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Large language models (LLMs) are already being piloted for clinical use in hospital systems like NYU Langone, Dana-Farber and the NHS. A proposed deployment use case is psychotherapy, where a LLM-powered chatbot can treat a patient…

Computation and Language · Computer Science 2024-10-10 Saadia Gabriel , Isha Puri , Xuhai Xu , Matteo Malgaroli , Marzyeh Ghassemi

Textual data from social platforms captures various aspects of mental health through discussions around and across issues, while users reach out for help and others sympathize and offer support. We propose a comprehensive framework that…

Social and Information Networks · Computer Science 2025-03-04 Vaishali Aggarwal , Sachin Thukral , Krushil Patel , Arnab Chatterjee

Although large language models (LLMs) have been assessed for general medical knowledge using licensing exams, their ability to support clinical decision-making, such as selecting medical calculators, remains uncertain. We assessed nine…

Computation and Language · Computer Science 2025-03-25 Nicholas Wan , Qiao Jin , Joey Chan , Guangzhi Xiong , Serina Applebaum , Aidan Gilson , Reid McMurry , R. Andrew Taylor , Aidong Zhang , Qingyu Chen , Zhiyong Lu

Large language models (LLMs) have achieved remarkable advancements in natural language processing. However, the massive scale and computational demands of these models present formidable challenges when considering their practical…

Computation and Language · Computer Science 2024-04-09 Weize Liu , Guocong Li , Kai Zhang , Bang Du , Qiyuan Chen , Xuming Hu , Hongxia Xu , Jintai Chen , Jian Wu

Mental health forums offer valuable insights into psychological issues, stressors, and potential solutions. We propose MHINDR, a large language model (LLM) based framework integrated with DSM-5 criteria to analyze user-generated text,…

Social and Information Networks · Computer Science 2025-10-01 Vaishali Agarwal , Sachin Thukral , Arnab Chatterjee

Logical reasoning consistently plays a fundamental and significant role in the domains of knowledge engineering and artificial intelligence. Recently, Large Language Models (LLMs) have emerged as a noteworthy innovation in natural language…

Computation and Language · Computer Science 2024-09-17 Fangzhi Xu , Qika Lin , Jiawei Han , Tianzhe Zhao , Jun Liu , Erik Cambria

Large language models (LLMs) show promise for improving the efficiency of qualitative analysis in large, multi-site health-services research. Yet methodological guidance for LLM integration into qualitative analysis and evidence of their…

Computation and Language · Computer Science 2026-01-22 Sasha Ronaghi , Emma-Louise Aveling , Maria Levis , Rachel Lauren Ross , Emily Alsentzer , Sara Singer

Large language models (LLMs) have shown considerable potential in supporting medical diagnosis. However, their effective integration into clinical workflows is hindered by physicians' difficulties in perceiving and trusting LLM…

Human-Computer Interaction · Computer Science 2026-01-28 Yuansong Xu , Yichao Zhu , Haokai Wang , Yuchen Wu , Yang Ouyang , Hanlu Li , Wenzhe Zhou , Xinyu Liu , Chang Jiang , Quan Li

In psychological practices, standardized questionnaires serve as essential tools for assessing mental health through structured, clinically-validated questions (i.e., items). While social media platforms offer rich data for mental health…

Computation and Language · Computer Science 2025-06-03 Federico Ravenda , Seyed Ali Bahrainian , Andrea Raballo , Antonietta Mira , Noriko Kando

This paper explores the use of large language models (LLMs) as research tools in the history, philosophy, and sociology of science (HPSS). LLMs are remarkably effective at processing unstructured text and inferring meaning from context,…

Computation and Language · Computer Science 2025-06-17 Arno Simons , Michael Zichert , Adrian Wüthrich

Cognitive systems generally require a human to translate a problem definition into some specification that the cognitive system can use to attempt to solve the problem or perform the task. In this paper, we illustrate that large language…

Artificial Intelligence · Computer Science 2024-06-12 Robert E. Wray , James R. Kirk , John E. Laird

There is a significant gap between patient needs and available mental health support today. In this paper, we aim to thoroughly examine the potential of using Large Language Models (LLMs) to assist professional psychotherapy. To this end,…

Computation and Language · Computer Science 2025-01-28 Mian Zhang , Xianjun Yang , Xinlu Zhang , Travis Labrum , Jamie C. Chiu , Shaun M. Eack , Fei Fang , William Yang Wang , Zhiyu Zoey Chen

Current clinical decision support systems (CDSSs) typically base their predictions on correlation, not causation. In recent years, causal machine learning (ML) has emerged as a promising way to improve decision-making with CDSSs by offering…

Human-Computer Interaction · Computer Science 2026-04-17 Domenique Zipperling , Lukas Schmidt , Benedikt Hahn , Niklas Kühl , Steven Kimbrough

The trade-off between expressiveness and interpretability remains a core challenge when building human-centric predictive models for classification and decision-making. While symbolic rules offer interpretability, they often lack…

Artificial Intelligence · Computer Science 2024-06-26 Ruochen Wang , Si Si , Felix Yu , Dorothea Wiesmann , Cho-Jui Hsieh , Inderjit Dhillon

General-purpose Large Language Models (LLMs) are becoming widely adopted by people for mental health support. Yet emerging evidence suggests there are significant risks associated with high-frequency use, particularly for individuals…

Computation and Language · Computer Science 2026-04-06 May Lynn Reese , Markela Zeneli , Mindy Ng , Jacob Haimes , Andreea Damien , Elizabeth Stade

A Large Language Model (LLM) represents a cutting-edge artificial intelligence model that generates coherent content, including grammatically precise sentences, human-like paragraphs, and syntactically accurate code snippets. LLMs can play…

Software Engineering · Computer Science 2023-12-11 Robson Santos , Italo Santos , Cleyton Magalhaes , Ronnie de Souza Santos

The potential of large language models (LLMs) as decision support tools is increasingly being explored in fields such as business, engineering, and medicine, which often face challenging tasks of decision-making under uncertainty. In this…

Artificial Intelligence · Computer Science 2024-10-14 Ollie Liu , Deqing Fu , Dani Yogatama , Willie Neiswanger

The integration of Large Language Models (LLMs) into the drug discovery and development field marks a significant paradigm shift, offering novel methodologies for understanding disease mechanisms, facilitating drug discovery, and optimizing…

Quantitative Methods · Quantitative Biology 2024-09-10 Yizhen Zheng , Huan Yee Koh , Maddie Yang , Li Li , Lauren T. May , Geoffrey I. Webb , Shirui Pan , George Church

This paper investigates the utilization of Large Language Models (LLMs) for solving complex linguistic puzzles, a domain requiring advanced reasoning and adept translation capabilities akin to human cognitive processes. We explore specific…

Computation and Language · Computer Science 2025-02-04 Zheng-Lin Lin , Yu-Fei Shih , Shu-Kai Hsieh

Recovering the structure of causal graphical models from observational data is an essential yet challenging task for causal discovery in scientific scenarios. Domain-specific causal discovery usually relies on expert validation or prior…

Artificial Intelligence · Computer Science 2025-08-27 Taiyu Ban , Lyuzhou Chen , Derui Lyu , Xiangyu Wang , Qinrui Zhu , Qiang Tu , Huanhuan Chen
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