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Animal brains exhibit remarkable efficiency in perception and action, while being robust to both external and internal perturbations. The means by which brains accomplish this remains, for now, poorly understood, hindering our understanding…

Neurons and Cognition · Quantitative Biology 2026-03-11 André Urbano , Pablo Lanillos , Sander Keemink

Over the past two decades, an increasing array of control-theoretic methods have been used to study the brain as a complex dynamical system and better understand its structure-function relationship. This article provides an overview on one…

Neurons and Cognition · Quantitative Biology 2024-10-18 Michael McCreesh , Erfan Nozari , Jorge Cortes

Network control theory has recently emerged as a promising approach for understanding brain function and dynamics. By operationalizing notions of control theory for brain networks, it offers a fundamental explanation for how brain dynamics…

Quantitative Methods · Quantitative Biology 2020-03-20 Shikuang Deng , Shi Gu

Experiments suggest that cerebral cortex gains several functional advantages by operating in a dynamical regime near the critical point of a phase transition. However, a long-standing criticism of this hypothesis is that critical dynamics…

Neurons and Cognition · Quantitative Biology 2020-09-30 Kathleen Finlinson , Woodrow L. Shew , Daniel B. Larremore , Juan G. Restrepo

Most existing neural network-based approaches for solving stochastic optimal control problems using the associated backward dynamic programming principle rely on the ability to simulate the underlying state variables. However, in some…

Machine Learning · Statistics 2024-01-30 Christian Yeo

This paper introduces a new formulation for stochastic optimal control and stochastic dynamic optimization that ensures safety with respect to state and control constraints. The proposed methodology brings together concepts such as…

Systems and Control · Electrical Eng. & Systems 2021-02-19 Marcus Aloysius Pereira , Ziyi Wang , Ioannis Exarchos , Evangelos A. Theodorou

Neurons communicate with downstream systems via sparse and incredibly brief electrical pulses, or spikes. Using these events, they control various targets such as neuromuscular units, neurosecretory systems, and other neurons in connected…

Neurons and Cognition · Quantitative Biology 2026-03-17 Paolo Agliati , André Urbano , Pablo Lanillos , Nasir Ahmad , Marcel van Gerven , Sander Keemink

Efficient and robust control using spiking neural networks (SNNs) is still an open problem. Whilst behaviour of biological agents is produced through sparse and irregular spiking patterns, which provide both robust and efficient control,…

Neural and Evolutionary Computing · Computer Science 2023-07-18 Filip S. Slijkhuis , Sander W. Keemink , Pablo Lanillos

Attempts from different disciplines to provide a fundamental understanding of deep learning have advanced rapidly in recent years, yet a unified framework remains relatively limited. In this article, we provide one possible way to align…

Machine Learning · Computer Science 2019-10-01 Guan-Horng Liu , Evangelos A. Theodorou

Efficiently computing the optimal control policy concerning a complicated future with stochastic disturbance has always been a challenge. The predicted stochastic future disturbance can be represented by a scenario tree, but solving the…

Systems and Control · Electrical Eng. & Systems 2021-08-31 Ran Jing , Xiangrui Zeng

Optimal control models have been successful in describing many aspects of human movement. The interpretation of such models regarding neuronal implementation of the human motor system is not clear. An important aspects of optimal control…

Systems and Control · Computer Science 2016-01-08 Geoffrey George Gamble , Mehrdad Yazdani

Network control theory can be used to model how one should steer the brain between different states by driving a specific region with an input. The needed energy to control a network is often used to quantify its controllability, and…

Computational Engineering, Finance, and Science · Computer Science 2023-08-03 Seyed Samie Alizadeh Darbandi , Alex Fornito , Abdorasoul Ghasemi

We propose a novel unsupervised learning framework for solving nonlinear optimal control problems (OCPs) with input constraints in real-time. In this framework, a neural network (NN) learns to predict the optimal co-state trajectory that…

Systems and Control · Electrical Eng. & Systems 2025-07-17 Lihan Lian , Yuxin Tong , Uduak Inyang-Udoh

Modeling brain dynamics to better understand and control complex behaviors underlying various cognitive brain functions are of interests to engineers, mathematicians, and physicists from the last several decades. With a motivation of…

Neurons and Cognition · Quantitative Biology 2019-08-21 Benjamin Plaster , Gautam Kumar

Recent experimental and theoretical studies have indicated that the putative criticality of cortical dynamics may corresponds to a synchronization phase transition. The critical dynamics near such a critical point needs further…

Disordered Systems and Neural Networks · Physics 2022-05-04 Mahsa Khoshkhou , Afshin Montakhab

A central problem in systems neuroscience is to determine how an external stimulation is propagated through the brain so as to produce a reaction. Current deterministic and stochastic control models quantify transition costs between brain…

Optimization and Control · Mathematics 2026-03-23 Cristian Mendico

Recent advances at the intersection of control theory, neuroscience, and machine learning have revealed novel mechanisms by which dynamical systems perform computation. These advances encompass a wide range of conceptual, mathematical, and…

Machine Learning · Computer Science 2026-04-10 Arthur N. Montanari , Francesco Bullo , Dmitry Krotov , Adilson E. Motter

Trajectory optimization is a fundamental stochastic optimal control problem. This paper deals with a trajectory optimization approach for dynamical systems subject to measurement noise that can be fitted into linear time-varying stochastic…

Systems and Control · Electrical Eng. & Systems 2021-08-24 Prakash Mallick , Zhiyong Chen

Stochastic gradient descent requires that training samples be drawn from a uniformly random distribution of the data. For a deployed system that must learn online from an uncontrolled and unknown environment, the ordering of input samples…

Neural and Evolutionary Computing · Computer Science 2020-01-29 Jason M. Allred , Kaushik Roy

In this article, we study optimal control problems of spiking neurons whose dynamics are described by a phase model. We design minimum-power current stimuli (controls) that lead to targeted spiking times of neurons, where the cases with…

Dynamical Systems · Mathematics 2010-11-18 Isuru Dasanayake , Jr-Shin Li