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In this study, we present a novel clinical decision support system and discuss its interpretability-related properties. It combines a decision set of rules with a machine learning scheme to offer global and local interpretability. More…

Methodology · Statistics 2021-07-16 Francisco Valente , Simão Paredes , Jorge Henriques

Machine learning models that first learn a representation of a domain in terms of human-understandable concepts, then use it to make predictions, have been proposed to facilitate interpretation and interaction with models trained on…

Machine Learning · Computer Science 2020-12-08 Isaac Lage , Finale Doshi-Velez

While the uptake of data-driven approaches for materials science and chemistry is at an exciting, early stage, to realise the true potential of machine learning models for successful scientific discovery, they must have qualities beyond…

Materials Science · Physics 2022-06-28 Felipe Oviedo , Juan Lavista Ferres , Tonio Buonassisi , Keith Butler

The increasing use of complex machine learning models in education has led to concerns about their interpretability, which in turn has spurred interest in developing explainability techniques that are both faithful to the model's inner…

Machine Learning · Computer Science 2025-05-13 Juan D. Pinto , Luc Paquette

Interpretable machine learning has exploded as an area of interest over the last decade, sparked by the rise of increasingly large datasets and deep neural networks. Simultaneously, large language models (LLMs) have demonstrated remarkable…

Computation and Language · Computer Science 2024-02-06 Chandan Singh , Jeevana Priya Inala , Michel Galley , Rich Caruana , Jianfeng Gao

The lack of interpretability has hindered the large-scale adoption of AI technologies. However, the fundamental idea of interpretability, as well as how to put it into practice, remains unclear. We provide notions of interpretability based…

Machine Learning · Computer Science 2021-11-18 Hangcheng Dong , Bingguo Liu , Fengdong Chen , Dong Ye , Guodong Liu

Interpretability of deep neural networks (DNNs) is essential since it enables users to understand the overall strengths and weaknesses of the models, conveys an understanding of how the models will behave in the future, and how to diagnose…

Computer Vision and Pattern Recognition · Computer Science 2017-03-31 Yinpeng Dong , Hang Su , Jun Zhu , Bo Zhang

Though neural networks trained on large datasets have been successfully used to describe and predict many physical phenomena, there is a sense among scientists that, unlike traditional scientific models comprising simple mathematical…

Machine Learning · Computer Science 2026-04-23 Conor Rowan , Alireza Doostan

When quantitative models are used to support decision-making on complex and important topics, understanding a model's ``reasoning'' can increase trust in its predictions, expose hidden biases, or reduce vulnerability to adversarial attacks.…

Machine Learning · Computer Science 2019-07-09 Dimitris Bertsimas , Arthur Delarue , Patrick Jaillet , Sebastien Martin

Neural networks organize information according to the hierarchical, multi-scale structure of natural data. Methods to interpret model internals should be similarly scale-aware, explicitly tracking how features compose across resolutions and…

Deep learning has driven significant advances in medical image analysis, yet its adoption in clinical practice remains constrained by the large size and lack of transparency in modern models. Advances in interpretability techniques such as…

Computer Vision and Pattern Recognition · Computer Science 2025-09-23 Nikita Malik , Pratinav Seth , Neeraj Kumar Singh , Chintan Chitroda , Vinay Kumar Sankarapu

Supervised machine learning models boast remarkable predictive capabilities. But can you trust your model? Will it work in deployment? What else can it tell you about the world? We want models to be not only good, but interpretable. And yet…

Machine Learning · Computer Science 2017-03-07 Zachary C. Lipton

Machine learning methods can be a valuable aid in the scientific process, but they need to face challenging settings where data come from inhomogeneous experimental conditions. Recent meta-learning methods have made significant progress in…

Machine Learning · Computer Science 2024-03-21 Matthieu Blanke , Marc Lelarge

Society's capacity for algorithmic problem-solving has never been greater. Artificial Intelligence is now applied across more domains than ever, a consequence of powerful abstractions, abundant data, and accessible software. As capabilities…

Machine Learning · Statistics 2024-08-20 Kris Sankaran

The lack of interpretability and transparency are preventing economists from using advanced tools like neural networks in their empirical research. In this paper, we propose a class of interpretable neural network models that can achieve…

Econometrics · Economics 2020-12-01 Yucheng Yang , Zhong Zheng , Weinan E

In this review, we examine the problem of designing interpretable and explainable machine learning models. Interpretability and explainability lie at the core of many machine learning and statistical applications in medicine, economics,…

Machine Learning · Computer Science 2023-03-02 Ričards Marcinkevičs , Julia E. Vogt

Mechanistic interpretability focuses on reverse engineering the internal mechanisms learned by neural networks. We extend our focus and propose to mechanistically forward engineer using our framework based on Concept Bottleneck Models. In…

Machine Learning · Computer Science 2025-12-01 Angela van Sprang , Erman Acar , Willem Zuidema

We provide a novel notion of what it means to be interpretable, looking past the usual association with human understanding. Our key insight is that interpretability is not an absolute concept and so we define it relative to a target model,…

Artificial Intelligence · Computer Science 2017-07-14 Amit Dhurandhar , Vijay Iyengar , Ronny Luss , Karthikeyan Shanmugam

Deep learning (DL) models have been popular due to their ability to learn directly from the raw data in an end-to-end paradigm, alleviating the concern of a separate error-prone feature extraction phase. Recent DL-based neuroimaging studies…

Machine Learning · Computer Science 2023-07-20 Md. Mahfuzur Rahman , Vince D. Calhoun , Sergey M. Plis

Explainable AI aims to render model behavior understandable by humans, which can be seen as an intermediate step in extracting causal relations from correlative patterns. Due to the high risk of possible fatal decisions in image-based…

Computer Vision and Pattern Recognition · Computer Science 2023-06-16 Lukas Klein , João B. S. Carvalho , Mennatallah El-Assady , Paolo Penna , Joachim M. Buhmann , Paul F. Jaeger
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