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Quadriwave lateral shearing interferometry (QLSI) is a quantitative phase imaging technique based on the use of a diffraction grating placed in front of a camera. This grating creates a wire-mesh-like image, called an interferogram, that is…

Optics · Physics 2022-03-15 Guillaume Baffou

Imaging mass spectrometry (IMS) is a powerful tool for untargeted, highly multiplexed molecular mapping of tissue in biomedical research. IMS offers a means of mapping the spatial distributions of molecular species in biological tissue with…

Computer Vision and Pattern Recognition · Computer Science 2025-08-05 Yijie Zhang , Luzhe Huang , Nir Pillar , Yuzhu Li , Lukasz G. Migas , Raf Van de Plas , Jeffrey M. Spraggins , Aydogan Ozcan

Purpose: Quantitative phase imaging (QPI) is a label-free technique that provides high-contrast images of tissues and cells without the use of chemicals or dyes. Accurate semantic segmentation of cells in QPI is essential for various…

Image and Video Processing · Electrical Eng. & Systems 2024-05-13 Zhuchen Shao , Mark A. Anastasio , Hua Li

Resolving how defects emerge and interact within the hierarchical structure of polycrystalline materials remains a core challenge in materials science. Grain-mapping methods such as three-dimensional X-ray diffraction (3DXRD) and…

Semi-transparent mirrors are standard elements in light optics for splitting light beams or creating two versions of the same image. Such mirrors do not exist in electron optics, although they could be beneficial in existing techniques such…

Quantum Physics · Physics 2018-10-24 Yujia Yang , Chung-Soo Kim , Richard G. Hobbs , Pieter Kruit , Karl K. Berggren

Quantitative phase imaging (QPI) enables visualization and quantitative extraction of the optical phase information of transparent samples. However, conventional QPI techniques typically rely on multi-frame acquisition or complex…

Usually, off-axis digital holographic microscopy requires a coherent light source in order to record a full-field hologram. Nevertheless, a LASER-based illumination leads to a non-negligible coherent noise, decreasing then the imaging…

Optics · Physics 2021-11-02 Stephane Perrin , Jonas Kuhn , Christian Depeursinge

Modulation-enhanced localization microscopy (MELM) has demonstrated significant improvements in both lateral and axial localization precision compared to conventional single-molecule localization microscopy (SMLM). However, lateral…

Quantitative phase imaging (QPI) quantifies the sample-specific optical-phase-delay enabling objective studies of optically-transparent specimens such as biological samples, but lacks chemical sensitivity limiting its application to…

Optics · Physics 2019-09-04 Miu Tamamitsu , Keiichiro Toda , Ryoichi Horisaki , Takuro Ideguchi

Despite recent advances, high performance single-shot 3D microscopy remains an elusive task. By introducing designed diffractive optical elements (DOEs), one is capable of converting a microscope into a 3D "kaleidoscope", in which case the…

Ptychography has become prominent at synchrotron facilities worldwide for characterizing biological and material specimens' topological structures and properties at the nanometer or atomic scale, due to its lens - less, highly quantitative…

Image and Video Processing · Electrical Eng. & Systems 2025-01-28 Tao Liu , Bingyang Wang , JiangTao Zhao , Maik Kahnt , Fucai Zhang

Diffuse optical imaging (DOI) offers valuable insights into scattering mediums, but the quest for high-resolution imaging often requires dense sampling strategies, leading to higher imaging errors and lengthy acquisition times. This work…

Optics · Physics 2025-04-07 Ben Wiesel , Shlomi Arnon

In the present work we discuss a possibility to build an instrument with two operation modes - spectral and imaging ones. The key element of such instrument is a dispersive and filtering unit consisting of two narrowband volume-phase…

Instrumentation and Methods for Astrophysics · Physics 2017-05-16 Eduard R. Muslimov , Sergei N. Fabrika , Gennady G. Valyavin

Snapshot multi-dimensional imaging offers a promising alternative to traditional low-dimensional imaging techniques by enabling the simultaneous capture of spatial, spectral, polarization, and other information in a single shot for improved…

We demonstrate a motion-free intensity diffraction tomography technique that enables direct inversion of 3D phase and absorption from intensity-only measurements for weakly scattering samples. We derive a novel linear forward model,…

Image and Video Processing · Electrical Eng. & Systems 2018-06-26 Ruilong Ling , Waleed Tahir , Hsing-Ying Lin , Hakho Lee , Lei Tian

Lensless imaging is a popular research field for the advantages of small size, wide field-of-view and low aberration in recent years. However, some traditional lensless imaging methods suffer from slow convergence, mechanical errors and…

End-to-end optimization of diffractive optical elements (DOEs) profile through a digital differentiable model combined with computational imaging have gained an increasing attention in emerging applications due to the compactness of…

In the context of emerging stacked intelligent metasurface (SIM)-based holographic MIMO (HMIMO) systems, a fundamental problem is to study the mutual information (MI) between transmitted and received signals to establish their capacity.…

Information Theory · Computer Science 2024-08-27 Nemanja Stefan Perović , Le-Nam Tran

We present a powerful and cost-effective method for active illumination using a digital micromirror device (DMD) for quantitative phase imaging techniques. Displaying binary illumination patterns on a DMD with appropriate spatial filtering,…

Optics · Physics 2023-07-19 Seungwoo Shin , Kyoohyun Kim , Jonghee Yoon , YongKeun Park

Nonlinear structured illumination microscopy (nSIM) is an effective approach for super-resolution wide-field fluorescence microscopy with a theoretically unlimited resolution. In nSIM, carefully designed, highly-contrasted illumination…