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Large language models (LLMs) in biomedicine face a fundamental conflict between static parameter knowledge and the dynamic nature of clinical evidence. Retrieval-Augmented Generation (RAG) addresses this by grounding generation in external…

Other Quantitative Biology · Quantitative Biology 2025-12-19 Jiawei He , Boya Zhang , Hossein Rouhizadeh , Yingjian Chen , Rui Yang , Jin Lu , Xudong Chen , Nan Liu , Douglas Teodoro

Large language models (LLMs) have achieved strong empirical performance in various fields, benefiting from their huge amount of parameters that store knowledge. However, LLMs still suffer from several key issues, such as hallucination…

Computation and Language · Computer Science 2026-05-20 Shangyu Wu , Ying Xiong , Yufei Cui , Haolun Wu , Can Chen , Ye Yuan , Lianming Huang , Xue Liu , Tei-Wei Kuo , Nan Guan , Chun Jason Xue

Large Language Models (LLMs) showcase remarkable abilities, yet they struggle with limitations such as hallucinations, outdated knowledge, opacity, and inexplicable reasoning. To address these challenges, Retrieval-Augmented Generation…

Computation and Language · Computer Science 2024-10-03 Sourav Verma

Retrieval-augmented Generation (RAG) has markedly enhanced the capabilities of Large Language Models (LLMs) in tackling knowledge-intensive tasks. The increasing demands of application scenarios have driven the evolution of RAG, leading to…

Computation and Language · Computer Science 2024-08-01 Yunfan Gao , Yun Xiong , Meng Wang , Haofen Wang

The evolution of Large Language Models (LLMs) from passive text generators to autonomous, goal-driven systems represents a fundamental shift in artificial intelligence. This chapter examines the emergence of agentic AI systems that…

Artificial Intelligence · Computer Science 2026-01-07 Nadia Sibai , Yara Ahmed , Serry Sibaee , Sawsan AlHalawani , Adel Ammar , Wadii Boulila

Conventional Retrieval-Augmented Generation (RAG) systems enhance Large Language Models (LLMs) but often fall short on complex queries, delivering limited, extractive answers and struggling with multiple targeted retrievals or navigating…

Artificial Intelligence · Computer Science 2026-03-27 Jean Lelong , Adnane Errazine , Annabelle Blangero

Incident response (IR) requires fast, coordinated, and well-informed decision-making to contain and mitigate cyber threats. While large language models (LLMs) have shown promise as autonomous agents in simulated IR settings, their reasoning…

Computation and Language · Computer Science 2025-10-07 Zefang Liu , Arman Anwar

Retrieval-Augmented Generation (RAG) has significantly enhanced LLMs by incorporating external information. However, prevailing agentic RAG approaches are constrained by a critical limitation: they treat the retrieval process as a black-box…

Information Retrieval · Computer Science 2026-02-27 Yulong Hui , Chao Chen , Zhihang Fu , Yihao Liu , Jieping Ye , Huanchen Zhang

Large Language Models (LLMs) are smart but forgetful. Recent studies, (e.g., (Bubeck et al., 2023)) on modern LLMs have shown that they are capable of performing amazing tasks typically necessitating human-level intelligence. However,…

Computation and Language · Computer Science 2023-11-08 Eric Melz

Retrieval-Augmented Generation (RAG) mitigates key limitations of Large Language Models (LLMs)-such as factual errors, outdated knowledge, and hallucinations-by dynamically retrieving external information. Recent work extends this paradigm…

Computation and Language · Computer Science 2026-05-22 Jingru Lin , Chen Zhang , Stephen Y. Liu , Haizhou Li

Effective knowledge management is critical for preserving institutional expertise and improving the efficiency of workforce training in state transportation agencies. Traditional approaches, such as static documentation, classroom-based…

Computation and Language · Computer Science 2026-03-05 Divija Amaram , Lu Gao , Gowtham Reddy Gudla , Tejaswini Sanjay Katale

Personalization has become an essential capability in modern AI systems, enabling customized interactions that align with individual user preferences, contexts, and goals. Recent research has increasingly concentrated on Retrieval-Augmented…

Retrieval Augmented Generation (RAG) systems have seen huge popularity in augmenting Large-Language Model (LLM) outputs with domain specific and time sensitive data. Very recently a shift is happening from simple RAG setups that query a…

Information Retrieval · Computer Science 2024-03-05 Tristan Kenneweg , Philip Kenneweg , Barbara Hammer

Frontier language models have demonstrated strong reasoning and long-horizon tool-use capabilities. However, existing RAG systems fail to leverage these capabilities. They still rely on two paradigms: (1) designing an algorithm that…

Computation and Language · Computer Science 2026-02-04 Mingxuan Du , Benfeng Xu , Chiwei Zhu , Shaohan Wang , Pengyu Wang , Xiaorui Wang , Zhendong Mao

The rapid growth of medical knowledge and increasing complexity of clinical practice pose challenges. In this context, large language models (LLMs) have demonstrated value; however, inherent limitations remain. Retrieval-augmented…

Retrieval Augmented Generation (RAG) is a technique used to augment Large Language Models (LLMs) with contextually relevant, time-critical, or domain-specific information without altering the underlying model parameters. However,…

Information Retrieval · Computer Science 2024-08-20 Laurent Mombaerts , Terry Ding , Adi Banerjee , Florian Felice , Jonathan Taws , Tarik Borogovac

Retrieval-Augmented Generation (RAG) systems often face limitations in specialized domains such as fintech, where domain-specific ontologies, dense terminology, and acronyms complicate effective retrieval and synthesis. This paper…

Artificial Intelligence · Computer Science 2025-10-30 Thomas Cook , Richard Osuagwu , Liman Tsatiashvili , Vrynsia Vrynsia , Koustav Ghosal , Maraim Masoud , Riccardo Mattivi

Reinforcement Learning (RL) has traditionally focused on training specialized agents to optimize predefined reward functions within narrowly defined environments. However, the advent of powerful Large Language Models (LLMs) and increasingly…

Artificial Intelligence · Computer Science 2026-05-18 Fangming Cui , Ruixiao Zhu , Cheng Fang , Sunan Li , Jiahong Li

The emergence of Large Language Models (LLMs) has significantly advanced natural language processing, but these models often generate factually incorrect information, known as "hallucination". Initial retrieval-augmented generation (RAG)…

Computation and Language · Computer Science 2024-11-12 Yujia Zhou , Zheng Liu , Zhicheng Dou

Recent advances in Large Language Model (LLM)-based agents have been propelled by Retrieval-Augmented Generation (RAG), which grants the models access to vast external knowledge bases. Despite RAG's success in improving agent performance,…

Computation and Language · Computer Science 2025-11-06 Shuhang Lin , Zhencan Peng , Lingyao Li , Xiao Lin , Xi Zhu , Yongfeng Zhang