems are not always available, e.g., for a patient at home. In this work, we…

Computers and Society · Computer Science 2024-04-10 Tu Nguyen , Markus Rokicki

Suppose (standardized) measurements or statistics are monitored to raise an alarm when a threshold is exceeded. Often, the underlying population is heterogenous with respect to important discrete variables and thus samples may consist of…

Statistics Theory · Mathematics 2025-10-10 Ansgar Steland

The majority of Americans fail to achieve recommended levels of physical activity, which leads to numerous preventable health problems such as diabetes, hypertension, and heart diseases. This has generated substantial interest in monitoring…

Emerging wearable sensors have enabled the unprecedented ability to continuously monitor human activities for healthcare purposes. However, with so many ambient sensors collecting different measurements, it becomes important not only to…

Machine Learning · Computer Science 2019-01-09 Randy Ardywibowo , Guang Zhao , Zhangyang Wang , Bobak Mortazavi , Shuai Huang , Xiaoning Qian

Effective dietary monitoring is critical for managing Type 2 diabetes, yet accurately estimating caloric intake remains a major challenge. While continuous glucose monitors (CGMs) offer valuable physiological data, they often fall short in…

Computer Vision and Pattern Recognition · Computer Science 2025-05-21 Adarsh Kumar
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